ISSN:
1432-2072
Keywords:
Adenosine
;
Anxiety
;
Conflict behavior
;
Caffeine
;
Conditioned Suppression of Drinking (CSD)
;
Diazepam
;
l-PIA
;
NECA
;
Phenobarbital
;
Rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The present study examined the effects of the anxiolytics diazepam and phenobarbital, the A-1 adenosine agonist N6-R-phenylisopropyladenosine (l-PIA), and the A-2 adenosine agonist 5′-N-ethylcarboxamidoadenosine (NECA) on conflict behavior. Water-restricted rats were trained to drink from a tube that was electrified (0.5 mA intensity) on a FI-29s schedule, electrification being signaled by a tone. After 3 weeks of daily 10-min sessions, the animals accepted a stable number of shocks (punished responding) and consumed a consistent volume of water (unpunished responding) per session. Different doses ofl-PIA and NECA were then tested separately at weekly intervals. In addition, the effects of diazepam and phenobarbital were determined in animals pretreated with saline,l-PIA, or NECA. Neitherl-PIA (15–250 nmole/kg) nor NECA (2.5–20 nmole/kg) produced a significant anti-conflict effect when administered alone. Diazepam (1.25–10 mg/kg) or phenobarbital (10–40 mg/kg) administration to saline-pretreated rats resulted in a dose-dependent increase in punished responding (shocks received) with minimal effects on unpunished responding (water intake). Neitherl-PIA nor NECA pretreatment reliably altered the effects of diazepam on conflict behavior. Pretreatment withl-PIA, but not NECA, significantly reduced the anti-conflict effects of phenobarbital on conflict behavior. These data suggest that phenobarbital, but not diazepam, anti-conflict responses may involve interactions with A-1 adenosine receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02244091
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