ISSN:
1432-072X
Keywords:
Siderophore
;
Iron-uptake
;
Acinetobacter baumannii
;
Acinetobactin
;
ω-N-Hydroxyhistamine 2,3-Dihydroxybenzoic acid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract A novel siderophore, called acinetobactin, with both catecholate and hydroxamate functional groups was isolated from low-iron cultures of Acinetobacter baumannii ATCC 19606. The structure was elucidated by chemical degradation, fast-atom bombardment mass spectrometry and 1H and 13C NMR spectroscopy. Acinetobactin was composed of ω-N-hydroxyhistamine, threonine and 2,3-dihydroxybenzoic acid, the last two components forming an oxazoline ring. Acinetobactin was structurally related to anguibactin, a plasmid-encoded siderophore of Vibrio anguillarum. The only difference was that acinetobactin possessed an oxazoline ring instead of a thiazoline ring. Four of 12 other clinical A. baumannii strains examined produced acinetobactin, indicative of strain-to-strain variation in the ability to produce acinetobactin. In addition, a relatively small amount of acinetobactin was also detected in A. haemolyticus ATCC 17906.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00301846
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