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  • Articles: DFG German National Licenses  (2)
  • Androgen receptor  (1)
  • Molecular markers  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Decrease in androgen binding and effect of androgen treatment in a case of X-linked bulbospinal neuronopathy (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 892-897 
    Details
    ISSN: 1432-1440
    Keywords: X-Linked recessive bulbospinal neuronopathy ; Spinal muscular atrophy ; Motoneuron disease ; Androgen receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract X-linked recessive bulbospinal neuronopathy is a motoneuron disorder to be distinguished from amyotrophic lateral sclerosis. Effective treatment is not known. Patients with X-linked recessive bulbospinal neuronopathy may show gynecomastia and testicular atrophy, and a mutation in the androgen receptor gene has been found associated with the disease. Intermediate steps leading from the androgen receptor abnormality to the clinical syndrome have not yet been elucidated. Therefore, binding of androgen ([3H]dihydrotestosterone) to its specific receptor by genital skin fibroblasts cultured from a patient with X-linked recessive bulbospinal neuronopathy and confirmed androgen receptor mutation was studied. Markedly decreased binding capacity was found. We treated the patient for 6 months with nandrolone-decanoate. No effect on his neuromuscular status was observed during 2 years of follow-up.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190748
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A genetic map of Asparagus officinalis based on integrated RFLP, RAPD and AFLP molecular markers (1998)
    Springer
    Theoretical and applied genetics 97 (1998), S. 1083-1089 
    Details
    ISSN: 1432-2242
    Keywords: Key words Asparagus ; Dioecious species ; Genetic map ; Molecular markers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  An integrated genetic map of the dioecious species Asparagus officinalis L. has been constructed on the basis of RFLP, RAPD, AFLP and isoenzyme markers. The segregation analysis of the polymorphic markers was carried out on the progeny of five different crosses between male and female doubled-haploid clones generated by anther culture. A total of 274 markers have been organized to ten linkage groups spanning 721.4 cM. Since the haploid chromosome number of asparagus is ten, the established linkage groups probably represent the different chromosomes; however, the only group associated with a specific chromosome is the one which includes sex, whose determinant genes have been located on chromosome 5. A total of 33 molecular markers (13 RFLPs, 18 AFLPs, 2 RAPDs and 1 isoenzyme) have been located on this chromosome. The closest marker to the sex determinant is the AFLP SV marker at 3.2 cM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050995
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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