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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 28 (1977), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Partly purified chromaffin granules were incubated in vitro with Ca2+ (with trace amounts of 45Ca2+) in concentrations ranging from 4 μm to 1 mm. After incubation the granules were washed with media containing EDTA and then subjected to density gradient centrifugation (1.3 to 2.0 m-sucrose solutions) in order to characterize the particles which had taken up 45Ca2+. By using marker enzymes and various inhibitors of Ca2+ uptake into such cell particles as mitochondria it was established that under the conditions of the experiments chromaffin granules took up Ca2+ from the incubation medium. To characterize this uptake a simplified density gradient procedure was tested and found to be suitable. The uptake of Ca2+ into chromaffin granules was strongly dependent on temperature. It was not activated by ATP. The uptake was linear up to 10 min. At high calcium concentrations (above 200 μm) the rate of uptake levelled off. The uptake at 37°C was 1 nmol Ca2+/mg protein/min at a Ca2+ concentration of 500 μm. Mg2+ had no influence on Ca2+ uptake, whereas Sr2+ (1 mm) inhibited it. The methods established in this study should prove useful for a further characterization of this Ca2+ uptake into chromaffin granules which is likely to represent a useful model for the Ca2+ uptake occurring in the intact gland.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 27 (1976), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 69 (1996), S. 2698-2700 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We compare the field screening behavior of quantum-confined Stark effect modulator structures where the GaInAsP/InP heterojunction is in the intrinsic (standard structure) or in the doped regions (modified structure) at working wavelengths of 1.55 and 1.3 μm. The modified structures are obtained by expanding the GaInAsP confinement layers into the p-doped and n-doped regions without changing the total intrinsic layer thickness. The effectiveness of the InP heterobarriers for the holes on the p-side and for the electrons on the n-side is thereby lowered. A significant reduction of field screening for the modified structures is achieved. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 11 (1981), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effectiveness of inhaled versus oral metaproterenol in preventing exercise-induced asthma (EIA) was studied.Inhaled metaproterenol given 10 min before the exercise significantly reduced the degree of EIA in a group of twenty-four patients, and in 75% of them completely prevented it. The mean percentage decrease in FEV1 was 6-5% with the inhaler and 30.1%, with placebo. When inhaled 1 hr before the exercise, metaproterenol was still better than placebo but its effectiveness was considerably lower. Metaproterenol tablets had a slight protective effect given I hr before, and none when administered 2 hr before exercise.There was no correlation between the protective effect against EIA and the bronchodilating effect obtained before exercise. Metaproterenol administered by metered-dose inhaler is a very effective prophylactic medication against clinically troublesome EIA, while metaproterenol tablets should not be recommended for this purpose.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 3 (1973), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect of an increased frequency of administration of sodium cromoglycate (SCG) was studied in twenty-four asthmatic children who had previously responded poorly to 3–4 capsules per day. Six out of seven children who were assessed clinically alone improved when their dose was raised to 6 capsules daily. When a diary score and bronchodilator consumption were recorded, the more frequent administration of SCG gave significantly better results in eleven of seventeen children. However, only five of the twelve children given peak flow meters to use twice daily at home showed objective improvement.At the beginning of the trial four children were on systemic corticosteroid treatment and two of them were weaned off while on the raised dosage of SCG. The other two were not improved and were treated with a corticosteroid aerosol, beclomethasone diproprionate (Becotide), as were two other SCG failures. There was no clear correlation between the duration of protection given by SCG on exercise testing and the clinical response in this trial.The fact that only four out of twenty-four children who previously did not respond satisfactorily to SCG eventually needed corticosteroids, suggests that the increased frequency of administration may reduce the proportion of children failing to respond to SCG.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Physics and Chemistry of Solids 20 (1961), S. 122-126 
    ISSN: 0022-3697
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Chemical Physics Letters 179 (1991), S. 114-118 
    ISSN: 0009-2614
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European food research and technology 67 (1934), S. 113-144 
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European food research and technology 70 (1935), S. 26-33 
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European food research and technology 71 (1936), S. 121-137 
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Zusammenfassung Die Konservierung von Tabakfabrikaten, um sie vor dem Muffigwerden und Verschimmeln sowie vor der Gärung (Kautabak) zu schützen, dürfte so alt sein wie die Tabakfabrikation selbst; namentlich gilt dies für den Kautabak, der sich früher einer viel weiter gehenden Verwendung erfreute als heute. Eine eingehende Bearbeitung hat das Problem der Tabakkonservierung (physikalisch und chemisch) bisher noch nicht erfahren. Die Versuche erstreckten sich nur auf die Konservierung mit chemischen Mitteln. Durch Umfrage in der Tabakindustrie wurden die hier gebräuchlichen Mittel festgestellt. Die Versuche bringen zunächst einen Vergleich der Konservierungsmittel auf einem Agar-Nährboden. Bei ihrer Prüfung auf Tabak (Tabakfabrikate zu Rauchzwecken) wurden Schnittbreite, Menge und Zusammensetzung der Soßierung, Beschaffenheit des Tabaks und Wassergehalt berücksichtigt. Aus der Bewertung der geprüften Konservierungsmittel für ihre Eignung zur Schimmelverhütung auf Rauchtabak ergibt sich die folgende abnehmende Reihenfolge hinsichtlich der wirksamen Zusatzmengen: Chinosol, Ester der p-Oxybenzoesäure und deren Natriumsalze (als Handelspräparate unter den Namen Solbrol, Nipagin, Nipasol usw. erhältlich), Benzoesäure, Natriumbenzoat. Die in der Reihenfolge nun folgenden Mittel, nämlich Salicylsäure, Natriumformiat und Borsäure halten wir infolge ihrer verhältnismäßig geringen konservierenden Wirkung auf Tabak für nicht geeignet. Andere Eigenschaften der Mittel, z. B. ihre praktische Verarbeitungsmöglichkeit und etwaige Beeinflussung des Tabaks, sind hierbei nicht berücksichtigt. Die Versuche sollen vorerst nur die Brauchbarkeit bestimmter chemischer Stoffe als Konservierungsmittel für Tabak zeigen; sie lassen dagegen die Frage der von den näheren Umständen abhängigen Notwendigkeit der Anwendung eines Konservierungsmittels bei den einzelnen Tabakerzeugnissen unberührt.
    Type of Medium: Electronic Resource
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