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  • Articles: DFG German National Licenses  (5)
  • 1990-1994  (5)
  • 1
    Electronic Resource
    Electronic Resource
    A general analysis of reactive ion transport in dynamic equilibrium (1993)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 99 (1993), S. 6907-6914 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: In a drift-tube analysis, an asymptotic solution for the transport of inter-reacting multiple ion swarms approaching to dynamic equilibrium is proposed. The solution describes a set of similar Gaussian profiles with two common "equilibrium'' transport coefficients. Although all the profiles apparently aggregate to the same location, there exists a slight peak difference between arbitrary two spectra. The difference holds even in the equilibrium. A generalized equilibrium constant is defined by the quotient of two reaction-frequency determinants. Those four kinetic constants are uniquely determined from the kinetic coefficients of all ion species without any influence of the initial conditions. The discrepancy between the thermal equilibrium and dynamic equilibrium is briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.465834
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis of two ion swarms in dynamic equilibrium: Simultaneous determination of two drift velocities and two reaction frequencies (1994)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 101 (1994), S. 2949-2952 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: In a drift-tube study, four simple formulas, based on a dynamic equilibrium analysis of two gaseous ion swarms, are proposed to determine simultaneously the forward and reverse reaction frequencies together with two drift velocities. The formulas are put to the test for (N+4,N+2)/N2 system with two arrival time spectra (ATS) generated from the experimental data previously reported at E/N=150 Td (the ratio of electric field strength to gas number density: 1 Td=10−17 V cm2). The percent differences between the data and the determined values are estimated to be 0.8%, −1.4%, 6.8%, and 4.9%, for the drift velocities of N+4 and N+2 ions and the forward and reverse reaction frequencies, respectively. For the same system, two experimental ATS obtained at 180 Td by McKnight et al., being supposedly in near equilibrium, are directly examined by this method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.467607
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Mosaicism of mitochondria in mitochondrial myopathy: an electronmicroscopic analysis of cytochrome c oxidase (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 642-648 
    Details
    ISSN: 1432-0533
    Keywords: Mitochondrial myopathy ; Cytochrome c oxidase ; Mosaicism of mitochondria ; Electron microscopic histochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electron microscopic histochemistry was applied to the study of cytochrome c oxidase activity in each mitochondrion of biopsied muscles from four patients with mitochondrial myopathy [one case of fatal infantile mitochondrial myopathy, one case of myoclonus epilepsy associated with ragged-red fibers (MERRF), and two cases of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)]. In the patient with fatal infantile mitochondrial myopathy, intercellular heterogeneity of mitochondria was recognized. In the three patients with either MERRF or MELAS, cytochrome c oxidase activity was segmentally changed from positive to negative within single muscle fibers. In the two patients with MELAS, small groups of positive-stained mitochondria were located among negative-stained mitochondria in the negative segment of a few muscle fibers. These findings revealed that there were heterogeneous populations of normal and abnormal mitochondria intracellularly or intercellularly within the muscles of these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307633
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Quantitative evaluation of electron transport system proteins in mitochondrial encephalomyopathy (1993)
    Springer
    Acta neuropathologica 85 (1993), S. 370-377 
    Details
    ISSN: 1432-0533
    Keywords: Mitochondrial myopathy ; Cytochrome c oxidase deficiency ; Immunoelectron microscopy ; In situ hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The levels of mitochondrial electron transport system proteins cytochrome c oxidase (COX) and complex III were measured in muscle fibers of patients with mitochondrial encephalomyopathy using quantitative immunoelectron microscopy. In a patient with Leigh's encephalopathy, immunoreactive COX protein was decreased to 20% of the normal mean value in all muscle fibers examined, while the amount of complex III was within the normal range. In a patient with fatal infantile COX deficiency, the level of COX protein was found to be decreased to 27–40% of the normal value in all muscle fibers examined. In patients with mitochondrial myopathy, encephalopathy, lactic acidosis associated with stroke-like episodes (MELAS) and chronic progressive external ophthalmoplegia (CPEO), COX protein levels were decreased to 20% of normal in muscle fibers lacking COX activity. In normal fibers, however, COX protein levels were also normal. The amount of complex III protein was normal in COX-deficient muscle fibers. In two patients, in situ hybridization was performed for detection of mitochondrial mRNA. Mitochondrial mRNAs were found to be abundant in muscle fibers with decreased COX protein, suggesting a defect at the mitochondrial protein-synthesis level in a COX-deficient muscle fiber.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334446
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Histamine levels and clonic convulsions of electrically-induced seizure in mice: the effects of α-fluoromethylhistidine and metoprine (1992)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 346 (1992), S. 40-45 
    Details
    ISSN: 1432-1912
    Keywords: Histamine ; l-Histidine ; α-Fluoromethylhistidine ; Pyrilamine ; Electrically-induced seizure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of this study was to investigate the possible role of the central histaminergic neuron system in electrically-induced seizure in mice. For this purpose, we examined the effects of intraperitoneal (i. p.) injections of histaminergic agents, such as l-histidine, metoprine, and α-fluoromethylhistidine (FMH), on electrically-induced seizure. l-Histidine decreased the duration of clonic convulsion in electrically-induced seizure, but not affected that of tonic convulsion. This effect of l-histidine was antagonized by pretreatment with FMH, indicating that it was due to histamine formed by decarboxylation of l-histidine in the central nervous system. The anticonvulsive effect of l-histidine was also reduced by the H1-antagonist pyrilamine, but not by the H2-antagonist zolantidine, indicating that the effect on electrically-induced seizure is mediated through central H1-receptors. Metoprine, which increased the histamine levels in the cerebral cortex, diencephalon and midbrain of mice, decreased the duration of clonic convulsions dose-dependently. Conversely, FMH, which decreased the brain histamine levels, increased the duration of clonic convulsions. Good inverse correlations were found between the duration of clonic convulsions and brain histamine levels, especially in the diencephalon: the histamine levels were inversely proportional to the duration of clonic convulsions. No correlation was found between the duration of tonic convulsions and brain histamine levels. These results suggest that the histaminergic neuron system is important in inhibition of the duration of clonic convulsion on electrically induced seizure in mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167568
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    Paper (German National Licenses)
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