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  • Electronic Resource  (7)
  • 1995-1999  (7)
  • 1905-1909
  • 1995  (7)
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  • Electronic Resource  (7)
Years
  • 1995-1999  (7)
  • 1905-1909
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  • 1
    Electronic Resource
    Electronic Resource
    DNA Ploidy as a Significant Predictor of Recurrence-Free Survival in Male Patients with Breast Cancer (1995)
    Oxford, UK : Blackwell Publishing Ltd
    The @breast journal 1 (1995), S. 0 
    Details
    ISSN: 1524-4741
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: DNA flow cytometry has been extensively studied in female breast carcinoma. However, there is limited data evaluating DNA ploidy in male breast cancer. In order to further assess the prognostic significance of DNA ploidy in male breast carcinoma, we retrospectively reviewed 55 cases (52 patients) of histologically proven male breast carcinoma treated at our institution from January 1971 through January 1992. Of the 55 cases, 32 paraffin-embedded blocks were available for DNA flow cytometry analysis. As of June 1993, median follow-up is 7.0 years. In the overall population of 55 cases, univariate analysis identified TNM stage, tumor size, and nodal status as significant prognostic indicators of overall survival and disease-free survival. In the 32 cases available for DNA flow cytometry, both local recurrences and distant metastases were more frequent in the aneuploid population. Univariate analysis revealed DNA ploidy to be a significant prognostic factor for local recurrence-free survival and distant metastasis-free survival. DNA ploidy correlated significantly with stage at diagnosis (p =.04), tumor size (p =.04) and nodal status (p =.02). In a multivariate analysis of 26 patients on whom all data were available (DNA ploidy, tumor size, clinical stage and nodal status), DNA ploidy was an independent predictor of disease-free survival (p =.05). In this retrospective analysis, we conclude that DNA ploidy has prognostic significance in male breast carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1524-4741.1995.tb00262.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    An unusual Phytophthora associated with widespread alder mortality in Britain (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Plant pathology 44 (1995), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: During 1993 and 1994 an unusual Phytophthora was consistently isolated from bark lesions at the stem bases of dying alder in Southern Britain. The Phytophthora resembles P. cambivora in both its gametangial and sporangial morphology. However, it is distinct from this species in being homothallic rather than outcrossing; in producing a significant proportion of small and sometimes partially developed oogonia; in having a high frequency of oosphere abortion; in having an appressed felty colony type with little or no aerial mycelium; and in exhibiting a lower optimum temperature for growth (c.22-5°C) and lower growth temperature maximum (c.29°C) on carrot agar than P. cambivora (c.27-5° and 33-5°C respectively). An inoculation test confirmed its pathogenicity to Alnus. The status of the alder Phytophthora is discussed. On the basis of its unusual characteristics and unusual host it is suggested that it might be a new or recently introduced organism rather than a previously unrecorded indigenous variant of P. cambivora.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3059.1995.tb02658.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Uptake of systemically administered human anticerebellar antibody by rat Purkinje cells following blood-brain barrier disruption (1995)
    Springer
    Acta neuropathologica 89 (1995), S. 341-345 
    Details
    ISSN: 1432-0533
    Keywords: Purkinje cells ; Blood-brain barrier ; Human anticerebellar antibody ; Rat ; Paraneoplastic syndromes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Paraneoplastic cerebellar degeneration accompanying gynecological or breast malignancies is frequently associated with an autoantibody response, termed “type I” or “anti-Yo” directed against cytoplasmic antigens of cerebellar Purkinje cells. The role of this antibody response in the pathogenesis of paraneoplastic cerebellar degeneration is unknown; however, it is also not known whether anti-Purkinje cell antibodies from the systemic circulation bind to target Purkinje cell antigens under the conditions of brain inflammation and blood-brain barrier disruption, which are frequently present at the onset of cerebellar symptoms. Inbred Lewis rats received intraperitoneal injections of type I or normal IgG in the setting of blood-brain barrier disruption induced by adoptive transfer of experimental allergic encephalomyelitis (EAE) and were killed after 24, 48, and 96h. Brains of these animals were studied histologically for evidence of EAE and immunohistochemically for binding of human or endogenous rat IgG to target neurons. Rat IgG was detected around vessels and in Purkinje cells of all animals studied. Human IgG was detected around vessels of all animals. In animals examined 96 h after receiving type I human IgG, human IgG was identified within processes of Purkinje cells and within occasional Purkinje cell bodies. Uptake of type I IgG by other cell types was not observed, and neuronal uptake of IgG was not seen in brains of animals receiving normal human IgG. Our data demonstrate that circulating type I IgG is internalized by cerebellar Purkinje cells in the setting of blood-brain barrier disruption and suggest a mechanism by which an antibody response directed against cytoplasmic antigens of Purkinje cells may reach target antigens at the onset of paraneoplastic cerebellar degeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309627
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Uptake of systemically administered human anticerebellar antibody by rat Purkinje cells following blood-brain barrier disruption (1995)
    Springer
    Acta neuropathologica 89 (1995), S. 341-345 
    Details
    ISSN: 1432-0533
    Keywords: Key words Purkinje cells ; Blood-brain barrier ; Human anticerebellar antibody ; Rat ; Paraneoplastic syndromes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Paraneoplastic cerebellar degeneration accompanying gynecological or breast malignancies is frequently associated with an autoantibody response, termed "type I" or "anti-Yo" directed against cytoplasmic antigens of cerebellar Purkinje cells. The role of this antibody response in the pathogenesis of paraneoplastic cerebellar degeneration is unknown; however, it is also not known whether anti-Purkinje cell antibodies from the systemic circulation bind to targe t Purkinje cell antigens under the conditions of brain inflammation and blood-brain barrier disruption, which are frequently present at the onset of cerebellar symptoms. Inbred Lewis rats received intraperitoneal injections of type I or normal IgG in the setting of blood-brain barrier disruption induced by adoptive transfer of experimental allergic encephalomyelitis (EAE) and were killed after 24, 48, and 96 h. Brains of these animals were studied histologically for evidence of EAE and immunohistochemically for binding of human or endogenous rat IgG to target neurons. Rat IgG was detected around vessels and in Purkinje cells of all animals studied. Human IgG was detected around vessels of all animals. In animals examined 96 h after receiving type I human IgG, human IgG was identified within processes of Purkinje cells and within occasional Purkinje cell bodies. Uptake of type I IgG by other cell types was not observed, and neuronal uptake of IgG was not seen in brains of animals receiving normal human IgG. Ou r data demonstrate that circulating type I IgG is internalized by cerebellar Purkinje cells in the setting of blood-brain barrier disruption and suggest a mechanism by which an antibody response directed against cytoplasmic antigens of Purkinje cells may reach target antigens at the onset of paraneoplastic cerebellar degeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309627
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Haloperidol increases smoking in patients with schizophrenia (1995)
    Springer
    Psychopharmacology 119 (1995), S. 124-126 
    Details
    ISSN: 1432-2072
    Keywords: Schizophrenia ; Smoking ; Nicotine ; Haloperidol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ten patients with schizophrenia participated in 120-min free-smoking sessions when actively psychotic and free of antipsychotic medications, and again after the initiation of haloperidol treatment. During these free-smoking sessions they had access to cigarettes ad libitum. Their expired air carbon monoxide (CO) and plasma nicotine and cotinine levels were measured at the end of the 120-min free-smoking sessions. These patients smoked more after starting haloperidol treatment, relative to their baseline rate of smoking when free of antipsychotic medications, as evidenced by significantly higher expired CO and plasma nicotine levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246063
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    The yield behaviour of poly(phenylenebibenzimidazole) (1995)
    Springer
    Journal of materials science 30 (1995), S. 5328-5334 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The compressive yield behaviour of poly(2,2′-m-phenylene-5,5′-bibenzimidazole) (PBI) has been studied over a wide range of temperatures. The tensile behaviour was also studied under superimposed hydrostatic pressure. In both cases wet and dry samples were examined and the results revealed the considerable effects of moisture on the mechanical properties of PBI. The results of all these tests show that PBI has a remarkably high shear yield stress at room temperature. This results in a very high compressive yield stress and a very high tensile yield stress observed under superimposed hydrostatic pressure when brittle failure from surface flaws is prevented. It is concluded on the basis of quantitative analysis that the yield mechanism in PBI at room temperature is initiation controlled, as in a metal or ceramic, rather than a velocity controlled, thermally activated, viscoelastic process which is generally considered applicable in polymers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00351542
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Approaches for the generation of stress waves in concrete (1995)
    Springer
    Experimental mechanics 35 (1995), S. 36-41 
    Details
    ISSN: 1741-2765
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract This paper reviews several existing, as well as potential, stress-wave-generating techniques for concrete. The generating techniques under study include standard ultrasonic pulse generators, high-energy ultrasonic toneburst systems, and simple impact. In addition, the use of laser sources and ultrasonic lithotripters are proposed. The novelty of this review is that the methods are analyzed considering applications to existing concrete NDE methods. The strengths and weaknesses of each generation technique are discussed. Some of the methods are demonstrated through laboratory tests on a variety of specimen types. A description of each technique and conclusions concerning the appropriateness of each technique are also made.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02325832
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    Paper (German National Licenses)
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