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  • Articles: DFG German National Licenses  (2)
  • Aerobic Ischemia  (1)
  • Assessment  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Schmerz 14 (2000), S. 302-308 
    ISSN: 1432-2129
    Keywords: Schlüsselwörter Schmerzmessung ; Diagnostik ; Instrumente ; Neugeborene ; Kinder ; Keywords Pain ; Measurement ; Assessment ; Instruments ; Neonates ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background. The assessment and measurement of pain is essential in the implementation and control of pain relieving strategies. The measurement of pain in infants and children should be based on the consideration of age, cognitive level, psychological status, intercurrent diseases and the social context in order to register the child's individual situation and to avoid misinterpretation. Diagnosis. In the preverbal infant, behavioral and physiological cues have to be interpreted by the caregivers. For the assessment of pain in children of four and older who have at least a basic understanding of the pain concept self assessment methods (as rating scales, specific pain interviews, diaries and questionnaires) can be used. In any case the instruments used should be age appropriate. The instruments used for the different age groups are presented with comments on quality and clinical applicability.
    Notes: Zusammenfassung Hintergrund. Voraussetzung zur Durchführung und Kontrolle einer adäquaten und effektiven Schmerztherapie sind die Erfassung und Quantifizierung des Schmerzes in seinen verschiedenen Dimensionen. Bei der Diagnostik des Schmerzes im Kindesalter müssen Alter, kognitiver Entwicklungsstand, psychologischer Status, interkurrierende Erkrankungen und der soziale Kontext berücksichtigt werden, um das Kind in seiner individuellen Situation erfassen zu können und Fehleinschätzungen zu vermeiden. Schmerzdiagnostik im Kindesalter. Im präverbalen Alter werden die physiologischen und verhaltensbezogenen Schmerzäußerungen von Neugeborenen, Säuglingen und Kleinkindern durch eine Fremdbeurteilung erfasst. Bei Kindern ab etwa 4 Jahren, die über ein einfaches Verständnis von Schmerz verfügen, sind Verfahren der Selbsteinschätzung wie einfache Ratingskalen, spezifische Schmerzinterviews, Tagebücher und Fragebögen die primär einzusetzenden Instrumente. In jedem Fall sollten die Instrumente altersgerecht gestaltet sein. Für die verschiedenen Altersgruppen werden Instrumente der Schmerzerfassung mit qualitativen Hinweisen auf deren Güte und klinische Anwendbarkeit vorgestellt.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2013
    Keywords: Renal Metabolism ; Renal Preservation ; Anaerobic Ischemia ; Aerobic Ischemia ; Renal O2-Persufflation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The changes in the status of the adenylic acid-creatine phosphate system and in glycogen, glucose, and lactate were investigated in canine kidneys during preservation in anaerobic and aerobic ischemia at normo- and hypothermia. For anaerobic ischemia, the kidneys were stored without additional measures; for aerobic ischemia, the ischemic kidneys were persufflated with gaseous O2 or gas mixtures containing O2 via the renal artery or vein (orthograde and retrograde aerobic ischemia respectively). Prior to preservation, the kidneys were flushed with cell-free perfusates. Changes in the metabolic status characteristic of anaerobic ischemia were a decrease in the tissue levels of ATP, creatine phosphate, glycogen, glucose, and the sum of adenine nucleotides, a transitory increase in ADP and AMP, and an increase in the tissue level of lactate. Hypothermia caused a retardation of the anaerobic alterations; the loss of ATP was slowed down by factors of 2 and 9.5 when the temperatures were lowered from 37° to 26° and 6°C, respectively. In aerobic ischemia with orthograde and retrograde persufflation of 100% O2 (persufflation pressure = PP 60 and 30 mm Hg), deviations from a regular metabolic status developed very slowly. While the ATP-level decreased to 50% of the control value within scarcely 30 min of anaerobic ischemia at 6°C, it was almost 48 h before a similar loss of ATP occurred during orthograde aerobic ischemia at 6°C. Reduction of O2 in the persufflation gas to 40 and 21 vol-% resulted in less adequate preservation of the metabolic status. Increasing PP to 100 mm Hg for orthograde persufflation had no effect. An increase in PP to 60 mm Hg for retrograde persufflation resulted in a further delay in the metabolic deterioration. The long-term preservation of a regular metabolic status or the slow deviation of the metabolic pattern from the normal range during ischemia with O2-persufflation indicates a significantly smaller energy deficit than during storage in anaerobic ischemia. It must be attributed to a sufficient aerobiosis in the aerobically ischemic kidney, during which organogenic substrates brought in by the initial perfusion are utilized.
    Type of Medium: Electronic Resource
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