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  • Articles: DFG German National Licenses  (92)
  • 1970-1974  (92)
  • Computational Chemistry and Molecular Modeling  (51)
  • Electron Microscopy  (41)
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  • Articles: DFG German National Licenses  (92)
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Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Étude clinique, histologique et ultrastructurale de quatre cas de leucodystrophie métachromatique infantile et juvénile (1972)
    Springer
    Acta neuropathologica 21 (1972), S. 23-38 
    Details
    ISSN: 1432-0533
    Keywords: Leucodystrophy Metachromatic ; Electron Microscopy ; Prismatic Deposits ; Brain ; Peripheral Nerve ; Kidney ; Rectum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Clinical history, light and electron microscopy findings are reported in four cases of infantile metachromatic leucodystrophy. By electron microscopy, the authors describe the various types of lesions and the different lipid deposits noticed in the central and peripheral nervous system, in the kidney and rectum. They stress the prismatic lipid deposits observed not only in the cerebral white matter and in the kidney but in the peripheral nerves as well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687997
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    SCF perturbation theory and intermolecular interactions (1972)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 6 (1972), S. 555-574 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A self-consistent perturbation theory is derived in the framework of Roothaan's MOLCAO procedure for closed shell systems. Contrary to previous investigations which have considered only one particle perturbations, two particle perturbation operators are considered. Expressions for the first-order density matrix and first- and second-order energy corrections are obtained. A diagram formulation of the complete perturbation expansion is presented.The results are applied to the treatment of the intermolecular interaction problem. The interaction energy is represented as a sum of several contributions: Coulomb, exchange, resonance, polarization and exchange repulsion. A semi-empirical version of the theory is suggested which explicitly involves all the physically significant energy terms and may be useful for the investigation of complex systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560060317
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Interaction of two H2 molecules: Comparative study of various perturbation procedures (1974)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 8 (1974), S. 467-489 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A variational calculation of the interaction between two H2 molecules using minimal basis set of 1s functions is performed to check the efficiency of various versions of the perturbation theory for intermolecular interactions. The matrix procedure starting with the zero-order Hamiltonian which is symmetric with respect to intermolecular electron permutations shows better convergence than the procedures using nonsymmetric zero approximations. This conclusion follows from the calculations of ground state and four lowest excited states for three geometric configurations of the H4 system. The behaviour of the potential curves is interpreted in terms of symmetric perturbation theory. The various contributions to the interaction energy are considered in detail. The importance of charge transfer states for the description of the intermediate range of intermolecular separations is specially emphasized.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560080312
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Intermolecular interactions in the region of small overlap (1972)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 6 (1972), S. 23-45 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In order to treat the interaction energy of two molecules a standard Rayleigh-Schrödinger perturbation theory is developed. The Hartree-Fock functions of the separated molecules are used as one particle basis functions, the initial set of states being truncated and non-orthogonal. The non-orthogonality is included into the Hamiltonian by orthogonalization of the basis set. The unperturbed Hamiltonian is chosen so that it possesses the correct symmetry properties with respect to the electron permutations between different molecules. The procedure of this kind automatically results in the appearance of charge transfer states.A graphical technique is elaborated which is a modified version of the Feynman-Goldstone technique and provides a convenient representation of the interaction energy contributions of any order. As an example the first- and the second-order diagrams are considered.A correct expression for the dispersion energy is obtained which differs by a factor from that of the theory using a nonsymmetrical zero approximation.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560060103
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Additional electron microscopic observations on two cases of Batten-Spielmeyer-Vogt disease (Neuronal ceroid-lipofuscinosis) (1971)
    Springer
    Acta neuropathologica 17 (1971), S. 85-102 
    Details
    ISSN: 1432-0533
    Keywords: Neuronal Ceroid Lipofuscinosis ; Electron Microscopy ; Membranous and Fingerprint Inclusions ; Hypertrophied Cortical Astrocytes ; Nuclear Bodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommaire Deux cas de la maladie de Batten-Spielmeyer-Vogt (idiotie amaurotique familiale juvénile) ont été étudiés en microscopie électronique, histochimiquement et biochimiquement. Le premier cas, dont l'histoire clinique a débuté à l'âge de 3 ans, a révélé des inclusions cytoplasmiques dans les cellules neuronales et gliales, composées de membranes fréquemment disposées en paires. La structure de ces inclusions était identique à l'examen du matériel autopsié six mois plus tard. Dans le deuxième cas, dont l'histoire clinique date de 4 ans et 4 mois, les inclusions étaient plus pléomorphes: elles étaient en général plus denses en électronique et comportaient fréquemment un élément à l'aspect d'«empreintes digitales». Quelques inclusions membraneuses semblables à celles du premier cas y ont également été retrouvées. En outre ont été observées une hypertrophie cytoplasmique prononcée des astrocytes corticaux, et une grande fréquence de cils, de corps basaux et de corps nucléaires dans ces astrocytes. Un paquet de filaments intranucléaires a été observé dans un neuron. Les données neurochimiques n'ont révélé aucune abnormalité dans les lipides ou les protéines du premier cas, ou dans les gangliosides du second. Malgré les différences morphologiques qui les caractérisent, la présence simultanée des deux types d'inclusions cytoplasmiques dans le même cas suggère qu'elles peuvent représenter des stages divers dans l'évolution du même processus fondamental. Il est possible que ce soit l'âge de la cellule nerveuse, lors de l'atteinte métabolique dont elle est l'object, qui détermine ces différences.
    Notes: Summary Electron microscopic, histochemical and neurochemical studies on two cases of Batten-Spielmeyer-Vogt disease (juvenile amaurotic familial idiocy) are presented. In the first case, with the clinical onset at the age of 3 years, cytoplasmic neuronal and glial inclusions consisted of membranous bodies, the membranes of which were frequently paired. The fine structure of these inclusions was unaltered when examined in autopsy material 6 months later. In case 2, with the clinical onset at 4 years and 4 months, the inclusions were more pleomorphic: they were usually more electron-dense, and frequently showed a characteristic “fingerprint” pattern component. A few membranous inclusions resembling those in case 1 were also present. Additional findings included marked cytoplasmic hypertrophy of inclusion-containing cortical astrocytes, and frequent cytoplasmic cilia, basal bodies, and nuclear bodies in the hypertrophic astrocytes. A packet of intranuclear filaments was found in one neuron. Neurochemical studies failed to reveal any abnormality of lipid or protein pattern in case 1, or of ganglioside pattern in case 2. Despite the morphological differences between the two types of cytoplasmic inclusions, the presence of both types within the same case suggests that they may represent different stages in the evolution of a single process. It is conceivable that such differences are related to the age of the neuron when the postulated intracellular defect first becomes manifest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687485
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Herpes virus hominis type 2 and intranuclear tubular structures in organized nervous tissue cultures (1972)
    Springer
    Acta neuropathologica 22 (1972), S. 170-179 
    Details
    ISSN: 1432-0533
    Keywords: Herpes Virus, Type 2 ; Tissue Culture ; Intranuclear Tubules ; Microtubular Structures ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mature explants of mouse spinal cord and ganglia have been infected with Herpes virus hominis type 2. After 48 h, a high titer of virus was detected in the explant and typical herpes-like particles were seen by electron microscopy. They were more numerous in sensory neurons and Schwann cells than in the CNS possibly because of a more rapid propagation through the extracellular space in spinal ganglia. In the infected nuclei, besides the naked particles, numerous tubular formations were found, apparently resulting from virus infection and specific for herpes type 2. Their dimensions and fine structure are illustrated and compared to other microtubular formations. In the cytoplasm of theneurons, a dramatic disorganisation occurred and, in the Schwann cell, the plasma membrane underwent disruption. Consequently, the normal axon — Schwann cell intimate contact was lost.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688783
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    „Fingerprint inclusions” in muscle fibres in dystrophia myotonica (1973)
    Springer
    Acta neuropathologica 24 (1973), S. 62-67 
    Details
    ISSN: 1432-0533
    Keywords: Dystrophia Myotonica ; Electron Microscopy ; „Fingerprint Inclusions” in Muscle Fibres
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary „Fingerprint inclusions” were observed in numerous muscle fibres of 3 cases of dystrophia myotonica studied by electron microscopy in two different laboratories. They consist of parallel or concentric palisades of short electron dense linear elements. Identical „fingerprint inclusions” were reported in two other clinical conditions and cannot therefore be regarded as specific for a particular muscle disease. Their origin and significance remain obscure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691419
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Un cas de dystrophie neuroaxonale infantile ou maladie de Seitelberger (1971)
    Springer
    Acta neuropathologica 18 (1971), S. 327-341 
    Details
    ISSN: 1432-0533
    Keywords: Infantile Neuroaxonal Dystrophy ; Electron Microscopy ; Striated Muscle ; Membranous-Tubular Structures ; Filamentous Structures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This paper deals with the first ultrastructural study of muscle fiber in a child affected by infantile neuroaxonal dystrophy or Seitelberger's disease. In a first step, diagnosis was performed by light and electron microscopy in biopsy and autopsy findings in central and peripheral nervous system. Muscle fiber and axonal changes are very similar. The ultrastructure findings in muscle fiber are as follows: 1. neural atrophy, 2. overproduction of membrano-tubular structures related to sarcoplasmic reticulum hyperplasia, 3. filamentous aggregates by presumed overproduction of myofilaments, 4. overproduction of abnormal mitochondria. These changes, already described in various muscular diseases, are not specific; they seem related to an abnormal muscle fiber reaction in close association to dystrophic axonal endings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688446
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    The electron microscopic study of the appendix as early diagnostic means in Batten-Spielmeyer-Vogt disease (1972)
    Springer
    Acta neuropathologica 21 (1972), S. 169-175 
    Details
    ISSN: 1432-0533
    Keywords: Batten's Disease ; Electron Microscopy ; Appendix ; Curvilinear Inclusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The electron microscopic findings in the appendix of a five-year-old child suffering from Batten's disease are presented. They revealed accumulations of curviform densities in smooth muscle cells, nerve cells and Schwann cells of the myenteric plexus of Auerbach. Typical lipofuscin pigment was not observed. The presence of transitional forms, however, suggesting progressive transformation of the inclusions into lipofuscin-like granules, is briefly discussed. It is proposed that, during life, electron microscopy of the appendix might be useful for the diagnosis or more specific classification of a form of storage disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687571
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    La dystrophie neuroaxonale infantile ou maladie de Seitelberger (1970)
    Springer
    Acta neuropathologica 15 (1970), S. 327-350 
    Details
    ISSN: 1432-0533
    Keywords: Neuroaxonal Dystrophy Infantile ; Electron Microscopy ; Spheroids ; Smooth Endoplasmic Reticulum ; Mitochondria ; Seitelberger's Disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs rapportent 2 cas de DNAI.Le tableau clinique, d'évolution mortelle en 2 ans, associe un arrêt du développement psycho-moteur, des signes pyramidaux et extrapyramidaux, un nystagmus pendulaire avec atrophie optique. L'étude en microscopie optique définit:—les aspects morphologiques, la nature glycolipoprotéique et la répartition topographique des sphéroïdes, électivement disposés dans les structures médullaires, bulbo-protubérantielles et cérébelleuses, phylogénétiquement les plus anciennes, —l'atrophie du cortex cérébelleux, —la surcharge soudanophile avec état dysmyélinique du pallidum, —la dégénérescence des voies afférentes et efférentes des fibres longues de la moelle, du tronc cérébral et des voies optiques.L'étude en microscopie électronique précise la structure des sphéroïdes composés d'amas membrano-tubulaires et cisternaux, des corps denses amorphes ou lamellés, multigranuleux, pseudo-cristallins ou multivésiculaires et de mitochondries pathologiques. La formation de ce matériel est liée à l'hyperplasie du réticulum endoplasmique lisse et à l'accumulation de mitochondries anormales dans les péricaryons neuronaux, les prolongements dendro-axonaux, les culs de sacs synaptiques. Les auteurs rapprochent leurs constatations de faits semblables observés en pathologie humaine et expérimentale.
    Notes: Summary Two cases of INAD are reported. Clinical features with fatal issue within 2 years, are characterized by psychomotor retardation, pyramidal and extrapyramidal signs, pendular nystagmus with bilateral atrophia of optic discs.Light microscopy shows:—the morphology of spheroids, their glycolipoproteid component and their elective distribution in medulla, brain-stem and cerebellum, phylogenetically the oldest parts of the CNS—a cerebellar cortical atrophia—sudanophilic fatty deposits associated to status dysmyelinatus of pallidum—a degeneration of pyramidal, spinocerebellar tracts and optic pathways.Electron microscopy in the two cortical biopsies allows to specify the internal structure of spheroids made of membrano-tubular and interconnected aggregates, amorphous and lamellar electron-dense bodies, multigranular bodies, cristalline-like inclusions, multivesicular bodies and involved mitochondria. That complex material represents an overproduction of smooth endoplasmic reticulum and abnormal mitochondria located in neuronal perikarya, axons, dendrites and enlarged synaptic bulbs. These pathological findings are compared to those already described in human and experimental cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684731
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    Paper (German National Licenses)
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