ISSN:
1432-2072
Keywords:
Key words Schizophrenia
;
Polydipsia
;
Drinking behavior
;
Mianserin
;
Clonidine
;
α2-Adrenoceptor
;
Adrenergic system
;
Body weight change
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Animal studies have suggested the involvement of the adrenergic system in drinking behavior. The present study investigated the involvement of the α2-adrenergic system in the polydipsia of patients with chronic schizophrenia by use of an α2 agonist and an antagonist. Four patients with schizophrenic disorders accompanied by intermittent hyponatremia and polydipsia were the subjects of, and completed, this study. Drinking behavior was assessed by calculating the percent of maximum weight gain [PMWG: (maximum diurnal weight – standard weight) × 100/standard weight]. Standard weight was defined as body weight after 8 h of water restriction. Clonidine (75, 150, and 225 mg/day) increased the PMWG in a dose-dependent manner in the four subjects. In contrast, in three of the subjects, mianserin (30, 60, and 90 mg/day) decreased PMWG, and the severe polydipsia disappeared almost completely. These findings indicate clearly that the α2-adrenergic system is involved in the drinking behavior of schizophrenic patients. Mianserin appears to be clinically useful in treating such patients with polydipsia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002130050254
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