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  • Electronic Resource  (3)
  • 2005-2009  (1)
  • 1955-1959  (2)
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  • Electronic Resource  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    Lack of apoptosis of Sézary cells in the circulation following oral bexarotene therapy (2005)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 152 (2005), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Apoptosis of malignant cells has been suggested as an important mechanism of the action of bexarotene in the treatment of cutaneous T-cell lymphoma (CTCL).Objectives  Our purpose was to examine the in vivo and in vitro responses of patients with Sézary syndrome treated with oral bexarotene and assess them for apoptosis of the Sézary cells.Methods  Six patients with CTCL with circulating Sézary cells, participating in a clinical trial of oral bexarotene (300 mg m−2 daily) were included in the study. Peripheral blood from the patients was analysed for in vivo and in vitro apoptosis.Results  None of the six patients demonstrated in vivo apoptosis. In vitro apoptosis of Sézary cells was demonstrated in one patient following exogenous bexarotene.Conclusions  Apoptosis is not detectable in the circulation of patients with Sézary syndrome treated with bexarotene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06539.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Chlorothiazid in Diabetes Insipidus (1959)
    [s.l.] : Nature Publishing Group
    Nature 183 (1959), S. 891-892 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Much more severe and sustained diabetes insipidus can be induced in the rat by electrolytic damage to the hypothalamus2 than by the more usual technique of surgical removal of the posterior lobe of the pituitary gland. The technique consists of complete, or almost complete, destruction of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/183891a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    An Antimineralocorticoid Action of some Saluretic Sulphonamides (1959)
    [s.l.] : Nature Publishing Group
    Nature 184 (1959), S. 1492-1493 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Further investigation has shown: (1) The antidiuretic property is shared by two halogenated sulphonamides ('Hygroton' and G 32359) in which the halogen and sulphamyl group are in the ortho position, but which otherwise bear little structural resemblance to chlorothiazide. The chemical names of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1841492a0
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    Paper (German National Licenses)
    Fulltext
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