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  • 1
    Electronic Resource
    Electronic Resource
    The role of MRI in dementia (1999)
    Springer
    Italian journal of neurological sciences 20 (1999), S. S250 
    Details
    ISSN: 1126-5442
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neuroimaging techniques aimed at studying structural changes of the brain may provide useful information for the diagnosis and the clinical management of patients with dementia. Magnetic resonance imaging (MRI) may show abnormalities amenable to surgical treatment in a significant percentage of patients with cognitive impairment. MRI may also assist the differential diagnosis in dementia associated with metabolic or inflammatory diseases. MRI has the potential to detect focal signal abnormalities which may assist the clinical differentiation between Alzheimer's disease (AD) and vascular dementia (VaD). Severe temporal atrophy, hyperintensities involving the hippocampal or insular cortex, and gyral hypointense bands are more frequently noted in AD. Basal ganglionic/thalamic hyperintense foci, thromboembolic infarctions, confluent white matter and irregular periventricular hyperintensities are more common in VaD. The high sensitivity of MRI in detecting T2 hyperintense lesions and the low specificity off white matter lesions have resulted in a poor correlation between MRI findings and both neuropathological and clinical manifestations. In particular, MRI has disclosed a series of white matter focal changes in the elderly population, which are not necessarily associated with cognitive dysfunction. The recent advent of a new MRI method sensitive to the microstructural changes of white matter, the so-called diffusion tensor imaging, may be helpful in correlating clinical manifestations with white matter abnormalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100729970006
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  • 2
    Electronic Resource
    Electronic Resource
    Metastasis Along the Stereotactic Biopsy Trajectory in Glioblastoma Multiforme (1999)
    Springer
    Acta neurochirurgica 141 (1999), S. 1011-1012 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050410
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Supratentorial diffuse astrocytic tumours: proposal of an MRI classification (1997)
    Springer
    European radiology 7 (1997), S. 395-399 
    Details
    ISSN: 1432-1084
    Keywords: Key words: MRI ; Glioblastoma ; Astrocytoma ; Grading ; Classification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of this study was to obtain an MRI severity-related classification of diffuse astrocytic tumours able to integrate the histological data in the grading of such tumours. We studied presurgical MR images of 91 patients with a histological diagnosis of astrocytoma, anaplastic astrocytoma and glioblastoma. A score ranging from 1 to 3 was assigned by two independent readers to each of the following MR features: oedema, mass effect, contrast enhancement, borders, signal homogeneity, necrosis, haemorrhage and flow void. Statistical analysis showed significant differences in the mean MRI scores between the three histological grades. Contrast enhancement was found to be the best predictor of the histological grade followed by necrosis, signal homogeneity and border scores. This classification represents a simple and reproducible means of carefully evaluating some macroscopic characteristics of these tumours. It could be used to integrate histological data especially in cases in which tissue sampling defects may affect the validity of this examination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050173
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  • 4
    Electronic Resource
    Electronic Resource
    Hyperdense middle cerebral artery CT sign (1991)
    Springer
    Neuroradiology 33 (1991), S. 207-211 
    Details
    ISSN: 1432-1920
    Keywords: CT ; Cerebral infarction ; MCA ; Embolism ; Angiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The early CT finding of an hyperdensity of a portion of the middle cerebral artery Hyperdense Middle Cerebral Artery Sign (HMCAS), in patients with supratentorial stroke, is often indicative of an embolic occlusion. Aim of this study was to verify the incidence and reliability of the HMCAS and its possible correlation with early CT findings and with the extent of late brain damage. We studied 36 patients presenting with symptoms of stroke in the MCA territory, by means of CT and angiography performed respectively within 4 and 6 hours. Follow-up CT scans were then obtained after one week and three months from the ischemic event. The HMCAS was present in 50% of our patients and in this group it always correlated positively with the angiographic finding of occlusion. The same group presented a high incidence of erly CT hypodensity (88%). Finally the presence of HMCAS might be considered a negative prognostic sign for the development of extensive brain damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588219
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  • 5
    Electronic Resource
    Electronic Resource
    Correlation between MRI findings and long-term outcome in patients with severe brain trauma (2000)
    Springer
    Neuroradiology 42 (2000), S. 860-867 
    Details
    ISSN: 1432-1920
    Keywords: Key words Traumatic brain injury ; Magnetic resonance imaging ; Pulse sequences
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Our aim was to relate MRI findings in patients with severe traumatic brain injury (TBI) to clinical severity and long-term outcome. We studied 37 patients with severe TBI, who were submitted to clinical assessment for disability and cognition and to MRI 60–90 days after trauma. Clinical assessment was also performed 3, 6 and 12 months later. The number and volume of lesions in various cerebral structures were calculated semiautomatically from FLAIR and fast field-echo images. Possible correlations between total and regional lesion volume and clinical deficits were then investigated. The frontal and temporal lobes were most frequently involved. Total lesion volume on FLAIR images correlated significantly with clinical outcome, whereas that on FFE images did not. Regional analysis showed that FLAIR lesion volume in the corpus callosum correlated significantly with scores on disability and cognition scales at the first clinical assessment. FLAIR lesion volume in the frontal lobes correlated significantly with clinical scores 1 year later.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340000447
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  • 6
    Electronic Resource
    Electronic Resource
    Radiological assessment of necrosis in glioblastoma: variability and prognostic value (1998)
    Springer
    Neuroradiology 40 (1998), S. 150-153 
    Details
    ISSN: 1432-1920
    Keywords: Key words Glioblastoma ; necrosis ; Magnetic resonance imaging ; Computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a previous study, we found that the extent of necrosis was the only radiological feature which correlated significantly with survival in patients with glioblastoma. The aim of this paper was to evaluate the variability and prognostic value of the extent of the necrotic area as seen on contrast-enhanced MRI and CT in a larger series. We studied 72 patients who underwent surgical removal of supratentorial glioblastomas and had CT and/or MRI with contrast medium before surgery; 38, all undergoing the same treatment (surgery plus radiotherapy), were followed clinically. Necrosis within the tumour varied greatly, ranging from none (only 1 case) to involvement of 76 % of the tumour. Survival data in the subgroup suggested that only patients with a small area of necrosis (less than 35 % of the tumour) had a significantly longer survival time. When necrosis involved more than 35 % of the mass, patients had a shorter survival time, without any further correlation with the extent of necrosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050556
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Supratentorial glioblastoma: neuroradiological findings and survival after surgery and radiotherapy (1996)
    Springer
    Neuroradiology 38 (1996), S. S26 
    Details
    ISSN: 1432-1920
    Keywords: Key words Glioblastoma ; Computed tomography ; Magnetic resonance imaging ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Few studies have attempted to correlate neuroimaging with outcome in patients with glioblastoma. Our aim was to evaluate the relationship between neuroradiological findings and survival in these patients. We studied 18 consecutive patients with glioblastoma who had undergone surgery and radiotherapy. We assessed the following features, using preoperative CT and/or MRI: tumour size, extent of necrotic area within the mass, extent of perifocal oedema and contrast enhancement. The mean survival was 14.2 ± 5 months (range 6–22). The extent of radiological evidence of necrosis within the mass correlated significantly with survival time, whereas tumour size, perifocal oedema and contrast enhancement did not.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050913
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  • 8
    Electronic Resource
    Electronic Resource
    Supratentorial glioblastoma: Neuroradiological findings and survival after surgery and radiotherapy (1996)
    Springer
    Neuroradiology 38 (1996), S. S26 
    Details
    ISSN: 1432-1920
    Keywords: Glioblastoma ; Computed tomography ; Magnetic resonance imaging ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Few studies have attempted to correlate neuroimaging with outcome in patients with glioblastoma. Our aim was to evaluate the relationship between neuroradiological findings and survival in these patients. We studied 18 consecutive patients with glioblastoma who had undergone surgery and radiotherapy. We assessed the following features, using preoperative CT and/or MRI: tumour size, extent of necrotic area within the mass, extent of perifocal oedema and contrast enhancement. The mean survival was 14.2 ± 5 months (range 6–22). The extent of radiological evidence of necrosis within the mass correlated significantly with survival time, whereas tumour size, perifocal oedema and contrast enhancement did not.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02278114
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  • 9
    Electronic Resource
    Electronic Resource
    Pleomorphic xanthoastrocytoma with CT and MRI appearance of meningioma (1999)
    Springer
    Neuroradiology 41 (1999), S. 30-34 
    Details
    ISSN: 1432-1920
    Keywords: Key words Pleomorphic xanthoastrocytoma ; Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe a pleomorphic xanthoastrocytoma (PXA) in a young girl whose frontal lobe location, solid structure, dural tail and MRI signal characteristics led to a preoperative diagnosis of meningioma. PXA should be considered in differential diagnosis of tumours affecting young patients with neuroradiological characteristics suggestive of meningioma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050700
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