ISSN:
1435-1803
Keywords:
Myocardial ischemia
;
coronary reperfusion
;
left atrial function
;
left ventricular function
;
digital subtraction angiography
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The left atrial (LA) function during coronary artery occlusion followed by reperfusion using densitometric analysis of digital atrioventriculographic images was evaluated. Eight anesthetized dogs underwent atrioventriculography at baseline, 10 and 60 min after left circumflex coronary artery (LCX) occlusion and 5, 30, 60, and 120 min of reperfusion. Time-density curves were obtained for LA and left ventricle (LV). The ratios of passive atrial video-densitometric change (VC) to total VC (Passive Ratio), and active VC to total VC (Active Ratio) were calculated. Left ventricular ejection fraction (LVEF), peak ejection rate (PER), and peak filling rate (PFR) were derived. Active Ratio, an index of atrial contraction, increased to 144%, and Passive Ratio decreased to 75% of baseline at 60 min of LCX occlusion. Two hours after reperfusion, both Active and Passive Ratios returned to control level. While LVEF reduced to 70%, PER to 67%, LV peak positive dP/dt to 88% of baseline at 60 min after occlusion, and remained depressed at 2h after reperfusion. However, PFR, LV peak negative dP/dt and LV isovolumic pressure decay rate showed recovery at 2h after reperfusion. There were significant correlations between PFR and Passive Ratio (r=0.41), and between Active and Passive Ratios (r=0.55). Thus, time-course of recovery of LV post-ischemic systolic and diastolic function was different. Return of LA function to control level during 2h after reperfusion may be depend on recovery of LV diastolic function.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00794998
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