ISSN:
1432-2072
Schlagwort(e):
DRL
;
DRH
;
[Arg 8]-Vasopressin
;
Response rates
;
Response efficiency
;
Sex differences
;
Lever press
;
Rat
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Male and female Wistar rats were treated with different doses of vasopressin (0.05, 0.25, 1.25, 3.75 and 6.25 μg/kg) after responding had stabilized on either a differential reinforcement of low rate 15 s (DRL 15 s) or a differential reinforcement of high rate 0.75 s (DRH 0.75 s) schedule of reinforcement. Low to moderate doses of vasopressin did not affect response rates, response efficiency or the number of reinforcers obtained during vasopressin sessions on both the DRL and DRH schedules. Administration of 6.25 μg/kg vasopressin reduced low response rates and the number of reinforcers obtained during vasopressin sessions, but increased response efficiency. High response rates and response efficiency were reduced after administration of 3.75 and 6.25 μg/kg vasopressin, while the number of reinforcers obtained during vasopressin sessions was reduced at 6.25 μg/kg. Sex differences in the effects of vasopressin were not observed on either schedule.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00175192
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