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  • 1
    Electronic Resource
    Electronic Resource
    A membrane-bound, calcium-dependent protease in yeast α-cell cleaving on the carboxyl side of paired basic residues
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 144 (1987), S. 807-814 
    Details
    ISSN: 0006-291X
    Keywords: [abr] AMC; 7-amino-4-methylcoumarin ; [abr] Boc-; t-butyloxycarbonyl- ; [abr] DFP; diisopropyl fluorophosphate ; [abr] DTT; dithiothreitol ; [abr] EGTA; ethylene glycol bis(β-aminoethyl ether)-tetraacetic acid ; [abr] MCA; 4-methylcoumaryl-7-amide ; [abr] NEM; N-ethylmaleimide ; [abr] PMSF; phenylmethylsulfonyl fluoride ; [abr] STI; soybean trypsin inhibitor, Con A, concanavalin A ; [abr] TLCK; p-tosyl-L-lysine chloromethyl ketone ; [abr] TPCK; p-tosyl-L-phenylalanine chloromethyl ketone ; [abr] o-PT; o-phenanthroline ; [abr] pABA; p-aminobenzamidine ; [abr] pAPMSF; p-amidinophenylmethylsulfonyl fluoride ; [abr] pCMB; p-chloromercuribenzoate ; [abr] β-ME; 2-mercaptoethanol
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(87)80036-0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A membrane-bound, calcium-dependent protease in yeast α-cell cleaving on the carboxyl side of paired basic residues
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 144 (1987), S. 807-814 
    Details
    ISSN: 0006-291X
    Keywords: [abr] AMC; 7-amino-4-methylcoumarin ; [abr] Boc-; t-butyloxycarbonyl- ; [abr] DFP; diisopropyl fluorophosphate ; [abr] DTT; dithiothreitol ; [abr] EGTA; ethylene glycol bis(β-aminoethyl ether)-tetraacetic acid ; [abr] MCA; 4-methylcoumaryl-7-amide ; [abr] NEM; N-ethylmaleimide ; [abr] PMSF; phenylmethylsulfonyl fluoride ; [abr] STI; soybean trypsin inhibitor, Con A, concanavalin A ; [abr] TLCK; p-tosyl-L-lysine chloromethyl ketone ; [abr] TPCK; p-tosyl-L-phenylalanine chloromethyl ketone ; [abr] o-PT; o-phenanthroline ; [abr] pABA; p-aminobenzamidine ; [abr] pAPMSF; p-amidinophenylmethylsulfonyl fluoride ; [abr] pCMB; p-chloromercuribenzoate ; [abr] β-ME; 2-mercaptoethanol
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(87)80036-0
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Inhibition of mitogen-induced response of human peripheral blood mononuclear cells by bucillamine, a new antirheumatic sulfhydryl drug (1994)
    Springer
    Rheumatology international 13 (1994), S. 197-201 
    Details
    ISSN: 1437-160X
    Keywords: Bucillamine ; d-Penicillamine ; Hydrogen peroxide ; Cupric ion ; Rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mechanism of action of bucillamine, [N-(2-mercapto-2-methylpropionyl)-l-cysteine] (BC), a novel antirheumatic drug that is used in patients with rheumatoid arthritis (RA), was compared with that of d-penicillamine (DP). BC inhibited phytohemagglutinin (PHA)-induced DNA synthesis of peripheral blood mononuclear cells (PBMCs) in a dose-dependent manner, and this inhibition occurred both in the presence and absence of copper, whereas DP-induced inhibition required the presence of cupric ions. Significant inhibition of DNA synthesis was observed at a BC concentration of 10 μg/ml. The disulfide form of BC, but not DP disulfide, suppressed the proliferation of PBMCs. After preincubation of human peripheral blood T lymphocytes or Møs with BC or DP, these cells were combined and the overall PHA response was estimated. Inhibition of the PHA response was observed following pretreatment of either T lymphocytes or Møs with BC, whereas inhibition was attained only when T lymphocytes were pretreated with DP and copper. As sulfhydryl agents produce hydrogen peroxide in the presence of cupric ions, the effect of catalase on DP- and BC-induced inhibition of PBMC DNA synthesis was examined. Catalase partially reversed the BC-induced inhibition of DNA synthesis of PBMCs, and it restored the inhibition by DP and copper almost to the control level. These results suggest that BC suppresses the function of both T lymphocytes and Møs in the mitogen response of PBMCs, whereas the action of DP is targeted at T lymphocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390267
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Inhibition of neovascularization in vivo by gold compounds (1994)
    Springer
    Rheumatology international 14 (1994), S. 1-7 
    Details
    ISSN: 1437-160X
    Keywords: Angiogenesis ; Endothelial cell ; Gold Inflammation ; Rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract As mononuclear cell infiltration and growth of pannus critically depend on synovial neovascularization in rheumatoid arthritis (RA), inhibition of the synovial blood vessels would have the potential to reduce rheumatoid inflammation. In this investigation, we studied the effect of gold sodium thiomalate (GST) and auranofin (AUR) on neovascularization in vivo by using a micropocket technique. Both GST and AUR suppressed rabbit corneal neovascularization in a dose-dependent fashion. Significant inhibition was observed by 3 mg/kg GST and 1 mg/kg AUR injected intravenously every other day. These injections maintained serum gold concentrations at the level of 2–5 μg/ml and less than 2 μg/ml in GST-and AUR-injected rabbits, respectively. These are concentrations attained in the serum or synovium of rheumatoid patients treated by gold compounds. Similar inhibition was observed by both intramuscular administration of GST and oral administration of AUR. In contrast, no inhibition was observed when non-steroidal anti-inflammatory drugs (NSAIDs; 20 mg/kg acetylsalicylic acid, 10 mg/kg ibuprofen and 10 mg/kg indomethacin) were injected intravenously on a daily basis. These results suggested that gold compounds have an antiangiogenic effect in vivo. The inhibition of neovascularization by gold compounds suggested that they may suppress rheumatoid synovitis by reducing the number of small blood vessels required for mononuclear cell infiltration and synovial tissue proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00302664
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Quantitative GDOS analysis of oxide films on steels (1994)
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 22 (1994), S. 134-138 
    Details
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: A method for the quantitative analysis for oxide films on steels by means of glow discharge optical emission spectrometry (GDOS) was investigated. Effective optical emission yields for analysed elements were determined by measuring the emission intensities and sputtering rates of standard samples during discharging under constant conditions. The chemical composition in oxidized samples was obtained from the emission intensities and the effective emission yields, while the sputtered depth was calculated from the emission intensities and effective densities of elements. From measurements of the sputtering of magnetite the effective density for oxygen was estimated as 1820 kg m-3. It was shown that GDOS can be used to determine the quantitative composition and the thickness of the oxide layers on steels.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/sia.740220132
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Characterization of MoSi2 coatings obtained by atmospheric pressure and low-pressure plasma sprayingPaper presented at ECASIA 91 in Budapest, Hungary, 14-18 October 1991. (1992)
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 18 (1992), S. 589-593 
    Details
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The high-temperature oxidation resistance property of MoSi2 coatings is strongly influenced by the chemical composition, density and structure of the deposit. The aim of this work is to determine the role of the deposition process in the microchemistry and microstructure of the coating. In order to achieve this task, we compare MoSi2 produced by LPPS (low-pressure plasma spraying) and conventional APPS (atmospheric pressure plasma spraying) techniques with the aid of a complementary use of characterization methods such as SEM, EPMA (electron probe microanalysis), CMA (computer-aided microanalysis), GDOS (glow discharge optical spectroscopy) and XPS. From the overall results it is evident that the application of plasma spraying under low pressure considerably improves MoSi2 layers. They are characterized by a higher density, with fewer pores and discontinuities, and have a more uniform chemical composition and a better coating-substrate interface.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/sia.740180804
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Surface analytical study of the cause of mass gain of the kilogram prototype (1993)
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 20 (1993), S. 276-282 
    Details
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The International Prototype of the Kilogram, which is the only artificial material defining one of the fundamental constants, has been reported to gain mass as time elapses after it is cleaned. The surface of a Pt-Ir alloy that has been used for the newer Kilogram prototypes was analysed by XPS and thermal desorption spectroscopy (TDS) to investigate the cause of mass gain, its time dependence and the effect of the cleaning method. The main cause of the mass gain was found to be adsorption of carbon (in the form of hydrocarbons) and oxygen (as water) from the atmosphere. The amounts of the two contaminant elements were almost saturated 6 months after sample cleaning. Cleaning methods do not make a large difference to adsorption behaviour. Although surface iridium is slightly oxidized, this effect is negligibly small.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/sia.740200403
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    Paper (German National Licenses)
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