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  • Articles: DFG German National Licenses  (2)
  • 1985-1989  (2)
  • 1,25 (OH)2D3  (1)
  • Adrenal medulla  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Calcium and inorganic phosphate secretion of rat ileum in vitro (1988)
    Springer
    Research in experimental medicine 188 (1988), S. 139-149 
    Details
    ISSN: 1433-8580
    Keywords: Intestinal transport ; 1,25 (OH)2D3 ; Calcium ; Phosphorus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The unidirectional ileal transport of calcium (Ca) and inorganic phosphorus (Pi) of rats was measured in vitro with the modified Ussing technique. Animal preparation included 5/6 nephrectomy and EHDP treatment. They were compared to controls as well as to 1,25 (OH)2D3 supplemented rats. The results show that the ileum is a secretory organ for Ca and Pi, the serosa to mucosa transport (Jsm) exceeds the mucosa to serosa transport (Jms). Ca and Pi transport in sm direction is 1,25 (OH)2D3 independent but exhibits a mutual strong correlation. Our observations together with published data are in favor of mainly paracellular, non electrogenic sm transport of both ions. However, the factor controlling sm transport of Ca and Pi remains unidentified. The mucosa to serosa transport (Jms) in the ileum is low for both ions. Ca ms is stimulated by 1,25 (OH)2D3, Pi ms is unchanged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852270
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    An electrophysiological investigation of the characteristics and function of GABAA receptors on bovine adrenomedullary chromaffin cells (1989)
    Springer
    Pflügers Archiv 415 (1989), S. 95-103 
    Details
    ISSN: 1432-2013
    Keywords: GABAA receptors ; Bovine chromaffin cells ; Nicotinic receptors ; Adrenal medulla ; Catecholamine secretion ; Patch-clamp technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The characteristics and function of γ-aminobutyric acidA (GABAA) receptors expressed on bovine chromaffin cells in culture have been investigated using patch-clamp techniques. In voltage-clamped whole-cells, locally applied GABA (100 μM) evoked a transmembrane chloride current which demonstrated outward rectification. The amplitude of such currents was reversibly suppressed by the GABAA receptor antagonists bicuculline, picrotoxin and RU5135, and enhanced by the general anaesthetic propanidid. Glycine (100 μM) and baclofen (100 μM) were ineffective as agonists. In support of a physiological role for GABA in the adrenal medulla, the co-existence of GABAA and nicotinic acetylcholine (ACh) receptors was demonstrated on whole cells and outside-out membrane patches. Ionophoretically applied GABA reduced the amplitude of depolarization and action potential discharge occurring in response to locally applied ACh (100 μM), but had no effect upon the underlying ACh-induced current. In addition, an excitatory action of GABA was demonstrated by recording action potential waveforms in cell-attached patches. The results are discussed in the context of a GABA-ergic regulation of catecholamine secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00373146
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    Paper (German National Licenses)
    Fulltext
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