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  • Articles: DFG German National Licenses  (2)
  • Ganglioside GD3  (1)
  • germinoma  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Neurosurgical review 6 (1983), S. 51-55 
    ISSN: 1437-2320
    Keywords: Pineal tumours ; germinoma ; third ventricle tumours ; teratoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors encountered 95 cases of germinoma (two-cell pattern pinealoma) and teratoma involving the third ventricle and the pineal region from 1962 to 1980. Germinoma is radiosensitive. However, removal (extensive or total) of the tumour followed by postoperative irradiation showed better results than simple radiotherapy. In the recent 62 cases, 5-year and 10-year survival rates were 80.2% and 69.3% respectively (in children under 15 years, both were 86.9%). Teratoma is not radiosensitive and requires operation. For operating on a pineal germinoma, either an infratentorial supracerebellar approach or an occipital transtentorial approach is indicated. A teratoma, however, is sometimes too large for these approaches, when exposed, and therefore, the author prefers the transcallosal approach (for huge tumours the frontal transcallosal approach). Technical details will be reported and discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 109 (1991), S. 34-36 
    ISSN: 0942-0940
    Keywords: Ganglioside GD3 ; glioma ; shedding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The proportion of ganglioside GD3 increases in glioma tissue and GD3 content is correlated with malignancy of gliomas. This ganglioside can be detected in the sera of patients with glioma by thin-layer chromatographic analysis. Ganglioside GD3 was not detected in the sera of healthy donors and astrocytoma grade 2 patients. However, serum GD3 was detected in one of three astrocytoma grade 3 patients and seven of nine glioblastoma patients. These results show that shedding of GD3 increases in proportion to the degree of malignancy of gliomas. Nevertheless, all of the glioblastoma patients in this study were advanced cases. Considering the high reliability of radiological diagnostic techniques in the neurosurgical field, further study will be necessary to clarify the relationships between the GD3 level in serum and the properties of tumours.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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