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  • 1
    Electronic Resource
    Electronic Resource
    Microphase separation in thin films of the symmetric diblock-copolymer melt (1994)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 101 (1994), S. 3367-3377 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: By means of Monte Carlo simulations of a lattice model, microphase separation transition of symmetric diblock-copolymer melts confined in the thin-film geometry between parallel hard walls is studied. We impose a surface field which acts repulsively only on one of the two species, to stabilize lamellar order parallel to the surfaces. However, interplay between two characteristic lengths, that is, the natural thickness of the lamellar l and the thickness of the film D, causes complicated behavior. In case that the two lengths are compatible with each other, clear lamellar order parallel to the surfaces is observed at temperatures lower than the bulk transition temperature, as expected. On the other hand, tilted or deformed lamellar structure, or even coexistence of lamellae in different orientations are found in cases of strong conflict. In both cases, lamellae are fully established. Even at temperature higher than the bulk transition temperature, weak order is induced by the surface field, and a gradual transition between such surface-induced order and bulklike order is observed. Film thickness and temperature dependence of the ordered structure is discussed, as well as a density reduction near the walls and in the interfaces between the segregated regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.467584
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  • 2
    Electronic Resource
    Electronic Resource
    Heterogeneity of Epstein-Barr virus infection in angioimmunoblastic lymphadenopathy type T-cell lymphoma (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 25 (1994), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To investigate the relationship of Epstein-Barr virus (EBV) and angioimmunoblastic lymphadenopathy with dysproteinemia, we performed DNA analysis using the polymerase chain reaction (PCR), Southern blot, in situ hybridization, and immunohistochemical analysis of lymph nodes in five patients who were followed up and biopsied more than once. In the course of the disease, nodal architecture diminished, cellular atypia worsened, and clear cells increased in number. In the DNA analysis of the receptor genes, the clonal population increased in number. EBV nucleic acid sequences were found by either PCR or in situ hybridization in all examined nodes. The number of EBV-positive cells varied widely among the cases and throughout the course of the disease in the same patients. The analysis of EBV terminal repeats or lymphocyte-determined membrane antigen genes showed polyclonal populations of EB-infected cells. EBV-positive cells possessed intermediate- to large-sized nuclei, and the cells with large nuclei, especially, expressed latent membrane protein of EBV. These large cells varied in number among the cases. Double-labelling immunohistochemistry/in situ hybridization studies demonstrated that most of the EBV-positive cells expressed B-cell antigen (CD20). The presence of EBV seems to be associated with the selective defects of the immune system, rather than with the direct pathogenesis of angioimmunoblastic lymphadenopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1994.tb01376.x
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  • 3
    Electronic Resource
    Electronic Resource
    Budd-Chiari syndrome and Epstein-Barr virus (EBV) associated plasmacytoma in a patient with chronic active EBV infection (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 883-886 
    Details
    ISSN: 1432-1440
    Keywords: Epstein-Barr virus ; Epstein-Barr virus encoded RNA-1 ; Budd-Chiari syndrome ; Plasmacytoma ; Interleukin 2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 42-year-old Japanese man with chronic active Epstein-Barr virus (EBV) infection initially responded to treatment with interleukin-2 (IL-2). Six months later he developed thrombosis in the hepatic veins, and Budd-Chiari syndrome associated with severe hepatic damage was diagnosed. He also developed a solitary EBV-positive plasmacytoma in the right femur. Since these rare complications occurred after long-term IL-2 therapy, the possibility that long-term IL-2 therapy might cause Budd-Chiari syndrome and liver damage as well as EBV-associated plasmacytoma is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190746
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  • 4
    Electronic Resource
    Electronic Resource
    Primary afferent depolarization in the trigeminal spinal nucleus of cats (1977)
    Springer
    Experimental brain research 29 (1977), S. 45-56 
    Details
    ISSN: 1432-1106
    Keywords: Trigeminal nerve ; Primary afferent fiber ; Trigeminal spinal nucleus ; PAD ; Intra-axonal record
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intra-axonal recordings were made from trigeminal primary afferent fibers in the trigeminal spinal nuclei oralis and caudalis of cats. Primary afferent depolarization (PAD) was evoked in these afferents by stimulation of the trigeminal peripheral sensory branches (the frontal, infraorbital and lingual nerves), the cerebral cortex and the trigeminal spinal nucleus caudalis. The properties of the PAD, including the threshold, latency, receptive field (sensory branches effective for PAD induction) and frequency-following capacity, were studied with the following results: 1. Stimulation of all the peripheral branches tested as well as the cerebral cortex could evoke PAD in the same single fiber. The latency of the PAD evoked by stimulation of the nerve in which the fiber being recorded from was included was generally shorter than that evoked by other branches. The PAD evoked by peripheral nerve stimulation was assumed to be disynaptic in some cases. 2. The peripherally evoked PAD was chiefly attributable to low threshold afferents in the stimulated sensory branches of the trigeminal nerve. 3. The peripherally evoked PAD could follow stimulation at up to 30/sec, though the amplitude was reduced. 4. Stimulation of the nucleus caudalis could evoke PAD with disynaptic latency in the majority of the fibers terminating in the same nucleus, whereas it evoked PAD with mainly polysynaptic latency in the fibers terminating in the nucleus oralis. The results are discussed in relation to the neuronal circuitry responsible for induction of the trigeminal PAD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236874
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  • 5
    Electronic Resource
    Electronic Resource
    Analysis of the circuitry responsible for primary afferent depolarization in the trigeminal spinal nucleus caudalis of cats (1977)
    Springer
    Experimental brain research 29 (1977), S. 405-418 
    Details
    ISSN: 1432-1106
    Keywords: Trigeminal nerve ; PAD ; Trigeminal spinal nucleus caudalis ; Interneuron ; Subnucleus magnocellularis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Depth analysis was performed on the field potential evoked by stimulation of the infraorbital nerve in the trigeminal spinal nucleus caudalis and the subjacent lateral reticular formation of cats. It was shown by dye marking of the recording positions that each subnucleus of the nucleus caudalis (subnucleus marginalis, gelatinosus and magnocellularis) and the reticular formation could be differentiated from one another by the characteristics of the peripherally evoked field potentials. Responses of neurons were extracellularly recorded in the subnuclei gelatinosus and magnocellularis of the nucleus caudalis and in the reticular formation to stimulation of the trigeminal sensory branches (the frontal, infraorbital and lingual nerves), the nucleus ventralis posteromedialis of the thalamus and the cerebral cortex. The properties of the neurons were studied in relation to their thresholds, latencies, receptive fields (sensory branches effective for spike generation) and frequency-following capacities. These responses were then compared with properties of the PAD induced in the fibers terminating in the nucleus caudalis by similar peripheral and central stimulation. It was found that the neurons in the subnucleus magnocellularis were the most likely candidates for the interneurons mediating the peripherally evoked disynaptic PAD in the trigeminal nerve fibers terminating in the nucleus caudalis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236179
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  • 6
    Electronic Resource
    Electronic Resource
    The effects of pinealectomy and blinding on the circadian locomotor activity rhythm in the Japanese newt, Cynops pyrrhogaster (1993)
    Springer
    Journal of comparative physiology 172 (1993), S. 683-691 
    Details
    ISSN: 1432-1351
    Keywords: Pinealectomy ; Blinding ; Circadian rhythm ; Locomotor activity ; Newt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We examined the effects of pinealectomy and blinding (bilateral ocular enucleation) on the circadian locomotor activity rhythm in the Japanese newt, Cynops pyrrhogaster. The pinealectomized newts were entrained to a light-dark cycle of 12 h light and 12 h darkness. After transfer to constant darkness they showed residual rhythmicity for at least several days which was gradually disrupted in prolonged constant darkness. Blinded newts were also entrained to a 12 h light/12 h dark cycle. In subsequent constant darkness they showed free-running rhythms of locomotor activity. However, the freerunning periods noticeably increased compared with those observed in the previous period of constant darkness before blinding. In blinded newts entrained to the light/dark cycle the activity rhythms were gradually disrupted after pinealectomy even in the presence of the light/dark cycle. These results suggest that both the pineal and the eyes are involved in the newt's circadian system, and also suggest that the pineal of the newt acts as an extraretinal photoreceptor which mediates the entrainment of the locomotor activity rhythm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00195394
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  • 7
    Electronic Resource
    Electronic Resource
    Genetic changes in atypical hyperplasia and lymphoma with angioimmunoblastic lymphadenopathy and dysproteinaemia in the same patients (1994)
    Springer
    Virchows Archiv 425 (1994), S. 25-32 
    Details
    ISSN: 1432-2307
    Keywords: Angioimmunoblastic lymphadenopathy with dysproteinaemia ; Polymerase chain reaction ; T-cell receptor gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The transition between atypical hyperplasia and lymphoma with angioimmunoblastic lymphadenopathy and dysproteinaemia (AILD) was studied in serial lymp node biopsy specimens from five patients using DNA analysis with Southern blot analysis, polymerase chain reaction, chromosomal analysis, and immunophenotyping. The chromosomal analysis showed additional abnormalities as the disease progressed to those present initially, and immunological staining showed a corresponding increase in the numbers of CD4- and Ki67-positive cells. In the first biopsy from each patient a diagnosis of atypical hyperplasia with AILD was made and lymphoma excluding by the finding of only a few atypical lymphoid cells and the preservation of follicles with germinal centres. DNA analysis of lymph nodes at this stage showed either germ lines or oligoclonal rearrangements of the T-cell receptor (TCR) and immunoglobulin heavy chain genes. In the final biopsy, when a diagnosis of lymphoma with AILD was made, either a monoclonal rearrangement of the TCR was observed or one of the rearranged bands had increased in density. These results suggest selective proliferation of a clone of abnormal cells may account for the progression of atypical hyperplasia to lymphoma with AILD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00193945
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  • 8
    Electronic Resource
    Electronic Resource
    Early malignant histiocytosis of the intestine: an autopsy report (1994)
    Springer
    Virchows Archiv 424 (1994), S. 327-330 
    Details
    ISSN: 1432-2307
    Keywords: Autopsy ; Early malignant histiocytosis of the intestine ; Cell clonality ; Polymerase chain reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 63-year-old man with malignant histiocytosis of the intestine died 3 days after gastrectomy for early gastric adenocarcinoma. Malignant histiocytosis of the intestine was unexpectedly found at autopsy. The intestine was thickened with mucosal erosions. Histologically, a few atypical large histiocyte-like cells were found in focal aggregates in the mucosa. These large cells expressed the T-cell antigen and monoclonality was demonstrated by the polymerase chain reaction showing variable-joining segment rearrangement in the T-cell receptor delta-chain gene. Malignant histiocytosis of the intestine was thus diagnosed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00194619
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  • 9
    Electronic Resource
    Electronic Resource
    Analysis of herpesvirus genomes in Kikuchi's disease (1994)
    Springer
    Virchows Archiv 424 (1994), S. 437-440 
    Details
    ISSN: 1432-2307
    Keywords: Kikuchi's disease ; Herpes virus ; Lymph node
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the cervical lymph nodes of 30 patients with Kikuchi's disease and 15 patients with nonspecific lymphadenitis, using Southern blot analysis and polymerase chain reaction (PCR) to identify human herpesviruses such as Epstein-Barr virus (EBV), cytomegalovirus, herpes simplex virus, and varicella-zoster virus. By Southern blot analysis, no virus DNA was recognized, but 16 of the 30 nodes from patients with Kikuchi's disease and 8 of the 15 nodes from patients with non-specific lymphadenitis showed amplified EBV DNA by PCR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190567
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  • 10
    Electronic Resource
    Electronic Resource
    Analysis of adhesion molecules in Ki-1 anaplastic large-cell lymphoma (1994)
    Springer
    Virchows Archiv 425 (1994), S. 33-39 
    Details
    ISSN: 1432-2307
    Keywords: Ki-1 anaplastic large-cell lymphoma Adult T-cell leukaemia/lymphoma ; ATLL ; Adhesion molecules
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We analysed the expression of adhesion molecules on lymphoma cells in 13 patients with Ki-1 (CD30)-positive anaplastic large-cell lymphoma (Ki-1 ALCL; lymph nodes in 6, extranodal tumours in 6, and both lymph nodes and bone in 1). Very late activation antigen (VLA)-α4 (CD49d) and Hermes lymph node homing receptor (CD44) were constantly expressed in all specimens, and intercellular adhesion molecule-1 (ICAM-1; CD54) was frequently expressed in 10 of the 14 specimens. The expressions of lymphocyte function-associated antigen-1α (LFA-1α; CD11a) and VLA-α5 (CD49e) occurred in 5 of 14 and 4 of 14 specimens, respectively. The expressions of VLA-α2 (CD49b), endothelial leukocyte adhesion molecule-1, neural cell adhesion molecule (CD56) and E cadherin were always lacking. VLA-α6 (CD49f) was absent in all but one specimen. The expression of VLA-α5 on Ki-1 ALCL was high in subcutis-cutis but absent in lymph nodes. Furthermore, in one case, LFA-1α was detected in the primary lymph node, but was absent in a metastatic bone lesion. These results suggest that the expression of ICAM-1 is partially responsible for aleukemic behaviour in Ki-1 ALCL and, moreover, that the Ki-1 ALCL cells modify their expression of adhesion molecules at each of the involved organs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00193946
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