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  • Electronic Resource  (2)
  • 1980-1984  (1)
  • 1975-1979  (1)
  • 1
    ISSN: 1432-0533
    Keywords: Hirano body ; Neurofilament ; Peripheral nerve ; Neuromuscular junction ; Progressive external ophthalmoplegia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Inclusions, ultrastructurally identical with Hirano bodies which were previously believed to be limited to the central nervous system (CNS), were found both within peripheral myelinated nerve axons and within terminal axons of neuromuscular junctions in the ocular muscles of an autopsied woman who had suffered from progressive external ophthalmoplegia with multisystemic involvements. Electron micrographs showed the inclusions to consist of beaded filaments or lattice-like structures with filamentous elements continuing onto neurofilaments in the axon. The corelation of these new pathological findings in peripheral nerve axons and ophthalmoplegia is discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 34 (1976), S. 311-319 
    ISSN: 1432-0533
    Keywords: Parkinson's disease ; Lewy bodies ; Monoamine neuron system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A systematic study of the central and peripheral nervous systems in 3 cases of Parkinson's disease has demonstrated that Lewy bodies are present in 27 nuclei. Of these 20 nuclei (12 pigmented and 8 unpigmented) are involved in 2 or all 3 cases. It is noticed that the distribution of Lewy bodies in Parkinson's disease described here corresponds surprisingly well to that of monoamine (dopamine, noradrenaline and serotonin) cell bodies demonstrated in rats by the histochemical fluorescence method. This correlation is similar to that of Alzheimer's neurofibrillary changes in postencephalitic Parkinsonism as described by Ishii. Inasmuch as these viewpoints are also in agreement with previously reported biochemical data on Parkinsonism, it is suggested that Parkinsonism (idiopathic and postencephalitic) should represent a system degeneration of monoamine neuron systems.
    Type of Medium: Electronic Resource
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