Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    An integrated software environment for multi-disciplinary computational engineering (1999)
    Bradford : Emerald
    Engineering computations 16 (1999), S. 913-934 
    Details
    ISSN: 0264-4401
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Technology
    Notes: As computer simulation increasingly supports engineering design and manufacture, the requirement for a computer software environment providing an integration platform for computational engineering software increases. The potential benefits to industry are considerable. As a first step in the long-term development of such a system, a computer software environment has been developed for pre- and post-processing for unstructured grid-based computational simulation. Arbitrary computer application software can be integrated into the environment to provide a multi-disciplinary engineering analysis capability within one unified computational framework. Recognising the computational demands of many application areas, the environment includes a set of parallel tools to help the user maximise the potential of high performance computers and networks. The paper will present details of the environment and include an example of, and discussion about, the integration of application software.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/02644409910304176
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    A Cobalt Aluminophosphate with Encapsulated Ethylenediamine: Co0.65Al0.35PO4.0.5NH2.65CH2CH2NH2.65 (1998)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 54 (1998), S. 1564-1566 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270198006842
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    A pilot study of melphalan, tumor necrosis factor-α and 41.8 °C whole-body hyperthermia (1999)
    Springer
    Cancer chemotherapy and pharmacology 43 (1999), S. 409-414 
    Details
    ISSN: 1432-0843
    Keywords: Key words Whole body hyperthermia ; Melphalan ; Tumor necrosis factor ; Melanoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: To evaluate the feasibility of sequencing (based on preclinical modeling) tumor necrosis factor-α (TNF) at two dose levels with melphalan (L-PAM) and 41.8 °C whole-body hyperthermia (WBH)  for 60 min. Patients and methods: Nine patients with refractory cancer were treated from October 1995 to June 1997. The study encompassed a total of 20 trimodality treatment courses. Three patients were treated at TNF dose level I (50 μg/m2) and six patients were treated at TNF dose level II (100 μg/m2). TNF was delivered as a 24-h intravenous infusion, 48 h prior to the combination of L-PAM and WBH; L-PAM was given over 10 min at target temperature at a dose of 17.5 mg/m2 based on a previous phase I WBH/L-PAM trial. WBH was administered with an Aquatherm radiant heat device. Results: Myelosuppression was the major toxicity associated with therapy, but there were no instances of bleeding or neutropenic fevers. Grade 3 thrombocytopenia was seen with 15% of treatments. Regarding absolute neutrophil count, 15% of treatments were associated with grade 3 toxicity, and 45% with grade 4 toxicity, and regarding white blood cell count, 50% of treatments were associated with grade 3 toxicity and 10% with grade 4 toxicity. The myelosuppression observed was equivalent to that seen in our earlier phase I study of WBH and L-PAM (without TNF). Only mild toxicities (grade 1 or 2) were associated with TNF; these were seen with ≤25% of treatments and included nausea, vomiting, diarrhea, fevers, and headache. There were no instances of hypotension. There was no relationship between toxicities observed and the two TNF dose levels. Mild WBH toxicities were seen with less than 15% of treatments; these included nausea, vomiting, and herpes simplex I. Responses included two complete remissions (malignant melanoma, TNF dose level I; breast cancer, TNF dose level II), and two disease stabilizations (both malignant melanoma, TNF dose level I). Conclusion: We conclude that the combination of TNF, L-PAM, and WBH is well tolerated at the dose levels studied. The clinical results justify further clinical investigation for this trimodality treatment approach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050915
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Development of DNA probes for the ovine Eimeria speciesE. crandallis andE. ovinoidalis (1995)
    Springer
    Parasitology research 81 (1995), S. 222-229 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract As an alternative to morphological speciation, DNA probes have been developed to identifyEimeria crandallis andE. ovinoidalis, the species associated with ovine coccidiosis. Coccidia-free lambs were infected with pure cultures ofE. crandallis andE. ovinoidalis. Oocysts separated from faeces were sporulated and treated to release sporozoites from which DNA was purified. Repetitive DNA sequences were identified by hybridisation and cloned. The specificity of selected clones was tested by hybridisation with dot blots of four other ovineEimeria species, a mixture of caprineEimeria species andE. acervulina of the chicken. The probes allowed the detection of DNA equivalent to that present in approximately 1,500 oocysts. To increase the sensitivity of the test, a polymerase chain reaction (PCR) approach was adopted, using oligonucleotide primers specific for the cloned repeats. By this method, less than 10 oocysts ofE. ovinoidalis could be reliably detected. In addition to the species-specific probes, other highly repetitive DNA sequences fromE. crandallis andE. ovinoidalis were cloned and sequenced; these repeats hybridised to all ovine, caprine and avianEimeria species tested and contained tandem CGA and putative telomeric repeats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00937113
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    A quadratic boundary element for potential problems in 2D with no numerical integration (1995)
    Chichester : Wiley-Blackwell
    Communications in Numerical Methods in Engineering 11 (1995), S. 391-401 
    Details
    ISSN: 1069-8299
    Keywords: boundary element method ; two-dimensional potential problems ; logarithmic kernel ; derivative kernal ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Both the logarithmic and derivative kernel integrations for potential problems, solved with quadratic isoparametric boundary elements, contain quartic functions of the integration parameter. It is shown that such functions can be written as the product of two quadratic functions with real coefficients. The derivative kernel integration is then represented as the sum of two integrals, which can be evaluated analytically. The logarithmic kernel integration can be similarly split but needs a Taylor series expansion of the Jacobian of the integration to enable analytical integration. The use of this Taylor series expansion means that the method presented is limited to problems involving weakly curved elements.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cnm.1640110503
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Localization and diurnal expression of mRNA encoding the β1-adrenoceptor in the rat pineal gland: an in situ hybridization study (1997)
    Springer
    Cell & tissue research 288 (1997), S. 279-284 
    Details
    ISSN: 1432-0878
    Keywords: Key words: Adrenoceptors ; Diurnal rhythms ; Regulation ; In situ hybridization ; Pineal gland ; Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The rat pinealocyte is stimulated by norepinephrine, which is released from sympathetic nerve fibers innervating the gland. Norepinephrine binds to β1-adrenoceptors situated on the pinealocyte cell membrane. Ligand binding to these receptors exhibits a diurnal rhythm, with the largest number occurring in the late part of the light phase when the release of norepinephrine is minimal. By using in situ hybridization with a cDNA antisense oligonucleotide probe recognizing mRNA encoding the rat β1-adrenoceptor, we have demonstrated a stronger hybridization signal in the rat pineal gland than in other brain regions. Cells containing β1-mRNA are located in the superficial pineal gland, the deep pineal gland, and the pineal stalk. However, the number of receptors varies considerably between the individual pinealocytes. The β1-mRNA in situ hybridization signal for mRNA encoding the β1-adrenoceptor of the rat pineal has been quantified over a 24-h period; the strongest signal is found at mid-dark and the weakest signal at mid-light, indicating that the transcriptional regulation of β1-mRNA synthesis in the rat pineal is diurnal. In addition, maximal receptor protein expression occurs late in the light phase in the rat pineal and is thus considerably delayed compared with its peak mRNA synthesis. This lag time indicates that the β1-receptor is regulated at the translational or post-translational level. Removal of the sympathetic input to the pineal gland by superior cervical ganglionectomy decreases the β1-mRNA signal in the gland.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410050813
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Field Calibration of a Capacitance Water Content Probe in Fine Sand Soils (1999)
    Springer
    Soil Science Society of America journal 63 (1999), S. 987-989 
    Details
    ISSN: 1435-0661
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: v ) of 〈0.10 cm3 cm-3 after drainage due to gravity has ceased. Small changes in θv in the range of 0.02 to 0.08 cm3 cm-3 can greatly affect plant available water and, therefore, good calibration of soil water content sensors is necessary. The EnviroSCAN (Sentek Pty. Ltd., South Australia) is a multiple sensor capacitance probe capable of continuous measurement of soil water content by volume (θv). Many fine sand soils in Florida have plant available θv values of ≤0.08 cm3 cm-3. The manufacturer's calibration curve has very few data points 〈0.10 cm3 cm-3θv and no data in the 0.02 to 0.04 cm3 cm-3θv range. Because of the lack of data in this range, a calibration curve from 0.02 to 0.08 cm3 cm-3θv was developed for Candler fine sand (hyperthermic, uncoated Typic Quartzipsamments), Apopka fine sand (loamy, siliceous, hyperthermic Grossarenic Paleudults), and Immokalee fine sand (sand, siliceous, hyperthermic Arenic Alaquods) in two locations in Florida. Since calibration curves for the three soils did not differ significantly, data from the three soils were combined. An exponential calibration curve was developed (RMSE = 0.0085, R2 = 0.83). This equation provides substantially different estimates of water content in the 0.02 to 0.08 range than values obtained from the manufacturer's calibration. This improved calibration extends the range of the EnviroSCAN to include an important group of soils with very low water holding capacity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Evolution of a repeat sequence in the parathyroid hormone-related peptide gene in primates (1995)
    Springer
    Mammalian genome 6 (1995), S. 408-414 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A polymorphism of the variable number of tandem repeat (VNTR) type is located 97 bp downstream of exon VI of the parathyroid hormone-related peptide (PTHrP) gene in humans. The repeat unit has the general sequence G(TA)nC, where n equals 4–11. In order to characterize the evolutionary history of this VNTR, we initially tested for its presence in 13 different species representing four main groups of living primates. The sequence is present in the human, great apes, and Old World monkeys, but not in New World monkeys; and this region failed to PCR amplify in the Loris group. Thus, the evolution of the sequence as part of the PTHrP gene started at least 25–35 millions years ago, after divergence of the Old World and New World monkeys, but before divergence of Old World monkeys and great apes and humans. The structural changes occurring during evolution are characterized by a relatively high degree of sequence divergence. In general, the tandem repeat region tends to be longer and more complex in higher primates with the repeat unit motifs all being based on a TA-dinucleotide repeat sequence. Intra-species variability of the locus was demonstrated only in humans and gorilla. The divergence of the TA-dinucleotide repeat sequence and the variable mutation rates observed in different primate species are in contrast to the relative conservation of the flanking sequences during primate evolution. This suggests that the nature of the TA-dinucleotide repeat sequence, rather than its flanking sequences, is responsible for generating variability. Particular features of the sequence may allow it to form stable secondary structures during DNA replication, and this, in turn, could promote slipped-strand mispairing to occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00355642
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Natural resistance to infection with Legionella pneumophila: chromosomal localization of the Lgn1 susceptibility gene (1995)
    Springer
    Mammalian genome 6 (1995), S. 540-545 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Legionella pneumophila is a strict intracellular pathogen that replicates in the professional phagocytes of the human and guinea pig host. Although murine macrophages from most inbred strains are non-permissive to intracellular replication of L. pneumophila, inflammatory macrophages from the mouse strain A/J are completely permissive to intracellular replication of this bacterium. This genetic difference is controlled by the expression of a single autosomal gene designated Lgn1, with non-permissiveness behaving as completely dominant over permissiveness. We have used a total of 25 AXB/BXA recombinant inbred mouse strains and 182 (A/JxC57BL/6J)xA/J segregating backcross progeny (A/J, permissive; C57BL/6J, non-permissive) to map the Lgn1 gene. Animals were individually type for tolerance to intracellular replication by in vitro infection of their inflammatory macrophages with L. pneumophila. All animals segregated into two non-overlapping groups. Examination of the strain distribution pattern of the AXB/BXA strains for Lgn1 initially identified linkage to Chromosome (Chr) 13 markers. Genotyping of the 25 AXB/BXA strains and the 182 backcross progeny for 11 Chr 13 markers established that Lgn1 mapped to Chr 13, with the gene order and intergene distance D13Mit231-(5.5±1.5)-D13Mit193-(2.2±0.9)-D13Mit194-(1.1±0.6)-D13Mit128-(2.6±1.0)-Lgn1-(2.2±0.9)-D13Mit70-(3.9±1.3)-D13Mit73-(7.2±1.7)-D13Mit53-(0.7±0.5)-D13Mit32-(0.7±0.5)-D13Mit77-(0.7±0.5)-D13Mit78. This portion of Chr 13 is homologous to the distal portion of human Chr 5, 5q11–5q13, suggesting a possible location of a human LGN1 homolog. Understanding the molecular basis of the high permissiveness of A/J macrophage to L. pneumophila may shed light on the survival strategy of this bacterium in highly permissive human phagocytes. This may be achieved by positional cloning of Lgn1, and the identification of the Lgn1 subchromosomal region reported here is a first step towards that goal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00356173
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    SPLIT, CHARACTERISTIC BASED SEMI-IMPLICIT ALGORITHM FOR LAMINAR/TURBULENT INCOMPRESSIBLE FLOWS (1996)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 23 (1996), S. 787-809 
    Details
    ISSN: 0271-2091
    Keywords: operator-splitting ; general algorithm ; characteristic-Galerkin ; laminar/turbulent ; incompressible ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In an earlier paper, Zienkiewicz and Codina (Int. j. numer. methods fluids, 20, 869-885 (1995)) presented a general algorithm for the solution of both compressible and incompressible Navier-Stokes equations. The algorithm, based on operator splitting, permits arbitrary interpolation functions to be used while avoiding the Babŭska-Brezzi restriction. In addition, its characteristic based approach introduces a form of rational dissipation. Zienkiewicz et al. (Int. j. numer. methods fluids, 20, 887-913 (1995)) presented the application of this algorithm in its fully explicit form to various inviscid compressible flow problems. They also presented two incompressible flow problems solved by the fully explicit form, employing a pseudo compressibility. The present work deals with the application of the above algorithm it its semi-implicit form to some incompressible flow benchmark problems. Further, it extends the methodology to turbulent flows by employing both one, and two equation turbulence models. A comparison of results with earlier investigations is presented. Other issues addressed in this study include the effect of additional diffusion terms present in the scheme for both laminar and turbulent flow problems and some practical difficulties associated with local time stepping.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...