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  • Electronic Resource  (5)
  • 1990-1994  (2)
  • 1970-1974  (3)
  • Cell & Developmental Biology  (4)
  • Drug Effects
  • 1
    Electronic Resource
    Electronic Resource
    Setting, patient, and doctor effects on drug response in neurotic patients (1970)
    Springer
    Psychopharmacology 18 (1970), S. 180-208 
    Details
    ISSN: 1432-2072
    Keywords: Drug Effects ; Population Effects ; Attrition ; Dosage Deviation ; Side Reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Diazepam was compared to placebo and phenobarbital sodium in a double-blind study with 472 anxious psychoneurotic patients. Patients were treated in 3 settings — medical clinic, general practice, and private psychiatric practice. The treatment setting was found to be at least as important as the medication in producing a treatment response. Drug effects were pronounced. Compared to phenobarbital patients, diazepam patients more often completed the study, followed prescribed dosage, and reported fewer side reactions. Diazepam patients did not differ from placebo patients in dosage intake or side effects, only in higher completion rate. Population effects indicated clinic patients to drop out and deviate from dosage more than private patients. General practice patients reported the most and private psychiatric patients reported the least side effects. These differences are explained in terms of patient background and behavioral patterns and of a medical as opposed to a psychiatric orientation toward treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401500
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  • 2
    Electronic Resource
    Electronic Resource
    Structure and innervation of the ciliary processes of the albino rabbit eyeThis research was supported in part by United States Public Health Service Research grant AM 11407. (1970)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 168 (1970), S. 339-349 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Various physiological and anatomical studies have suggested that the ciliary epithelium may be under the influence of adrenergic nerve fibers. This study was undertaken in an attempt to characterize the innervation of the ciliary epithelium. Both light and electron microscopy revealed that the ciliary epithelium is only sparsely innervated. In addition, the ciliary epithelium overlies a highly vascular stroma, and the distance between the large vascular channels and the ciliary epithelium is small. These features of the stroma indicate it is structurally suited for a transport function, a fact which supports earlier reports that the elaborate membrane infoldings of the ciliary epithelium are indicative of a transport function. The discrepancy between previous descriptions of the innervation of the ciliary epithelium, demonstrating complex subepithelial plexuses of adrenergic nerve fibers, and the results of the present study may be due to the fact that the fluorescence technique used in previous studies could have labelled some other tissue component in addition to adrenergic nerve fibers. Results with orcein and aldehyde fuchsin stains indicate that the disposition of elastic fibers in the ciliary processes is similar to previous descriptions of adrenergic nerve fibers as determined by fluorescent techniques.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091680302
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Localization of muscle spindles in the human Extensor indicis muscle for biopsy purposes (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 179 (1974), S. 447-451 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The number and spatial relations of muscle spindles in the extensor indicis have been determined. Approximately forty spindles lie adjacent to the motor end plate zone dispersed rather equally through this area of the muscle with a modest increase in density among the distally originating fibers. A study of the entire innervation pattern of this muscle has also been completed.These findings have greatly facilitated the isolation of spindles for electron microscopic study and attempts to perform in vivo recording from the sensory nerves of muscle spindles in this laboratory. It is now possible, with the aid of suitable magnification and stimulating and recording devices, to more rapidly find muscle spindles relative to the gross innervation and the easily located motor end plate zone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091790404
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  • 4
    Electronic Resource
    Electronic Resource
    Superficial bladder cancer: Diagnosis, surveillance and treatment (1992)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 50 (1992), S. 120-127 
    Details
    ISSN: 0730-2312
    Keywords: intravesical therapy ; superficial bladder cancer ; transitional cell carcinoma ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Approximately 70% of all bladder cancers are superficial at the time of presentation. Superfecial bladder cancer includes tumors confined to the urothelium (clinical stage Ta) or lamina propria (stage T1) and flat carcinoma is situ (stage Tis). Because the biological behavior of bladder neoplasms is variable, several important prognostic factros must be addressed. Multivariate analyses have shown that factors predictive of tumor recurrence and tumor progression include multifocal tumors, high grade tumors. T1 tumors and positive urinary cytology after transurethral resection (TUR). The patient with superficial bladder cancer should be monitored via endoscopy supplemented by urinary cytology, using either voided or bladder irrigation specimens and urinalysis. Frequent intravenous urography is not required, even in high grade tumors, as long as the clinical and pathologic studies remain negative and the patient is asymptomatic.The “gold standard” of treatment for superficial is TUR of the entire tumor. Despite TUR, new tumors will occur in approximately 50% of all patients; those at highest risk for tumor recurrence and progression require adjuvant intravesical therapy after TUR. A variety of drugs are used as intravesical therapy, including thiotepa, mitomycin C, doxorubicin hydrochloride, Bacillus Calmette-Guerin (BCG), epirubicin, and interferon. Although associated with the most toxicity, BCG appears to be the most effecacious agent in increasing the time to recurrence and progression and in reducing the recurrence rate. © 1992 Wiley-Liss, Inc.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240501323
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  • 5
    Electronic Resource
    Electronic Resource
    Lipopolysaccharide induces competence genes JE and KC in Balb/C 3T3 cells (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 144 (1990), S. 77-83 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The expression of the early genes JE and KC has been examined in Balb/c 3T3 cells treated with bacterial lipopolysaccharide (LPS). Previous studies showed that JE and KC mRNAs are induced in murine peritoneal macrophages treated with LPS, suggesting a role for these genes in inflammatory responses. Consistent with this possibility are recently published cDNA sequences which document that both genes are members of a superfamily of inflammation- and/or growth-related cytokines. In the present study, we provide evidence that the mRNAs for JE and KC are specifically induced by LPS treatment of Balb/c 3T3 cells. The LPS-stimulated expression of JE and KC was dose dependent, and exhibited a transient time course; message levels were maximal between 2 and 4 hr and declined by 8 hr. The LPS-augmented accumulation of JE and KC occurred even in the presence of cyclohexamide, which additionally had a superinducing effect on the expression of both genes. Cyclohexamide alone, in the absence of LPS, also induced JE and KC mRNA accumulation. LPS-stimulated JE and KC mRNA expression was dependent upon the stimulation of transcription as determined by nuclear “run-on” studies. Comparative analyses indicated that, under the conditions employed, LPS was a somewhat less effective stimulant of JE expression than PDGF or EGF, and was more effective than PDGF and equivalent to EGF in its ability to augment KC accumulation. Unlike PDGF and EGF, LPS did not stimulate DNA synthesis by Balb/c 3T3 cells at any time over the 72 hr period examined. The ability of the inflammatory, non-mitogenic stimulus LPS to selectively induce JE and KC mRNA expression by fibroblasts may reflect their participation in inflammation and wound healing as secretory cells.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041440111
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