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  • 1
    ISSN: 1432-2072
    Keywords: DRL ; DRH ; [Arg 8]-Vasopressin ; Response rates ; Response efficiency ; Sex differences ; Lever press ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Male and female Wistar rats were treated with different doses of vasopressin (0.05, 0.25, 1.25, 3.75 and 6.25 μg/kg) after responding had stabilized on either a differential reinforcement of low rate 15 s (DRL 15 s) or a differential reinforcement of high rate 0.75 s (DRH 0.75 s) schedule of reinforcement. Low to moderate doses of vasopressin did not affect response rates, response efficiency or the number of reinforcers obtained during vasopressin sessions on both the DRL and DRH schedules. Administration of 6.25 μg/kg vasopressin reduced low response rates and the number of reinforcers obtained during vasopressin sessions, but increased response efficiency. High response rates and response efficiency were reduced after administration of 3.75 and 6.25 μg/kg vasopressin, while the number of reinforcers obtained during vasopressin sessions was reduced at 6.25 μg/kg. Sex differences in the effects of vasopressin were not observed on either schedule.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2072
    Keywords: DRL ; DRH ; d-Amphetamine ; Response rate ; Rate-dependency ; Sex differences ; Lever press ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present experiments investigated sex differences in the effects of d-amphetamine on schedule-controlled behavior. Male and female Wistar rats were exposed to either a differential reinforcement of low rate 15 s schedule, or a differential reinforcement of high rate 0.75 s schedule and challenged with different doses of d-amphetamine (0.2, 0.4, 0.8, 1.6 and 3.2 mg/kg). d-Amphetamine in low to moderate doses increased low response rates. High doses of d-amphetamine decreased low and high response rates in both males and females. The response rate increasing effects of d-amphetamine on low baseline rates were significantly higher for females than for males. Sex differences for high baseline rates were not observed. The results of these experiments show not only that hormonal and neurochemical variables influence the effects of d-amphetamine administration on schedule-controlled behavior, but also that environmental contingencies maintaining the behavior can modify these effects.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-2800
    Keywords: sexuality ; mood ; androgens ; premenstrual complaints ; sex hormones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract The role of sex hormones in sexuality and mood across the menstrual cycle was investigated. Twenty-one normal healthy women were followed for one menstrual cycle. Blood samples were taken frequently, and analyzed for estradiol, progesterone, testosterone, androstenedione, dehydroepiandrosterone sulfate, cortisol, and sex hormone-binding globulin. A diary concerning sexual interest and behavior, and different moods, was completed daily. Although the sample was not large, a clear effect of menstrual cycle phase on levels of testosterone and the free testosterone index was demonstrated. In a preliminary screening interview, 11 of the 21 women had reported that they suffered from premenstrual complaints (PC), the other 10 had reported no complaints in the premenstrual phase (NPC). Significant differences between the two groups were established in estradiol and the estradiol–progesterone ratio, with the NPC group having higher levels of both endocrine parameters across different menstrual samples. Psychologically, a cycle effect on tension and sexual interest was demonstrated. The NPC group reported a peak in sexual interest in the premenstrual phase, whereas the PC group reported a peak in the ovulatory phase. There was a difference between the two groups in feelings of fatigue but not in other moods across the menstrual cycle. The study provides further evidence of the importance of androgen levels in women's sexuality and shows again that the relationship between menstrual cycle phase and sexuality is much clearer than between phase and mood.
    Type of Medium: Electronic Resource
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