ISSN:
0942-0940
Keywords:
Keywords: Meningioma; matrix metalloproteinase-9; tissue inhibitor of metalloproteinase-1; cell immunoblot.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary To identify features of meningiomas that infiltrate dura mater, and to examine the role Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion in meningiomas, a cell immunoblot assay study was performed in 20 meningiomas. MMP-9 secretion was detected in 20 (100%) meningiomas and was independent of histological features. TIMP-1 secretion was detected in 8 (40%) meningiomas. For a cell immunoblot volume which included approximately 1350 cells, there were 50.4±49.4 dots which showed immunoreactivity to MMP-9 and 2.0±4.2 which showed immunoreactivity to TIMP-1. The number of dots that showed immunoreactivity to MMP-9 was not significantly different between tumours with atypical and benign histological features. TIMP-1 secretion was found in only 8 (40%) specimens and the percentage of TIMP-1 secreting cells was significantly lower than that of MMP-9 secretion. Thus, we propose that meningiomas classified histologically as both atypical and benign have the potential to infiltrate dura mater.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s007010050328
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