ISSN:
1432-1440
Keywords:
Atrial fibrillation
;
Atrial flutter
;
Electrocardiography
;
Electrophysiology
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Sixteen patients were investigated by means of programmed atrial stimulation at two different driving rates: 100 and 120/min. All patients had an increased atrial vulnerability at both driving rates. After intravenous flecainide application (1 mg/kg body weight as a bolus followed by the same amount given by infusion over a period of 20 min) the increased vulnerability was abolished in 11 and 9 patients respectively. In the remaining patients the rate of induced atrial tachyarrhythmia decreased. These findings correlate with a significant prolongation of the effective refractory period of the right atrium and a significant shortening of the relative refractory period of the right atrium. It is concluded that flecainide may be effective in the treatment of atrial arrhythmias in man.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01487339
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