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  • Electronic Resource  (8)
  • 2000-2004  (5)
  • 1975-1979  (3)
  • 1970-1974
  • 1960-1964
  • 2000  (5)
  • 1976  (3)
  • 1
    Electronic Resource
    Electronic Resource
    EFFECTS OF GLUCAGON ON PANCREATIC SECRETION IN THE DOG (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 3 (1976), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of glucagon on the secretion of pancreatic juice were investigated using blood-perfused canine pancreas preparations.2. Intravenous administration of glucagon (3–30 μg/kg) to the donor dog elicited a dose-dependent increase in pancreatic secretion. Intra-arterial administration of glucagon (10–100 μg) into the perfused pancreas also elicited increased secretion.3. There were slight increases in amylase concentration of the pancreatic juice with the largest doses of glucagon given by either route.4. Glucagon-induced secretion was not modified by treatment with phentolamine, propranolol, atropine, guanethidine, tetrodotoxin, haloperidol, prostaglandin F2a or calcitonin.5. The results suggest that glucagon acts directly on the exocrine cells of the canine pancreas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1976.tb00591.x
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  • 2
    Electronic Resource
    Electronic Resource
    EFFECTS OF CALCITONIN ON THE SECRETION OF PANCREATIC JUICE INDUCED BY DOPAMINE, SECRETIN AND PANCREOZYMIN (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 3 (1976), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Effects of calcitonin on dopamine-, secretin- and pancreozymin-induced pancreatic secretion were investigated in the isolated blood-perfused canine pancreas.2. The volume of pancreatic secretion induced by pancreozymin given intra-arterially (i.a.) was decreased by an i.a. infusion of 1 u/min of calcitonin, but that induced by dopamine or secretin given i.a. was not affected by calcitonin treatment.3. Amylase concentration in pancreatic juice either in spontaneous secretion in the resting state or in that of stimulated secretion by pancreozymin was decreased approximately 30% by calcitonin treatment, but amylase concentration in pancreatic juice induced by dopamine or secretin was not affected by calcitonin treatment.4. Calcitonin had no effect on bicarbonate concentration in pancreatic juice stimulated by these secretagogues.5. Calcium concentration in pancreatic juice in the resting state was reduced about 36% by calcitonin treatment. Calcitonin caused a decrease in a calcium concentration in the pancreozymin-induced secretion, but did not cause any change in the dopamine- or secretin-induced one.6. These results suggest that calcitonin may affect the secretory mechanism of the acinar cells but not that of the ductular cells, and that the acinar cells are active even in the resting state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1976.tb00600.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Asymmetry in jaw-jerk reflex latency in craniomandibular dysfunction patients with unilateral masseter pain (2000)
    Oxford, UK : Blackwell Science Ltd
    Journal of oral rehabilitation 27 (2000), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of the present study was to elucidate the effects of unilateral masseter muscle pain on the jaw-jerk reflex. The latency and peak-to-peak amplitude of bilateral electromyographic activity recorded at the masseter muscles during the jaw-jerk reflex were measured in 18 patients with craniomandibular dysfunction (CMD) with strictly unilateral masseter pain or tenderness and 10 control subjects using a computerized recording and analysis system. The reflex was elicited, at the mandibular rest position, by tapping the centre of the chin downwards with a reflex hammer incorporating a microswitch that triggered the sweep of the recording apparatus upon contact with the chin. In the CMD group, the jaw-jerk latency on the affected side (6·89±0·98 ms) was significantly shorter (P〈0·01) than that on the unaffected side (7·59±0·92 ms). In the control group, there was no difference between the jaw-jerk latencies on the right (7·06±0·64 ms) and the left (7·08±0·65 ms) sides. The range of side asymmetry for jaw-jerk latencies in the CMD group was greater than that in the control group. In six patients, the latency difference exceeded 1 ms. The asymmetry of latency of the jaw-jerk reflex was thought to be due to facilitation on the side with masseter pain or tenderness. This facilitation on the ipsilateral side might be produced by enhanced gamma drive induced by sustained nociceptive stimulation. Such effects may be related with clinically derived concepts regarding such muscle dysfunction as myospastic activity or trigger points.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.2000.00595.x
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  • 4
    Electronic Resource
    Electronic Resource
    Ebselen Decreases Ozone-Induced Pulmonary Inflammation in Rats (2000)
    Springer
    Lung 178 (2000), S. 225-234 
    Details
    ISSN: 1432-1750
    Keywords: Key words: Ozone—Pulmonary inflammation—Ebselen—Peroxynitrite.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We studied the effects of ebselen on rat lung inflammatory responses against ozone exposure. Rats were treated with ebselen every 12 h from 1 h before a single 4-h exposure to 2 ppm ozone. Treatment with ebselen (10 mg/kg) significantly decreased pulmonary inflammation as indicated by the albumin concentration and the number of neutrophils in the bronchoalveolar lavage fluid 18 h after the ozone exposure. Although treatment with ebselen did not alter the macrophage expression of inducible nitric oxide synthase after the ozone exposure, it did markedly inhibit the nitration reaction of tyrosine residues, suggesting that ebselen scavenges peroxynitrite during ozone-induced pulmonary inflammation. Treatment with ebselen also enhanced the pulmonary expression of both copper, zinc, and manganous superoxide dismutases at the same time point. These enzymes may also contribute to a decrease in the formation of peroxynitrite by lowering the concentration of superoxide. Thus, ebselen represents a useful compound for protecting against certain acute lung injuries by modulating the oxidant-related inflammatory process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004080000026
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of cordycepin on the replication of western equine encephalitis virus (1976)
    Springer
    Archives of virology 52 (1976), S. 341-345 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cordycepin (3′-deoxyadenosine) inhibited viral RNA synthesis in the replication of western equine encephalitis virus, thereby causing a reduction of virus production. The rate of inhibition of viral RNA synthesis was dependent on drug concentration and the period of treatment with the drug. These results suggest that the virus RNA synthesizing system is sensitive to the drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01315623
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  • 6
    Electronic Resource
    Electronic Resource
    A segment concept in the dissolution of stereoregular isotactic polyacrylonitrile into three dinitrile solvents, CN-(CH2) n -CN (n = 1, 2, and 3), at elevated temperatures (2000)
    Springer
    Colloid & polymer science 278 (2000), S. 352-357 
    Details
    ISSN: 1435-1536
    Keywords: Key words Isotactic polyacrylonitrile ; High-temperature dissolution ; Dinitrile solvents ; Segment mobility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The dependence of the dissolution temperature (T sol) of isotactic polyacrylonitrile (PAN) on tacticity was studied for three dinitrile solvents. A linear relationship was obtained in the inverse plots of the tacticity dependence of the T sol of PAN. A phenomenological analogy between the tacticity dependence of the T sol of isotactic PAN and the molecular-weight dependence of the glass-transition temperature of amorphous polystyrene is discussed from a thermodynamic point of view. The linear relationships in both phenomena are explained in terms of a common mechanism: a breakdown of thermodynamic competition, enthalpy, and entropy through the segment mobility. The significance of segment concept and molecular mobility at elevated temperatures are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003960050524
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  • 7
    Electronic Resource
    Electronic Resource
    Sequence analysis, gene expression, and chromosomal assignment of mouse Borg4 gene and its human orthologue (2000)
    Springer
    Journal of human genetics 45 (2000), S. 374-377 
    Details
    ISSN: 1435-232X
    Keywords: Key words Cell motility ; Binder of Rho GTPase ; CDC42 TC10 ; Borg4 ; Full-length cDNA ; Fluorescence in situ hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The Borg (binder of Rho GTPases) family proteins interact with CDC42 and TC10 in a guanosine triphosphate (GTP)-dependent manner. We have isolated a full-length cDNA of the mouse Borg4 gene, which is a member of this family. Sequence analysis revealed that this gene encoded a putative 349-amino acid protein. By reverse transcription — coupled polymerase chain reaction (RT-PCR) analysis, we observed that Borg4 was expressed ubiquitously in adult tissues. Additionally, we determined the entire cDNA sequence of the putative human Borg4 orthologue. By fluorescence in situ hybridization, mouse Borg4 and the putative human orthologue have been assigned to mouse chromosome 11E and human chromosome 17q24–25, which has been described as syntenic to the mouse region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380070012
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  • 8
    Electronic Resource
    Electronic Resource
    A novel interstitial deletion of KAL1 in a Japanese family with Kallmann syndrome (2000)
    Springer
    Journal of human genetics 45 (2000), S. 237-240 
    Details
    ISSN: 1435-232X
    Keywords: Key words Kallmann syndrome ; KAL1 ; Mutation ; Anosmia ; Hypogonadism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We identified a novel interstitial deletion that spanned from exons 5 to 10 of KAL1 in two Japanese brothers with X-linked Kallmann syndrome (KS; MIM no. 308700). Both brothers had hypogonadism, unilateral renal agenesis, and disturbance of the sense of smell, but they had no other neurological manifestations, including mental disturbance. Their mother was confirmed to be an asymptomatic carrier, by use of a comparative multiplex polymerase chain reaction (PCR) analysis. The present patients are further examples of patients with KS without mental disturbance caused by a mutation confined to KAL1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380070033
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