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  • Artikel: DFG Deutsche Nationallizenzen  (2)
  • Diagnostic imaging techniques  (1)
  • Findings  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Der Radiologe 37 (1997), S. 62-73 
    ISSN: 1432-2102
    Schlagwort(e): Schlüsselwörter Maligne Lymphome im Kindesalter ; Sonographie ; Indikationen ; Befunde ; Differentialdiagnose ; Key words Malignant lymphoma in childhood ; Ultrasound ; Indications ; Findings ; Differential diagnosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary The sonographic diagnosis of malignant lymphoma in childhood is described. Malignant lymphomas are sonographically relatively uniform: initial enlargement of the lymph nodes and organs involved and disturbance of normal echo texture by mainly hypoechoic lesions can be found. Generally, four sonographic patterns of infiltration are described: diffuse, small nodular, large nodular and bulky type. Secondary, tumor-related or inflammatory complications (e. g. dislocation or compression of vessels, thoracic inlet syndrome, venous thrombosis, ileus, urinary retention, abscess and effusion) can be sonographically evaluated. Response to therapy correlates with normalization of size and echo texture and recovery from tumor-related complications. Differential diagnosis with ultrasound is based on the topographic distribution and echo pattern of infiltration and, with certain restrictions, on the echogenicity of lesions and perfusion feasible with Doppler sonography. The primary diagnosis has to be established histologically.
    Notizen: Zusammenfassung Die Ultraschalldiagnostik maligner Lymphome im Kindesalter wird beschrieben. Lymphatische Sytemerkrankungen des Kindes sind sonographisch relativ einheitlich: initial finden sich Lymphknoten- und Organvergrößerungen, sowie Störung der normalen Echotextur meist in Form von hypoechogenen Läsionen. An den parenchymatösen Organen werden sonographisch im wesentlichen 4 Infiltrationsmuster beobachtet: diffus, klein-nodulär, groß-nodulär und der „Bulcky-Typ“. Sekundäre, tumor- oder entzündungsbedingte Komplikationen (Gefäßkompression, Einflußstauung, Thrombose, Ileus, Harntransportstörung, Abszesse, Ergüsse) sind sonographisch erfaßbar. Ein Therapieerfolg ist im Ultraschall an der Normalisierung der Lymphknoten- und Organgröße, der Rückkehr der normalen Organechogenität und der Rückbildung tumor- bzw. entzündungsbedingter Komplikationen erkennbar. Differentialdiagnostische Hinweise ergeben sich aus dem topographischen Verteilungsmuster und dem sonographischen Erscheinungsbild der Läsionen, sowie unter gewissem Vorbehalt anhand der Echogenität und der dopplersonographisch analysierbaren Durchblutungsverhätnisse. Die primäre Diagnose ist immer histologisch zu sichern.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Journal of cancer research and clinical oncology 119 (1993), S. 541-548 
    ISSN: 1432-1335
    Schlagwort(e): Hexadecylphosphocholine ; Diagnostic imaging techniques ; Soft-agar colony assay ; Fibroblasts ; DNA and RNA virus replication ; Cellular signal transduction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Alkylphosphocholines, and especially their main representative hexadecylphosphocholine (HPC), show high anticancer activity in methylnitrosourea(MNU)-induced autochthonous rat mammary carcinoma. The regression of MNU-induced rat mammary carcinoma during HPC treatment can be evaluated by computed tomography and sonography. This allows a noninvasive monitoring of therapy in vivo (tumor size, morphology, and blood supply). Both diagnostic modalities can show a rapid concentric decrease in tumor volume as well as the appearance of cystic, scarry, and necrotic areas in the tumor tissue as a result of HPC treatment. In addition, prior to, during and after therapy tumor perfusion can be assessed by color Doppler sonography in vivo. A more than 4-fold difference in HPC efficacy was observed when the colony growth of explanted MNU-induced mammary carcinoma cells was measured in the methylcellulose colony assay (IC50=180 νmol HPC/l) and the Hamburger Salmon colony assay (IC50=740 μmol HPC/l). IN the latter assay, growth of concomitantly seeded untransformed cells, especially of fibroblasts, is much lower than in the methylcellulose colony assay. We therefore assume that the antitumor efficacy of HPC against MNU-induced mammary carcinoma is enhanced by neighboring cells such as fibroblasts. Cell culture experiments with the three MNU-induced rat mammary carcinoma cell clones 1-C-2, 1-C-30, and 1-C-32 revealed IC50 values in the range of 50–70 μmol HPC/l. The volume of 1-C-2 cells increased up to 4-fold after 72 h of permanent exposure to 100 μmol HPC/l, a concentration that completely inhibited proliferation of tumor cell numbers without being cytotoxic. Nucleotide triphosphate levels dropped significantly after 24 h and were slowly restored in spite of continued exposure. After 72 h, they nearly reached those levels observed in plateau-phase cells. This suggests that HPC-induced growth inhibition has similarities with physiologically occurring growth arrest. Finally, replication of RNA viruses and DNA viruses was suppressed 30-fold and 7-fold, respectively, at low concentrations of HPC (12 μmol/l), which caused no or negligible growth inhibition in the virus-harboring cells, thus demonstrating specific antiviral activity of HPC. From these observations we conclude that HPC differs in many important aspects from conventional cytostatic agents and is certainly worth following-up in further investigations.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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