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  • Articles: DFG German National Licenses  (32)
  • 1970-1974  (14)
  • 1955-1959  (18)
  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 77 (1955), S. 820-821 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 29 (1972), S. 73-84 
    ISSN: 1432-0738
    Keywords: 2-Chloroethyl Isocyanate ; Generation of Vapour Atmospheres ; Inhalation Toxicity ; Threshold Limit Values ; orter: 2-Chloräthylisocyanat ; Erzeugung von Dampf-Luft-Gemischen ; Inhalationstoxicität ; Maximale Arbeitsplatzkonzentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die akute orale Toxicität von 2-Chloräthylisocyanat (CAIC) beträgt 396 mg/kg für männliche Ratten und 630 mg/kg für weibliche Mäuse. Am Kaninchenauge löste die außerordentlich geringe Menge von 5μl CAIC schwere Reizerscheinungen vor allem an der Conjunctiva aus. Auch die irritative Wirkung an der Kaninchenhaut war beträchtlich. In inhalationstoxikologischen Versuchen, deren Methodik durch Beschreibung eines einfachen Verfahrens zur Beladung von Luft ergänzt wurde, erwies sich CAIC als Reizgas ohne erkennbare systemischtoxische Wirkung. Die LC50 für Ratten beträgt bei sechsstündiger Exposition 6,3 ppm. In zwei subakuten Versuchen über 10 Tage mit Konzentrationen von 3,1 und 3,8 ppm überlebten alle Ratten. Zehn Tage nach Versuchsende wurden außer im Respirationstrakt (Tracheobronchitis. Bronchopneumonie) histologisch keine pathologischen Veränderungen gefunden. Es wird eine maximale Arbeitsplatzkonzentration (MAK) von 0,02 ppm vorgeschlagen.
    Notes: Abstract The acute oral toxioity of 2-chloroethyl isocyanate (CAIC) is 396 mg/kg for male rats and 630 mg/kg for female mice. The extremely small quantity of 5 μl CAIC caused severe irritation in the eyes of rabbits, particularly of the conjunctiva. The skin was also affected considerably. Inhalation experiments, involving a new version of a proven method for generating air-vapour mixtures, produced no evidence of systemic toxicity, but let CAIC be classified as an irritant vapour to the respiratory tract. The LC50 for rats is 6.3 ppm after exposure for 6 h, while rats in two experiments involving ten-day exposures to vapour concentrations of 3.1 and 3.8 ppm, respectively, survived. After a fortnight's withdrawal following each experiment, histological examinations showed tracheobronchitis and bronchopneumonia but no pathological change in any other organ examined. A threshold limit value (TLV) of 0.02 ppm is suggested.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 1 (1970), S. 148-150 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 14 (1958), S. 107-109 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The active principle ofPsilocybe mexicana Heim, a mexican mushroom with hallucinogenic properties, has been isolated in crystalline form. The compound has been given the namePsilocybin; it possesses indole characteristics and contains phosphorus. A second substance, closely related toPsilocybin but found only in traces, has been calledPsilocin.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 15 (1959), S. 101-102 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Psilocin, a by-product of Psilocybin which is the active principle of hallucinogenic mushrooms, has been identified as 4-hydroxy-dimethyltryptamine.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 14 (1958), S. 397-399 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The structure of Psilocybin, the psychotropic active principle of the Mexican mushroomPsilocybe mexicana Heim, has been elucidated. Psilocybin is the phosphoric acid ester of 4-hydroxy-dimethyltryptamine. This structure was confirmed by total synthesis.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 26 (1970), S. 1342-1343 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Diazoacetylcholinebromide was used for affinity labelling of the cholinergic receptors of endplates in the mouse diaphragm. Under irradiation by light (Hg-high-pressure-lamp), irreversible depolarizing block of neuromuscular transmission developed. Acetylcholinesterase was influenced only by much higher concentrations, which demonstrates different localizations of the active enzyme center and the cholinergic receptor.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of wildlife research 18 (1972), S. 185-212 
    ISSN: 1439-0574
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Lung 142 (1970), S. 7-19 
    ISSN: 1432-1750
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über Erfahrungen in Prophylaxe und Behandlung schwerer postoperativer Nachblutungen in der Thoraxchirurgie berichtet. Ist es zu einer größeren Nachblutung gekommen, so beseitigt die möglichst frühzeitige Rethorakotomie mit der Ausräumung der Coagel die Einflußstauung und den Blutungsschock und bringt optimale funktionelle Ergebnisse. Darstellung anhand der Operationsstatistik von ca. 1967 Fällen in 6 Jahren (1963/1968). Durch eine postoperative Blutungsprophylaxe mit Trasylol® und Trans-AMCHA konnte die Zahl der schweren Nachblutungen bei Eingriffen der Thoraxchirurgie gegenüber Trasylol® und ACS von 2,3% auf unter 1% gesenkt werden. Der Beginn der Thrombo-Embolieprophylaxe wurde dabei auf den Operationstag oder 1. postoperativen Tag vorverlegt. Dosierung und Nebenwirkungen sowie die theoretischen Grundlagen werden besprochen. In letzter Zeit haben Bloedner, Wachsmuth und Viereck und auch Wolfart u. Mitarb. über postoperative Blutungen in der Thoraxchirurgie, ihre Prophylaxe und Behandlung berichtet. Dabei erscheinen uns folgende Punkte wichtig: 1. Die postoperative Blutung ist unter den Gegebenheiten des Thorax immer ein ernstes Problem. 2. Als Blutungsmechanismus ist Hyperfibrinolyse häufig und anscheinend zunehmend anzunehmen. 3. Zur Behandlung ist baldigste Rethorakotomie mit Ausräumung der Coagel die beste Methode. 4. Blutungsprophylaxe kann die funktionellen Ergebnisse verbessern und die Thromboserate sowie die Hepatitisrate herabsetzen. Im eigenen Krankengut haben wir in der Zeit von 1963–1968, also in 6 Jahren, unter 1967 Thorakotomien in 32 Fällen wegen einer Blutung eine Rethorakotomie mit akuter Indikation 6–36 Std nach dem ersten Eingriff durchgeführt. Über das Krankengut und die Eingriffe orientieren die Tabellen 1 und 2. Dabei wurde die Indikation zur Rethorakotomie immer dann gestellt, wenn a) größere Blutmengen (mehr als 1000 ml) in wenigen Stunden in der Saugdrainage abliefen, b) die Röntgenkontrolle ein zunehmendes Hämatom zeigte und größere Coagelmassen im Thorax anzunehmen waren. Bei 32 Rethorakotomien fanden wir dabei nur 6mal (= 19%) eine Gefäßblutung, die versorgt werden konnte. (In 3 Fällen lagen arterielle Blutungen aus Brustwandgefäßen vor, 2 Fälle hatten eine Blutung aus einer kleinen Zwerchfellarterie in den Bauchraum und Thorax und 1mal lag eine Lungenvenenblutung vor.) In allen übrigen 26 Fällen (= 81%) handelte es sich um diffuse Sickerblutungen. Die Komplikation war allein durch Ausräumen der Blutcoagel und durch Auffüllen des Kreislaufes zu beherrschen. Nur selten kam es nach der Hämatomausräumung nochmals zu einer nennenswerten Blutung.
    Notes: Abstract This paper reports experiences with prophylaxis and treatment of postoperative hemorrhage in thoracic surgery. In a series of 1967 thoracotomies performed for a variety of reasons between the years 1963 and 1968, 32 urgent secondary interventions were necessary 6 to 32 hours postoperatively. In only 6 patients were these interventions thought to be due to localized bleeding. In 26 cases (81%) hemorrhage and shock were cured by removal of blood clots only. In case of hemorrhage complications, it seems, that a secondary thoracotomy, performed soon after, is the best treatment to bring about early recovery and best functional results. If it is supposed that 80% of these hemorrhages have a causal connection with fibrinolysis a postoperative prophylaxis with antifibrinolytic agents should be useful. We observed less bleeding complications, when Trasylol® and 1-aminocapromic acid were used; an even greater diminution was noted (from 2.3% to less than 1%), when Trasylol® and aminomethylcyclohexane acid were given from 24 to 48 hours (or longer) postoperatively. There was a remarkable diminution of fluids discharged into suction containers, less conserved blood was needed, and postoperative hepatic and thrombo-embolic complications decreased (Hepatitis 1%, Embolism 0,3%). In 500 cases during the years 1968 and 1969 we encountered only two incidents of hemorrhage. Most of the operations during the last two years (including lobectomies for tuberculosis) were performed without conserved blood. Embolism and hepatitis were also absent. The prophylaxis for embolism was usually started 24 hours postoperatively (in selected cases somewhat earlier). Heparine and Dicumarol were used in the follow-up treatment.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 260 (1973), S. 35-45 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Differential cross sections for 10 MeV deuterons, elastically scattered from24,26Mg and28,30Si have been measured. The scattering data have been analysed systematically in the framework of the optical model. It was found, that an uniform set of parameters, which is able to reproduce reasonably the angular distributions for the four nuclei, does not exist. Both the Mg distributions as well as both the Si distributions, however, can be described well with one set of parameters, respectively.
    Type of Medium: Electronic Resource
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