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  • Electronic Resource  (3)
  • 2000-2004  (1)
  • 1975-1979  (2)
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  • Electronic Resource  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    Single nucleotide polymorphism screening and association analysis – exclusion of integrin β7 and vitamin D receptor (chromosome 12q) as candidate genes for asthma (2004)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 34 (2004), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background The human genes coding for integrin β7 (ITGB7) and vitamin D receptor (VDR) are two of the several candidate genes for asthma and related phenotypes found in a promising candidate region on chromosome 12q that has been identified in multiple genomewide screens and candidate gene approaches.Methods All exons, including parts of the neighbouring introns, and the predicted promoter region of the ITGB7 gene were screened for common polymorphisms in 32 independent asthmatic and healthy probands, resulting in the detection of two single nucleotide polymorphisms (SNPs) unknown so far. In addition to these SNPs, five already described SNPs of the ITGB7 and one in the human VDR gene were analysed in a Caucasian sib pair study of 176 families with at least two affected children, using matrix assisted laser desorption/ionization time of flight mass spectrometry. All confirmed SNPs were tested for linkage/association with asthma and related traits (total serum IgE level, eosinophil cell count and slope of the dose–response curve after bronchial challenge).Results Two new variations in the ITGB7 gene were identified. The coding SNP in exon 4 causes a substitution of the amino acid GLU by VAL, whereas the other variation is non-coding (intron 3). None of the eight analysed SNPs, of either the ITGB7 or the VDR genes, showed significant linkage/association with asthma or related phenotypes in the family study.Conclusions These findings indicate that neither the human ITGB7 nor the VDR gene seem to be associated with the pathogenesis of asthma or the expression of related allergic phenotypes such as eosinophilia and changes in total IgE level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2004.02047.x
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  • 2
    Electronic Resource
    Electronic Resource
    Rasterelektronenmikroskopische befunde an der orthoergisch geschädigten hautoberfläche haarloser mäuse (1976)
    Springer
    Archives of dermatological research 255 (1976), S. 225-230 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Definierte mechanisch-chemische Irritation der Hautoberfläche haarloser Mäuse führt regelmäßig zu makroskopisch subvisiblen Hornschicht-Veränderungen. Bei rasterelektronenmikroskopischer Analyse lassen sich in den Irritationsbezirken gegenüber normaler Kontrollhaut regelhaft ausgedehnte Hornschicht-Dehiszenzen und tiefere Riß- oder Grabenbildungen nachweisen. Das jeweils vorliegende Schädigungsmuster der Hornschicht hängt in gewissen Grenzen ab von der Art, Intensität und Dauer der Reizung. Die haarlose Maus erweist sich als ein für orientierende Hautbelastungsstudien geeignetes Versuchstier.
    Notes: Summary Mechanic-chemically defined irritation of the skin surface of hairless mice regularly leads to macroscopically sub-visible changes of the horny layer. Scanning electron-microscopic analysis reveals extended regular horny layer dehiscences, as well as deeper dehiscence or trench formations in the area of irritation, as compared to normal skin. The damaged horny layer sample, presented respectively, depends—to a degree-upon type, intensity and duration of irritation. Hairless mice proved to be best suited as test animals for informative studies concerning cutaneous resistance to stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561491
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Side-effects of local anesthetics on the corneal epithelium of the rabbit eye (1975)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 197 (1975), S. 71-81 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Raster- und transmissionselektronenmikroskopisch werden 15 Kaninchenhornhäute nach Novesin 0,4%und 15 nach Chibro-Keracain in Abständen von 3, 6, 10, 15 und 60 min auf toxische Nebenwirkungen untersucht. Die Läsionen nach Keracain waren ausgeprägter und traten rascher ein. 60 min nach Applikation sind die Reparationsvorgänge bei Novesin weitgehendst abgeschlossen. Die Präparate nach Keracain zeigen zu diesem Zeitpunkt ein in seiner Funktion noch beeinträchtigtes Oberflächenepithel.
    Notes: Summary The toxic side-effects of 0.4% Novesine and Chibro-Kerakain were investigated by scanning- and transmission electron microscopy in 15 rabbit corneae each in intervals of 3, 6, 10, 15 and 60 mins. The lesions following Kerakain were larger and occurred earlier. After 60 mins, the specimens after Novesine application showed an almost complete repair process, whereas after Kerakain the epithelial surface appeared to be functionally impaired.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00506644
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    Paper (German National Licenses)
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