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  • Electronic Resource  (4)
  • 1990-1994  (4)
  • 1980-1984
  • 1993  (4)
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  • Electronic Resource  (4)
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  • 1990-1994  (4)
  • 1980-1984
Year
  • 1
    Electronic Resource
    Electronic Resource
    Calcium supplementation in osteoporosis (1993)
    Springer
    Osteoporosis international 3 (1993), S. 159-162 
    Details
    ISSN: 1433-2965
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although calcium is the most abundant inorganic constituent of the bone, indispensable for the maintenance of its physical strength, the role of calcium nutrition in the development of osteoporosis and the preventive and therapeutic significance of calcium supplementation in osteoporosis have been matters of intense controversy. The wide difference in the baseline nutritional intake of calcium among different groups and the variation in age of the patients studied may have been contributory factors. Emphasis has so far been placed on the rapid bone loss in the immediate postmenopausal period predominantly influenced by estrogen deficiency which has overshadowed the effect of calcium. The strong dependence of the effect of calcium preparation used tends to be forgotten. In the present study employing oyster shell electrolysate as the calcium source in patients with a mean age of approximately 80 years, bone mineral density was kept significantly higher than in age-matched, non-supplemented patients over a period of 2 years. In separate experimental studies, rats maintained on 2% calcium showed higher bone mineral content and lived longer than did controls maintained on 1% calcium. Age-associated deterioration of renal function and hyperlipidemia were also prevented by calcium supplementation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01621895
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Histochemical demonstration of copper in LEC rat liver (1993)
    Springer
    Histochemistry and cell biology 100 (1993), S. 249-256 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Livers of LEC rats were histochemically stained for copper according to the modified Timm's method, which includes trichloroacetic acid (TCA) treatment. TCA pretreatment was effective in removing zinc and iron, leaving copper as the major metal in the liver. Hepatocytes in 3-month-old rats were stained intensely by the modified Timm's method, both in frozen sections and in paraffin-embedded specimens. The centrilobular hepatocytes were usually stained, but positive cells were also randomly distributed in the hepatic lobes, showing a mosaic pattern. The staining was intensified in 8- compared to 3-month-old LEC rats. In contrast hepatocytes from LEA rats, the normal counterpart of LEC rats, were faintly stained for copper. Proliferating cholangioles found in older LEC rats were shown to lack copper deposition, and hepatocellular carcinoma showed less copper deposits than the hepatocytes surrounding the tumor. The copper staining was augmented in livers of LEC rats subjected to copper-loading, but was less intense in the livers treated with d-penicillamine. The staining intensity under the various experimental conditions showed good correlation with the copper concentration. Lysosomal deposition of copper in hepatocytes was demonstrated by electron microscopic analysis for copper. Thus the modified Timm's method was shown to produce valuable results in demonstrating copper in LEC rat livers, providing important information for an understanding of the mechanism of copper deposition and hepatic disease of the animal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00270043
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Neuronal pp60c-src(+) in the developing chick spinal cord as revealed with anti-hexapeptide antibody (1993)
    Springer
    Journal of neurocytology 22 (1993), S. 244-258 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Polyclonal antibody was raised in rabbits against a synthetic hexapeptide R-K-V-D-V-R corresponding to a unique amino acid sequence of the neuron-specific c-src gene product pp60c−src(+). The antibody was purified by affinity chromatography. A single band with an apparent molecular mass of 60 kDa was recognized when the supernatant of homogenates of brain and spinal cord from chick embryos and chicks was probed with the affinity purified anti-hexapeptide antibody after SDS-polyacrylamide gel electrophoresis followed by Western blotting. Specificity of the antibody was further characterized by autophosphorylation assay of immunoprecipitate in comparison with the monoclonal antibody 327. Immunocytochemical studies by light microscopy revealed that pp60c−src(+) was localized in flake-like aggregates in neuronal cell bodies of the spinal cord in 7-15-day-incubated chick embryos and newly hatched chicks. Developing spinal ganglia and muscle cells were also immunoreactive at early developmental stages. By electron microscopy, the reaction product was observed mainly in two regions. One region was at polysomes and along the membranes of the rough endoplasmic reticulum. The other region was along the neuronal plasma membrane — at subsurface cisterns and at synapses. At synapses, the postsynaptic density, presynaptic membrane and synaptic vesicle membranes were immunostained. Immunoreactivity at synapses was more frequently observed at earlier stages than at later stages of development. These findings suggest that pp60c−src(+) is actively produced in developing neurons and has some important roles in synaptogenesis. In mature synapses, pp60c−src(+) may be involved in the interaction of synaptic vesicles with the presynaptic membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01187123
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Structural requirement for catalytic activity of cobalt Schiff base complex in oxygenation of alkenes (1993)
    Springer
    Reaction kinetics and catalysis letters 49 (1993), S. 1-6 
    Details
    ISSN: 1588-2837
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Kinetics of the oxygenation of styrene catalyzed by cobalt Schiff base complex [(Co(L)] shows that the reaction rate depends on the shape but not on the redox potential of Co(L). Magnetism of Co(L) is important for product distribution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02084021
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    Paper (German National Licenses)
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