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  • 1
    Electronic Resource
    Electronic Resource
    Potentiation of oxotremorine-induced hypothermia by alaproclate in PCA lesioned and non-lesioned rats (1989)
    Springer
    Psychopharmacology 97 (1989), S. 51-53 
    Details
    ISSN: 1432-2072
    Keywords: Thermoregulation ; Acetylcholine ; Muscarinic ; Serotonin ; Interaction ; Alaproclate ; Oxotremorine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Stimulation of muscarinic cholinergic receptors with the highly potent and selective receptor agonist oxotremorine produced hypothermia in rats. Alaproclate, a purported selective serotonergic reuptake inhibitor, potentiated this response. Destruction of central presynaptic serotonergic terminals with the potent cytotoxin p-chloroamphetamine (PCA) failed to attenuate the hypothermic response to oxotremorine in alaproclate-pretreated animals. These results could be taken to suggest that alaproclate may act, at least in part, via a non-serotonergic mechanism to potentiate the oxotremorine-induced hypothermic response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443412
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Enhancement of the memory of a previously learned aversive habit following pre-test administration of a variety of serotonergic antagonists in mice (1986)
    Springer
    Psychopharmacology 90 (1986), S. 24-27 
    Details
    ISSN: 1432-2072
    Keywords: Memory ; Retrieval ; Serotonin ; Receptor antagonists ; Inhibitory avoidance ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study examined the effects of pre-test administration of a number of serotonergic receptor antagonists on the retrieval of a previously learned aversive habit in the mouse. All of the receptor antagonists (pirenperone, ketanserin, mianserin, methysergide and metergoline) produced a dose-dependent increase in the latency to complete 5 s of drinking 48 h after training. This suppression of drinking could not be attributed to nonspecific effects of the drugs on behavior (e.g., illness, reduced thirst, or activity), as non-contingently trained mice failed to exhibit similar elevations in their test scores. These results are, therefore, further support for an important role for serotonin in the processes underlying learning and memory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00172866
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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