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  • Articles: DFG German National Licenses  (2)
  • 1990-1994  (2)
  • Electrical impedance  (1)
  • Heterogeneity  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 68 (1990), S. 223-236 
    ISSN: 1432-1440
    Keywords: Diagnosis ; HTK solution ; Heterogeneity ; Ischemia ; Kidney ; Lithium ; Magnesium ; Potassium ; Proximal tubule ; Organ protection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Several functional parameters were applied in an experimental model of ischemia to test the ability to localize the distribution of tubular lesions. Canine kidneys were perfused with protective solutions and rendered ischemic for definite periods. Renal function was determined during a subsequent 3-h reperfusion. The pattern and the extent of renal injury were influenced by varying the duration of ischemia and by modifying the protective solution used. The results suggest that by employing an appropriate selection of parameters it is possible to allocate renal injury to definite sections of the tubules. According to such an evaluation, under protection with HTK-solution, the proximal tubule limits the tolerance of renal ischemia. The thick ascending limb shows some vulnerability that is aggravated by disadvantageous modifications of the protective solution and that may become more pronounced in the course of reperfusion. In contrast, more distal parts of the nephron retain a remarkable reserve transport capacity after a tolerable level of ischemia.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-2451
    Keywords: Electrical impedance ; Liver ischemia ; Liver transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 22 Lebern, die zur Transplantation beim Menschen perfundiert und entnommen wurden, wurde das Verfahren der nichtinvasiven Messung der bioelektrischen Impedanz prospektiv angewendet. Im Verlauf der Messung sollten Rückschlüsse auf einen möglichen Ischamieschaden der Organe gezogen wurden. Die Meßwerte wurden zur Funktion der Lebern, den Ischämiezeiten und den Konservierungsverfahren in Beziehung gesetzt. Für die Impedanz ergaben sich in vivo bei 192 Hz im Mittel 620 Ohm, für den Phasenwinkel bei 5 kHz −7,4°. Diese Werte entsprachen denen eines Kollektivs von 72 lebergesunden Patienten (mittels Multivarianz aus einem untersuchten Kollektiv von 132 Patienten ermittelt), die intraoperativ durchgeführt wurden. Die 22 Transplantatlebern wurden in den Ischämiephasen mit jeweils mindestens 5 Meßpunkten weiterverfolgt. Das Verfahren wurde als geeignet befunden, schwere hepatozelluläre Schäden im Verlauf der Kaltischämie zu erfassen.
    Notes: Abstract In 22 human donor livers the measurement of the non-invasive bioelectrical impedance was performed prospectively to evaluate the degree of tissue damage sustained during cold ischemia. The results of the measurement were correlated with liver function, the method of organ preservation and the period of ischemia. The impedance was measured in vivo as 620 ohm (at 192 Hz), the phase angle as −7.4° (at 5 kHz). The results were compared with the data obtained from 72 patients who underwent elective laparotomies. The 22 donor livers were studied further during ischemia. The method was found to be a reliable way of detecting severe damage to the hepatocytes during the cold ischemia.
    Type of Medium: Electronic Resource
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