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Digitale Medien

Differential effects of cimetidine and ranitidine on imipramine demethylation and desmethylimipramine hydroxylation by human liver microsomes (1986)

Spina, E. ; Koike, Y.

Springer

European journal of clinical pharmacology 30 (1986), S. 239-242

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Details

ISSN: 1432-1041

Schlagwort(e): cimetidine ; ranitidine ; imipramine demethylation ; desmethylimipramine hydroxilation ; human liver microsomes ; debrisoquine hydroxylase

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary The effect of cimetidine and ranitidine on the demethylation of imipramine (IMI) and on the hydroxylation of desmethylimipramine (DMI) was studied in microsomes from four human livers. Cimetidine inhibited both demethylation of IMI and 2-hydroxylation of DMI, whilst the effect of ranitidine was not statistically significant. 2-hydroxylation of DMI is probably mediated by debrisoquine hydroxylase, a cytochrome P-450 isozyme that is monogenically controlled. The results suggest that cimetidine inhibits this enzyme.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00614311

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