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  • Articles: DFG German National Licenses  (3)
  • Centroblastic lymphoma  (2)
  • Erythroleukämie  (1)
  • Megakaryocyte  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Germinal center cell lymphomas: Prognostic significance of their histopathological differentiation (1981)
    Springer
    Annals of hematology 43 (1981), S. 193-200 
    Details
    ISSN: 1432-0584
    Keywords: Non-Hodgkin lymphoma ; Centrocytic lymphoma ; Centroblastic-centrocytic lymphoma ; Centroblastic lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Clinical data of 48 patients with centrocytic, 83 patients with centroblastic/centrocytic and 64 patients with centroblastic lymphoma who had entered a prospective multicenter study of the Kiel Lymphoma Study Group since October 1975 were compared. Advanced (stage IV) disease at time of diagnosis, predominantly due to bone marrow infiltration, was most frequent in centrocytic (69% of patients) and in centroblastic/centrocytic (51% of patients) lymphomas as compared to only 28% of patients with centroblastic lymphoma. High survival probability of patients with localized centrocytic and centroblastic/centrocytic lymphomas after radiotherapy, contrasting with a worse prognosis of corresponding patients with centroblastic lymphoma, is compatible with the classification of these lymphoma entities as neoplasias of low-grade malignancy. However, as shown by this prospective and previous retrospective trials overall survival probability of patients with advanced centrocytic lymphoma was inferior to that observed in corresponding patients with centroblastic/centrocytic lymphoma. These findings suggest the possibility that patients with advanced centrocytic lymphoma occupy an intermediate position between typical low-grade and typical high-grade malignant non-Hodgkin lymphomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00363889
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Clinical and prognostic heterogeneity of non-hodgkin lymphomas of high-grade malignancy (1981)
    Springer
    Annals of hematology 43 (1981), S. 201-211 
    Details
    ISSN: 1432-0584
    Keywords: Non-Hodgkin lymphoma ; High-grade malignancy ; Lymphoblastic lymphoma ; Immunoblastic lymphoma ; Centroblastic lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Comparison of clinical data of 64 patients with centroblastic lymphoma, 55 patients with immunoblastic lymphoma and 31 patients with lymphoblastic lymphoma not only confirmed the original assumption of high-grade malignancy as proposed by the concept of the Kiel classification but also demonstrated distinct clinical differences, particularly between lymphoblastic lymphoma and the two other entities. Rapid lymph node enlargement as well as steep fall of survival curves within the first year after diagnosis were common characteristics. Bimodal age distribution, predominance of males and early generalization of disease were typical features of lymphoblastic lymphoma; elderly patients and patients with the unclassified subtypes of lymphoblastic lymphoma exhibited the worst prognosis. Whereas patients with centroblastic and immunoblastic lymphomas showed similar distribution of age, sex and initial stage of disease, patients with immunoblastic lymphoma presented more frequently with a reduced performance status and showed a poorer response to radio- and chemotherapy resulting in a worse prognosis discernible after the first year of follow-up. Generalization during course of the disease was significantly more frequent in immunoblastic than in centroblastic lymphoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00363890
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Besonders kleine Megakaryocyten bei chronisch myeloischer Leukämie, akuter Leukämie und Erythroleukämie (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 649-650 
    Details
    ISSN: 1432-1440
    Keywords: Megakaryocyte ; chronic myelocytic leukemia ; acute leukemia ; erythroleukemia ; Megakaryocyt ; chronisch myeloische Leukämie ; akute Leukämie ; Erythroleukämie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In vereinzelten Fällen von chronisch myeloischer Leukämie, akuter Leukämie und Erythroleukämie wurden neben „Mikrokaryocyten“ noch kleinere Formen des megakaryocytären Systems unter 300µm2 im Knochenmark und teilweise im Blut gefunden. Mit Fortschreiten dieser Erkrankung nimmt die Anzahl dieser Zellen zu. Dem morphologischen Erscheinungsbild nach kann es sich um Degenerationsformen der „Mikrokaryocyten“ bzw. kleiner Megakaryocyten handeln.
    Notes: Summary Fifteen of 63 cases of chronic myelocytic leukemia, acute leukemia and erythroleukemia showed, in addition to microkaryocytes, another abnormal type of megakaryocytes which were smaller than 300µm2 and of different morphological appearance. These extremely small megakaryocytes appeared in 4 of 15 patients in the peripheral blood. The relative frequency of the cells increased with the progress of the disease. The morphologic appearance suggests that these cells are degenerative forms of microkaryocytes or of small megakaryocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468802
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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