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  • Articles: DFG German National Licenses  (13)
  • 1
    Electronic Resource
    Electronic Resource
    Postmortem MRI of the brain with neuropathological correlation (1995)
    Springer
    Neuroradiology 37 (1995), S. 343-349 
    Details
    ISSN: 1432-1920
    Keywords: Key words Magnetic resonance imaging (MRI) ; Postmortem examinations ; Brain tumours ; Correlative studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We prospectively correlated in vitro MRI of the brain with the neuropathological findings in patients with suspected intracranial disease. In vitro MRI was performed on 91 consecutive formalin-fixed whole-brain specimens. In 60 cases, the images were correlated with the neuropathological findings (number of lesions, lesion boundaries, spread of oedema and type of lesions). As compared with neuropathology, MRI showed an equal number of lesions in 50 cases, more in 5, and less in 5 specimens, resulting in a sensitivity of 83.3 %. The extent of perilesional oedema was better seen on in vitro MRI than on gross pathology. Microscopic extent of glial tumours was underestimated on both T2-weighted images and macroscopic examination. Neuropathology remains the reference study, since on in vitro MRI primary brain tumours, metastatic deposits and non-neoplastic space-occupying lesions cannot be differentiated. However, in our study MRI had a specificity of 76.6 %. MRI of postmortem specimens is sensitive to focal brain lesions, and can focus the attention of the neuropathologist to abnormal regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588007
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Postmortem MRI of the brain with neuropathological correlation (1995)
    Springer
    Neuroradiology 37 (1995), S. 343-349 
    Details
    ISSN: 1432-1920
    Keywords: Magnetic resonance imaging (MRI) ; Postmortem examinations ; Brain tumours ; Correlative studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We prospectively correlated in vitro MRI of the brain with the neuropathological findings in patients with suspected intracranial disease. In vitro MRI was performed on 91 consecutive formalinfixed whole-brain specimens. In 60 cases, the images were correlated with the neuropathological findings (number of lesions, lesion boundaries, spread of oedema and type of lesions). As compared with neuropathology, MRI showed an equal number of lesions in 50 cases, more in 5, and less in 5 specimens, resulting in a sensitivity of 83.3%. The extent of perilesional oedema was better seen on in vitro MRI than on gross pathology. Microscopic extent of glial tumours was underestimated on both T2-weighted images and macroscopic examination. Neuropathology remains the reference study, since on in vitro MRI primary brain tumours, metastatic deposits and non-neoplastic space-occupying lesions cannot be differentiated. However, in our study MRI had a specificity of 76.6%. MRI of postmortem specimens is sensitive to focal brain lesions, and can foucus the attention of the neuropathologist to abnormal regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588007
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Clinical usefulness of contrast-enhanced MP-RAGE of the brain (1996)
    Springer
    Neuroradiology 38 (1996), S. S14 
    Details
    ISSN: 1432-1920
    Keywords: Key words Brain ; Magnetic resonance imaging ; techniques ; Magnetic resonance imaging ; contrast enhancement ; Three-dimensional imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Our purpose was to evaluate the usefulness of a 3D T1-weighted gradient-echo sequence (MP-RAGE) in clinical practice. We prospectively examined 200 patients with a variety of neurological disorders and symptoms. We compared lesion conspicuity and contrast enhancement on MP-RAGE images with conventional gadolinium-enhanced spin-echo (SE) T1-weighted images. Both the original MP-RAGE data and the reformatted images were characterised by improved differentiation between grey and white matter. More lesions were found on the 3D series, in both patients with neoplastic and non-neoplastic disease. Contrast enhancement of small oedematous lesions affecting the white matter in demyelinating disease was less obvious. Multiplanar reformatting, which can be realised in any desired plane and surface rendering with sophisticated segmentation algorithms superbly displayed the underlying anatomical relationships between lesions and normal brain structures. Excellent spatial resolution, the absence of posterior fossa artefacts and equivalent contrast enhancement resulted in an increased number of space-occupying lesions being found on the MP-RAGE images. Thus contrast-enhanced MP-RAGE is an alternative to conventional SE imaging in the investigation of intracranial masses. Although the total number of lesions found in patients with demyelinating disease was significantly higher on MP-RAGE, demonstration of blood-brain-barrier breakdown in active lesions was less obvious.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050911
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    MRI after successful lumbar discectomy (1996)
    Springer
    Neuroradiology 38 (1996), S. S90 
    Details
    ISSN: 1432-1920
    Keywords: Key words Spine ; Intervertebral discs ; Magnetic resonance imaging ; Spinal surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Our aim was to establish the normal range of MRI findings after successful lumbar discectomy. We prospectively examined 34 consecutive patients with an excellent clinical outcome by MRI 6 weeks and 6 months after surgery. All examinations included sagittal and axial spin-echo (SE) T1-weighted images before and after intravenous gadolinium-DTPA and fast SE T2-weighted images. Contrast enhancement along the surgical tract was seen in all patients 6 weeks and 6 months after surgery. After 6 months minimal or no mass effect on the dural sac by epidural scar was seen. In 20 % of patients there was recurrent disc herniation, with mass effect. Enhancing nerve roots were seen in 20 % of patients 6 weeks postoperatively, and half of these were associated with recurrent disc herniation at the same side. None of these patients still showed nerve root enhancement 6 months after surgery. Postoperative MRI studies must be interpreted with great care since the features described in the failed back surgery syndrome are also found, to some extent, in asymptomatic postoperative patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050929
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Clinical usefulness of contrast-enhanced MP-RAGE of the brain (1996)
    Springer
    Neuroradiology 38 (1996), S. S14 
    Details
    ISSN: 1432-1920
    Keywords: Brain ; Magnetic resonance imaging, techniques ; Magnetic resonance imaging, contrast enhancement ; Three-dimensional imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Our purpose was to evaluate the usefulness of a 3D T1-weighted gradient-echo sequence (MP-RAGE) in clinical practice. We prospectively examined 200 patients with a variety of neurological disorders and symptoms. We compared lesion conspicuity and contrast enhancement on MP-RAGE images with conventional gadolinium-enhanced spin-echo (SE) T1-weighted images. Both the original MP-RAGE data and the reformatted images were characterised by improved differentiation between grey and white matter. More lesions were found on the 3D series, in both patients with neoplastic and nonneoplastic disease. Contrast enhancement of small oedematous lesions affecting the white matter in demyelinating disease was less obvious. Multiplanar reformatting, which can be realised in any desired plane and surface rendering with sophisticated segmentation algorithms superbly displayed the underlying anatomical relationships between lesions and normal brain structures. Excellent spatial resolution, the absence of posterior fossa artefacts and equivalent contrast enhancement resulted in an increased number of space-occupying lesions being found on the MPRAGE images. Thus contrast-enhanced MP-RAGE is an alternative to conventional SE imaging in the investigation of intracranial masses. Although the total number of lesions found in patients with demyelinating disease was significantly higher on MP-RAGE, demonstration of blood-brain-barrier breakdown in active lesions was less obvious.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02278112
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    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    MRI after successful lumbar discectomy (1996)
    Springer
    Neuroradiology 38 (1996), S. S90 
    Details
    ISSN: 1432-1920
    Keywords: Spine ; Intervertebral discs ; Magnetic resonance imaging ; Spinal surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Our aim was to establish the normal range of MRI findings after successful lumbar discectomy. We prospectively examined 34 consecutive patients with an excellent clinical outcome by MRI 6 weeks and 6 months after surgery. All examinations included sagittal and axial spin-echo (SE) T1-weighted images before and after intravenous gadolinium-DTPA and fast SE T2-weighted images. Contrast enhancement along the surgical tract was seen in all patients 6 weeks and 6 months after surgery. After 6 months minimal or no mass effect on the dural sac by epidural scar was seen. In 20% of patients there was recurrent disc herniation, with mass effect. Enhancing nerve roots were seen in 20% of patients 6 weeks postoperatively, and half of these were associated with recurrent disc herniation at the same side. None of these patients still showed nerve root enhancement 6 months after surgery. Postoperative MRI studies must be interpreted with great care since the features described in the failed back surgery syndrome are also found, to some extent, in asymptomatic postoperative patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02278130
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    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Cerebral ganglioglioma and neurofibromatosis type I (1991)
    Springer
    Neuroradiology 33 (1991), S. 357-359 
    Details
    ISSN: 1432-1920
    Keywords: Ganglioglioma ; Neurofibromatosis ; Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report the occurrence of a left frontal lobe ganglioglioma in a patient with neurofibromatosis type I (von Recklinghausen's disease) and conclude that the occurrence of a cerebral ganglioglioma in a patient with neurofibromatosis must probably be considered coincidental.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587825
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    The value of MRI in the diagnosis of postoperative spondylodiscitis (2000)
    Springer
    Neuroradiology 42 (2000), S. 580-585 
    Details
    ISSN: 1432-1920
    Keywords: Key words Spine ; surgery ; Infection ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated the role of MRI in the diagnosis of postoperative spondylodiscitis. Spondylodiscitis is a serious complication of surgery, and the diagnosis frequently depends on a combination of clinical, laboratory and imaging findings. We compared the MRI findings in six patients with biopsy- or surgery-proven spondylodiscitis with those in 38 asymptomatic postoperative patients. Contrast enhancement and signal changes in the intervertebral disc or the vertebral endplates are not specific for spondylodiscitis, being also seen in the asymptomatic patients. However, absence of Modic type 1 changes, of contrast enhancement of the disc or of enhancing paravertebral soft tissues suggests that the patient does not have spondylodiscitis. MRI appears more useful for exclusion than for confirmation of postoperative spondylodiscitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340000361
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Distribution and incidence of degenerative spine changes in patients with a lumbo-sacral transitional vertebra (1997)
    Springer
    European spine journal 6 (1997), S. 168-172 
    Details
    ISSN: 1432-0932
    Keywords: Transitional vertebrae ; Suprajacent degenerations ; Spine CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this prospective study was to determine the overall incidence and distribution of lumbo-sacral degenerative changes (i.e. disc protrusion or extrusion, facet degeneration, disc degeneration, nerve root canal stenosis and spinal stenosis) in patients with and without a lumbo-sacral transitional vertebra (LSTV). The study population consisted of 350 sequential patients with low back pain and/or sciatica, referred for medical imaging. In all cases CT scans of the lumbosacral region were obtained. In 53 subjects (15%) an LSTV was found. There was no difference in overall incidence of degenerative spine changes between the two groups. We did find, however, a different distribution pattern of degenerative changes between patients with and those without an LSTV Disc protrusion and/or extrusion occurred more often at the level suprajacent to the LSTV than at the same level in patients without LSTV (45.3% vs 30.3%). This was also the case for disc degeneration (52.8% vs 28%), facet degeneration (60.4% vs 42.6%) and nerve root canal stenosis (52.8% vs 27.9%). For spinal canal stenosis there was no statistically significant difference between the two categories. In conclusion, our findings indicate that an LSTV does not in itself constitute a risk factor for degenerative spine changes, but when degeneration occurs, it is more likely to be found at the disc level above the LSTV.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01301431
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of field strength on gadolinium enhancement in MR imaging (1994)
    Springer
    European radiology 4 (1994), S. 557-560 
    Details
    ISSN: 1432-1084
    Keywords: MR ; Contrast media ; Gadolinium ; Contrast enhancement ; Field strength
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This studv was designed to evaluate the influence of magnetic field strength on the relative enhancement effect (RE) of gadolinium (Gd)-chelates. Dilution series of two paramagnetic contrast agents (Gd-DTPA and Gd-DOTA) were examined in three commercially available MR systems. operating at different field strengths (02 T, 1. T, and 1.5 T). The RE was plotted against Gd concentration. The highest increases in signal intensity occurred with Gd concentrations of approximately L.0 mmol/L. No significant difference in RE was observed between MR systems ranging in field strength from 0.? T to 1.5 T. The RE of Gd-DTPA and Gd-DOTA was found to he equivalent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226829
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    Paper (German National Licenses)
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