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Cholesterol metabolism in ExHC (exogenous hypercholesterolemic) rats

Imaizumi, K. ; Nagatomi, A. ; Sato, M. ; [et al.]

Amsterdam : Elsevier

Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism 1123 (1992), S. 101-109

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ISSN: 0005-2760

Keywords: (ExHC rat) ; (Hepatocyte) ; Bile acid ; Hypercholesterolemia ; Lipoprotein uptaken ; β-Very-low-density lipoprotein

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Medicine , Physics

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2760(92)90176-V

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Secretion of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 by Meningiomas Detected by Cell Immunoblot Analysis (1999)

Mizoue, T. ; Kawamoto, H. ; Arita, K. ; [et al.]

Springer

Acta neurochirurgica 141 (1999), S. 481-486

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ISSN: 0942-0940

Keywords: Keywords: Meningioma; matrix metalloproteinase-9; tissue inhibitor of metalloproteinase-1; cell immunoblot.

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary To identify features of meningiomas that infiltrate dura mater, and to examine the role Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion in meningiomas, a cell immunoblot assay study was performed in 20 meningiomas. MMP-9 secretion was detected in 20 (100%) meningiomas and was independent of histological features. TIMP-1 secretion was detected in 8 (40%) meningiomas. For a cell immunoblot volume which included approximately 1350 cells, there were 50.4±49.4 dots which showed immunoreactivity to MMP-9 and 2.0±4.2 which showed immunoreactivity to TIMP-1. The number of dots that showed immunoreactivity to MMP-9 was not significantly different between tumours with atypical and benign histological features. TIMP-1 secretion was found in only 8 (40%) specimens and the percentage of TIMP-1 secreting cells was significantly lower than that of MMP-9 secretion. Thus, we propose that meningiomas classified histologically as both atypical and benign have the potential to infiltrate dura mater.