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  • Articles: DFG German National Licenses  (4)
  • 1990-1994  (4)
  • Analytical Chemistry and Spectroscopy  (3)
  • non-invasive method  (1)
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  • Articles: DFG German National Licenses  (4)
Material
Years
  • 1990-1994  (4)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 44 (1993), S. 415-421 
    ISSN: 1432-1041
    Keywords: Clinical pharmacology ; Systolic time intervals ; dose effect relationship ; non-invasive method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Conclusion Heart rate-corrected STI integrate and reflect changes in ventricular inotropy, preload and afterload. STI represent a global method for the evaluation of cardiovascular performance, provided very well controlled study designs, including positive and negative controls and strictly standardised conditions are followed. STI are accurate, economic, reproducable and are very sensitive. They represent a useful non-invasive tool in clinical pharmacology for assessing the influence of drugs, their dose-effect relationships, and the time course of their effects on the cardiovascular system.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 23 (1994), S. 406-416 
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: This study shows that fast atom bombardment (FAB) in combination with collisional activation and tandem mass spectrometric techniques is useful for the characterization of, and the differentiation between, O-diglycosyl, O-C- diglycosyl, and di-C-glycosyl flavonoids. A quick differentiation between the three types of glycosyl flavonoids is possible by simply examining FAB mass spectra. Low-energy product ion spectra of [M + H] + ions have been used for determining the carbohydrate sequence in O-diglycosyl flavonoids and characterizing the terminal mono-saccharide in O-C-diglycosyl flavonoids. The data obtained for per-O- deuterated precursor ion species of O-diglycosyl flavonoids indicate that O-linked hydrogen atoms are involved in the formation of Yn + ions. High-energy product ion spectra of [M + H] + ions enable further characterization and differentiation of isomeric di-6,8-C-glycosides.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 21 (1992), S. 213-221 
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The present study deals with the use of liquid secondary ion mass spectrometry in combination with collisionally activated dissociation and linked scanning at constant B/E for differentiation and structural analysis of 6-C- and 8-C-glycosidic flavonoids in the positive ion mode. Flavonoids of mono-C-glycosidic nature were investigated. Special emphasis is given to the rationalization of fragment ions which allow differentiation between isomers.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 21 (1992), S. 408-410 
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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