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  • Articles: DFG German National Licenses  (4)
  • Oxidative stress  (2)
  • Anaerobic threshold  (1)
  • Exercise  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Short-term exercise training improves diaphragm antioxidant capacity and endurance (2000)
    Springer
    European journal of applied physiology 81 (2000), S. 67-74 
    Details
    ISSN: 1439-6327
    Keywords: Key words Diaphragm ; Oxidative stress ; Fatigue ; Lipid peroxidation ; Antioxidants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract These experiments tested the hypothesis that short-term endurance exercise training would rapidly improve (within 5 days) the diaphragm oxidative/antioxidant capacity and protect the diaphragm against contraction-induced oxidative stress. To test this postulate, male Sprague-Dawley rats (6 weeks old) ran on a motorized treadmill for 5 consecutive days (40–60 min · day−1) at approximately 65% maximal oxygen uptake. Costal diaphragm strips were excised from both sedentary control (CON, n=14) and trained (TR, n=13) animals 24 h after the last exercise session, for measurement of in vitro contraction properties and selected biochemical parameters of oxidative/antioxidant capacity. Training did not alter diaphragm force-frequency characteristics over a full range of submaximal and maximal stimulation frequencies (P 〉 0.05). In contrast, training improved diaphragm resistance to fatigue as contraction forces were better-maintained by the diaphragms of the TR animals during a submaximal 60-min fatigue protocol (P 〈 0.05). Following the fatigue protocol, diaphragm strips from the TR animals contained 30% lower concentrations of lipid hydroperoxides compared to CON (P 〈 0.05). Biochemical analysis revealed that exercise training increased diaphragm oxidative and antioxidant capacity (citrate synthase activity +18%, catalase activity +24%, total superoxide dismutase activity +20%, glutathione concentration +10%) (P 〈 0.05). These data indicate that short-term exercise training can rapidly elevate oxidative capacity as well as enzymatic and non-enzymatic antioxidant defenses in the diaphragm. Furthermore, this up-regulation in antioxidant defenses would be accompanied by a reduction in contraction-induced lipid peroxidation and an increased fatigue resistance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00013799
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Incidence of exercise induced hypoxemia in elite endurance athletes at sea level (1988)
    Springer
    European journal of applied physiology 58 (1988), S. 298-302 
    Details
    ISSN: 1439-6327
    Keywords: Exercise ; Induced hypoxemia ; Incremental exercise ; Trained athletes ; Arterial oxyhemoglobin saturation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent evidence suggests that exercise-induced hypoxemia (EIH) may occur in healthy trained endurance athletes. However, at present, no data exist to describe the regularity of EIH in athletes or non-athletes. Therefore, the purpose of the present investigation was to determine the incidence of EIH during exercise in healthy subjects varying in physical fitness. Subjects (N=68) performed an incremental cycle ergometer test to volitional fatigue with percent arterial oxyhemoglobin saturation (%SaO2) measured min-by-min. For the purpose of data analysis subjects were divided into three groups according to their level of physical training: 1) untrained (N=16), 2) moderately trained (N=27), and 3) elite highly trained endurance athletes (N=25). EIH was defined as a %SaO2 of ≤91% during exercise. EIH did not occur in any of the untrained subjects or the moderately trained subjects. However, EIH occurred in 52% of the highly trained endurance athletes tested and was highly reproducible (r=0.95; P〈0.05). These findings further confirm the existence of EIH in healthy highly trained endurance athletes and suggests a rather high incidence of EIH in this healthy population. Hence, it is important that the clinician or physiologist performing exercise testing in elite endurance athletes recognize that EIH can and does occur in the elite endurance athlete in the absence of lung disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417266
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Exercise training protects against contraction-induced lipid peroxidation in the diaphragm (1999)
    Springer
    European journal of applied physiology 79 (1999), S. 268-273 
    Details
    ISSN: 1439-6327
    Keywords: Key words Fatigue ; Antioxidant enzymes ; Non-protein thiols ; Lipid peroxidation ; Oxidative stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Endurance exercise training promotes a small but significant increase in antioxidant enzyme activity in the costal diaphragm (DIA) of rodents. It is unclear if these training-induced improvements in muscle antioxidant capacity are large enough to reduce oxidative stress during prolonged contractile activity. To test the hypothesis that training-related increases in DIA antioxidant capacity reduces contraction-induced lipid peroxidation, we exercise trained adult female Sprague-Dawley (n = 7) rats on a motor-driven treadmill for 12 weeks at ≈ 75% maximal O2 consumption (90 min/day). Control animals (n = 8) remained sedentary during the same 12-week period. After training, DIA strips from animals in both experimental groups were excised and subjected to an in vitro fatigue contractile protocol in which the muscle was stimulated for 60 min at a frequency of 30 Hz, every 2 s, with a train duration of 330 m. Compared to the controls, endurance training resulted in an increase (P 〈 0.05) in diaphragmatic non-protein thiols and in the activity of the antioxidant enzyme superoxide dismutase. Following the contractile protocol, lipid peroxidation was significantly lower (P 〈 0.05) in the trained DIA compared to the controls. These data support the hypothesis that endurance exercise training-induced increases in DIA antioxidant capacity protect the muscle against contractile-related oxidative stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004210050505
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Precision of ventilatory and gas exchange alterations as a predictor of the anaerobic threshold (1984)
    Springer
    European journal of applied physiology 52 (1984), S. 173-177 
    Details
    ISSN: 1439-6327
    Keywords: Anaerobic threshold ; Ventilatory threshold ; Exercise ventilation ; Gas exchange ; Blood lactate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Anaerobic threshold has been defined as the oxygen uptake ( $$\dot V_{{\text{O}}_{\text{2}} }$$ ) at which blood lactate (La) begins to rise systematically during graded exercise (Davis et al. 1982). It has become common practice in the literature to estimate the anaerobic threshold by using ventilatory and/or gas exchange alterations. However, confusion exists as to the validity of this practice. The purpose of this study was to examine the precision with which ventilatory and gas exchange techniques for determining anaerobic threshold predicted the anaerobic threshold resolved by La criteria. The anaerobic threshold was chosen using three criteria: (1) systematic increase in blood La (ATLa), (2) systematic increase in ventilatory equivalent for O2 with no change in the ventilatory equivalent for CO2 ( $${\text{AT}}_{\dot V_{\text{E}} } /\dot V_{{\text{O}}_{\text{2}} }$$ ), and (3) non-linear increase in expired ventilation graphed as a function of $$\dot V_{{\text{O}}_{\text{2}} }$$ ( $${\text{AT}}_{\dot V_{\text{E}} }$$ ). Thirteen trained male subjects performed an incremental cycle ergometer test to exhaustion in which the load was increased by 30 W every 3 minutes. Ventilation, gas exchange measures, and blood samples for La analysis were obtained every 3rd min throughout the test. In five of the thirteen subjects tested the anaerobic threshold determined by ventilatory and gas exchange alterations did not occur at the same $$\dot V_{{\text{O}}_{\text{2}} }$$ as the ATLa. The highest correlation between a gas exchange anaerobic threshold and ATLa was found for $${\text{AT}}_{\dot V_{\text{E}} } /\dot V_{{\text{O}}_{\text{2}} }$$ and was r=0.63 (P〈0.05). These data provide evidence that the ATLa and $${\text{AT}}_{\dot V_{\text{E}} }$$ do not always occur simultaneously and suggest limitations in using ventilatory or gas exchange measures to estimate the ATla.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433388
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    Paper (German National Licenses)
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