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  • Articles: DFG German National Licenses  (3)
  • Endogenous depression  (2)
  • Abscisic acid  (1)
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  • Articles: DFG German National Licenses  (3)
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Years
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 232 (1982), S. 299-304 
    ISSN: 1433-8491
    Keywords: Serum glutamate ; Endogenous depression ; Neurotic depression ; Antidepressants ; Serum-Glutamat ; endogene Depression ; neurotische Depression ; Antidepressiva
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Serum-Glutamatgehalt wurde bei endogen depressiven, neurotisch depressiven, schizophrenen und schizoaffektiven Patienten sowie gesunden Kontrollpersonen bestimmt. Hierbei zeigte sich, daß die Serumglutamatspiegel bei endogen und neurotisch Depressiven signifikant höher waren als bei den anderen Gruppen. Zwischen schizophrenen und schizoaffektiven Patienten sowie Kontrollen zeigten sich dagegen keine signifikanten Unterschiede. Die weitere Analyse der Daten erbrachte die Hypothese, daß die erhöhten Serum-Glutamat-Konzentrationen bei endogen und neurotisch Depressiven eine Folge der antidepressiven Medikation sind. Diese Ergebnisse werden im Hinblick auf die Wirkung der Antidepressiva auf das Serum-Glutamat bei affektiven Störungen diskutiert.
    Notes: Summary Glutamate concentration was determined in serum from endogenous and neurotic depressive patients, in persons with schizophrenia or schizoaffective disorder, and in normal subjects. The mean serum glutamate level in the endogenous and neurotic depressive patients was found to be significantly higher than in any of the other groups. No other statistically significant differences were found. Statistical analysis revealed that the elevated serum glutamate concentration in the endogenous and neurotic depressive patients was probably caused by medication. These results are discussed in view of the effect of antidepressants upon the serum glutamate in the affective disorders.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 231 (1981), S. 35-39 
    ISSN: 1433-8491
    Keywords: Total tryptophan ; Free tryptophan ; Endogenous depression ; Neurotic depression ; Gesamt- und freies Tryptophan ; Endogene Depression ; Neurotische Depression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Gesamt- und freies Tryptophan wurde im Plasma von 34 endogen Depressiven, 20 neurotisch Depressiven und 25 gesunden Kontrollpersonen bestimmt. Während beim Gesamttryptophan kein Unterschied zwischen den drei Gruppen festgestellt werden konnte, war das freie Tryptophan bei endogen Depressiven und neurotisch Depressiven signifikant erniedrigt. Zwischen endogen und neurotisch Depressiven fand sich kein Unterschied.
    Notes: Summary The levels of total and free tryptophan were determined in the plasma of 34 endogenous depressives, 20 neurotic depressives and 25 healthy volunteers. Whilst the levels of total tryptophan were not different in the three groups, the level of free tryptophan was reduced in both endogenous and neurotic depressives. No difference could be found between endogenous and neurotic depressives.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1617-4623
    Keywords: Key words Protein phosphorylation ; Osmotic stress Serine protein kinase ; Abscisic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Two soybean cDNA clones, SPK-3 and SPK-4, encoding putative protein kinases were isolated and characterized. Both cDNAs encoded approximately 40-kDa serine/threonine kinases with unusual stretches of acidic amino acids in their carboxy-terminal regions, which are highly homologous to PKABA1 from wheat and ASKs from Arabidopsis. These kinases are encoded by one- or two-copy genes in the soybean genome. Notably, SPK-3 and -4 showed different patterns of expression in various soybean tissues. SPK-3 is highly expressed in dividing and elongating tissues of young seedlings but relatively weakly in tissues of mature plants. In contrast, SPK-4 showed relatively high and constitutive expression in all the tissues examined except for leaf tissues of mature plants. Although various stressors, such as dehydration and high salinity, increased the expression of both genes, the induction kinetics were different. The two genes also differed in their response to abscisic acid (ABA). SPK-3 was induced but SPK-4 was not affected by exogenously supplied abscisic acid. In accordance with these expression data analysis of the activity of a chimeric SPK-3 promoter::β-glucuronidase (GUS) reporter gene by transient expression in tobacco leaves confirmed the inducibility of SPK-3 by salt and ABA. Polyclonal antibodies raised against a recombinant SPK-4 protein produced in Escherichia coli specifically recognized both recombinant SPK-3 and -4 proteins. Kinase assays using affinity-purified SPK-4/antibody complexes with crude soybean extracts as substrate identified specific phosphorylation of two 41 and 170 kDa soybean proteins that were phosphorylated on serine residues. Taken together, our results suggest that SPK-3, and/or SPK-4 are functional serine protein kinase(s). Furthermore, SPK-3 and -4 may play different roles in the transduction of various environmental stresses.
    Type of Medium: Electronic Resource
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