ISSN:
1420-908X
Keywords:
Key words: Brain histamine — Growth hormone-blood — Growth rate — Portacaval anastomosis — Prolactin-blood
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract. Objective and Design: Histamine can modulate feeding behaviour and hormone release; therefore we examined the hypothalamic histamine system, the growth pattern and the serum levels of prolactin and growth hormone in rats with portacaval anastomosis (PCA).¶Material: The growth rate of 30 PCA- and 30 sham-operated male Han:Wistar rats was monitored for 6 months. Thirteen sham and 9 PCA rats were used for biochemical studies.¶Methods: Histamine was assayed by HPLC, tele-methylhistamine by GC-MS, prolactin and growth hormone by RIA. Student's t-test was used to compare the groups.¶Results: Six months after surgery, the PCA rats exhibited marked growth retardation (weight gain of 20 g vs. 140 g for the sham rats; p 〈 0.001), increased plasma levels of prolactin (9.7 ± 2.4 vs. 3.6 ± 0.6; p 〈 0.01) and unaltered growth hormone levels (6.2 ± 0.5 vs. 8.1 ± 1.0). A six-fold elevation of histamine concentration (29.5 ± 3.9 vs. 4.8 ± 0.4; p 〈 0.001) and a two-fold increase of tele-methylhistamine levels (1.8 ± 0.1 vs. 0.8 ± 0.02; p 〈 0.001) were found in hypothalamus.¶Conclusion: We suggest that increased histaminergic activity in the hypothalamus may be involved in the development of growth retardation and in the enhanced basal secretion of prolactin in male rats with long-term PCA.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s000110050417
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