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  • Electronic Resource  (2)
  • 1990-1994  (2)
  • 1955-1959
  • Benzamil  (1)
  • Extension  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Wertigkeit der präoperativen Diagnostik zur Beurteilung der Tumorausdehnung bei ductalen Pankreascarcinomen (1990)
    Springer
    Langenbeck's archives of surgery 375 (1990), S. 33-38 
    Details
    ISSN: 1435-2451
    Keywords: Preoperative diagnostics ; Pancreatic cancer ; Extension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Für die Therapieplanung beim Pankreascarcinom kann die Wertigkeit der präope-rativen Beurteilung der Tumorausdehnng von Bedeutung sein. Bei 449 Patienten wurde retrospektiv und bei 35 Patienten prospektiv die Wertigkeit der präoperativen Diagnostik in der Beurteilung dieser Fragestellung überprüft. Dabei zeigte sich, daß nur die Kombination von Angiographie und Computertomographie eine Aussage zur Gefäßinfiltration mit einer Treffsicherheit von 90% ermöglicht. Lebermetastasen wurden retrospektiv in 80% und prospektiv in 66,7% (Sonographie) bzw. 58,3% (Computertomographie) bei einer Spezifität von 86,9% bzw. 91,3% erkannt. Diese Ergebnisse bestätigen das bisherige Therapiekonzept, daß nur bei fraglicher allgemeiner Operabilität eine ausgedehnte präoperative Diagnostik zur Beurteilung der lokalen Operabilität und Resektabilität notwendig ist.
    Notes: Summary The value of preoperative diagnostics in evaluating the extension of pancreatic carcinoma can be important in some cases for planning its therapy. In ca. 90% of our own patient material only the combination of angiography and computed tomography allowed a correct decision regarding tumor invasion of the vessels. Retrospectively metastases of the liver were seen in 80% and prospectively in 66.7% (sonography), respectively 58.3% (computed tomography) with a specifity of 86.9% respectively 91.3%. These results support our procedure of performing preoperative diagnostics in order to evaluate local operability and resectability only in patients with bad physical condition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00186118
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  • 2
    Electronic Resource
    Electronic Resource
    Ion transport across leech integument (1993)
    Springer
    Journal of comparative physiology 163 (1993), S. 153-159 
    Details
    ISSN: 1432-136X
    Keywords: Na+ channels ; Amiloride ; Benzamil ; Noise analysis ; Leech, Hirudo medicinalis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The dorsal skin of the leech Hirudo medicinalis was used for electrophysiological measurements performed in Ussing chambers. The leech skin is a tight epithelium (transepithelial resistance = 10.5±0.5 kΩ· cm-2) with an initial short-circuit current of 29.0±2.9 μA·cm-2. Removal of Na+ from the apical bath medium reduced short-circuit current about 55%. Ouabain (50μmol·l-1) added to the basolateral solution, depressed the short-circuit current completely. The Na+ current saturated at a concentration of 90 mmol Na+·l-1 in the apical solution (K M=11.2±1.8 mmol·l-1). Amiloride (100 μmol·l-1) on the apical side inhibited ca. 40% of the Na+ current and indicated the presence of Na+ channels. The dependence of Na+ current on the amiloride concentration followed Michaclis-Menten kinetics (K i=2.9±0.4 μmol·l-1). The amiloride analogue benzamil had a higher affinity to the Na+ channel (K i=0.7±0.2 μmol·l-1). Thus, Na+ channels in leech integument are less sensitive to amiloride than channels known from vertebrate epithelia. With 20 mmol Na+·l-1 in the mucosal solution the tissue showed an optimum amiloride-inhibitable current, and the amiloride-sensitive current under this condition was 86.8±2.3% of total short-circuit current. Higher Na+ concentrations lead to a decrease in amiloride-blockade short-circuit current. Sitmulation of the tissue with cyclic adenosine monophosphate (100 μmol·l-1) and isobutylmethylxanthine (1 mmol·l-1) nearly doubled short-circuit current and increased amiloride-sensitive Na+ currents by 50%. By current fluctuation analysis we estimated single Na+ channel current (2.7±0.9 pA) and Na+ channel density (3.6±0.6 channels·μm-2) under control conditions. After cyclic adenosine monophosphate stimulation Na+ channel density increased to 5.4±1.1 channels·μm-2, whereas single Na+ channel current showed no significant change (1.9±0.2 pA). These data present a detailed investigation of an invertebrate epithelial Na+ channel, and show the similarities and differences to vertebrate Na+ channels. Whereas the channel properties are different from the classical vertebrate Na+ channel, the regulation by cyclic adenosine monophosphate seems similar. Stimulation of Na+ uptake by cyclic adenosine monophosphate is mediated by an increasing number of Na+ channels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00263601
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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