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  • Electronic Resource  (26)
  • 1985-1989  (11)
  • 1980-1984  (7)
  • 1965-1969  (8)
  • 1
    Electronic Resource
    Electronic Resource
    Infrared spectral distribution of photoconductivity and up-conversion in GaP light emitting diodes (1985)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 57 (1985), S. 5438-5442 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The spectral distribution of photoconductivity and infrared excited electroluminescence has been determined in GaP light emitting diodes at low temperatures by conventional infrared spectroscopic techniques. The observed photoresponse was found to be caused by ionization of shallow donors only, showing a peak sensitivity of 20 mA/W at 13-μm wavelength. Spectral structures for photon energies lower than the binding energies of shallow donors are attributed to electric field assisted photoionization. An external quantum efficiency of 3×10−3 was obtained being largely independent on the bias voltage and the wavelength of infrared stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.334819
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  • 2
    Electronic Resource
    Electronic Resource
    Molecular Basis for Progestagen Therapy in Mammary Carcinoma (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 464 (1986), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1986.tb16060.x
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  • 3
    Electronic Resource
    Electronic Resource
    Permanent cure of hydroa vacciniforme after chemotherapy for Hodgkin's disease (1988)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 119 (1988), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1988.tb03485.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Palliative and adjunctive measures in rectal cancer (1982)
    Springer
    World journal of surgery 6 (1982), S. 569-577 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Cet article nous permet de relater notre expérience et celle de multiples auteurs en ce qui concerne les différentes méthodes thérapeutiques appliquées pour traiter le cancer du rectum: exérèse palliative, fulguration, cryo-chiruvgie, agents chimiques, encore qu'aucune étude comparative n'ait été entreprise pour apprécier leurs mérites respectifs. Dans notre série de 75 malades soumis à l'exérèse nous devons déploré une mortalité de 9,3%. Dans 88% des cas les symptomes présentés par le malade furent contrôlés cependant que la qualité de la vie fut satisfaisante jusqu'à leur décès. Le taux de la mortalité de la fulguration ne dépasse pas 0,5% mais les symptomes ne sont maitrisés que dans 40 à 80% des cas. Chez 219 malades soumis par nous mêmes à la cryo-chirurgie la mortalité fut de 2,3% cependant que le taux de la rémission atteignit 85%. La chimiothérapie a donné lieu à plusieurs études. D'après leurs données il semble que le cancer du rectum réponde mal aux différentes drogues cyto-toxiques qui ont été employées, le taux des rémissions s'étageant de 4 à 31% des cas traités.
    Notes: Abstract In this review we report our experience and that of others with palliative resection, fulguration, cryosurgery, and chemotherapy in rectal cancer. Since a trial has never been conducted to compare these procedures, it is not possible to give clear recommendations. In our study of palliative resection in 75 patients, we found an operative mortality of 9.3%. Tumor-related symptoms were controlled in 88%; the quality of life was good until death in most patients. Fulguration is reported to have a mortality rate of 0–5%, with control of symptoms in 40–80%, depending on tumor size. Cryosurgery was used in our series of 219 patients. Control of symptoms was achieved in 85% and the mortality rate was 2.3%. Side effects included unpleasant secretions for many weeks, bleeding, and stenoses. Chemotherapy has been tested in several studies. Colorectal cancer does not appear to be very sensitive to cytotoxic drugs, although numerous new substances have been tested over the past few years. Remissions have been achieved in 4–31% of patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01657871
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  • 5
    Electronic Resource
    Electronic Resource
    The clinical course of lung metastases from breast cancer (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 790-795 
    Details
    ISSN: 1432-1440
    Keywords: Breast cancer ; Lung metastases ; Clinical course
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clinical course of 50 breast cancer patients whose first metastases were found in the lungs was investigated. 18 months after the start of primary treatment 50% of the patients had developed pulmonary metastases (range: 0–81 months). In 23% of patients a solitary, and in 68% more than one, lung metastases were detected. After a median time of 4 months, in 56% of patients the disease had spread to further organs with bone (25%) and liver (17%) being the most frequent sites. First line management of lung metastases employed surgery, endocrine treatment, chemotherapy or a combination of these modalities. In 24% of patients a complete response was achieved, and in 11% a partial response, with an overall response rate of 35%. Median survival from detection of lung metastases was 13 months (range 4–123+). Patients with only a solitary lung metastasis survived for a median of 11.5 months as compared to 10.5 months for patients with more than one pulmonary metastases. Patients with a disease-free interval of more than 18 months survived significantly longer than patients with a disease-free survival of 18 months or less.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01726581
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  • 6
    Electronic Resource
    Electronic Resource
    Mucin-like cancer-associated antigen (MCA) compared with CA 15-3 in advanced breast cancer (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 813-817 
    Details
    ISSN: 1432-1440
    Keywords: Tumor marker ; MCA ; CA 15-3 ; Breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mucin-like cancer-associated antigen (MCA), a new tumor marker using the mouse monoclonal antibody b-12 is thought to be of value in the management of patients with breast cancer. In this study sera from 191 female patients with breast cancer (112 with progressive disease [PD] and 79 with no evidence of disease [NED]) were analyzed for MCA levels and compared with those of cancer antigen 15-3 (CA 15-3) in single determination and in combination with carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA). A cut-off level of 14 U/ml for MCA seems to be more appropriate than the recommended 11 U/ml to distinguish between PD and NED in patients with breast cancer. Although there was a fairly good correlation of MCA to CA 15-3, MCA was inferior in sensitivity and specificity to CA 15-3. Patients with osseous metastases and those with more than one metastatic site showed higher MCA levels than patients with visceral or soft tissue metastases, a fact which was comparable to CA 15-3. Combining MCA and CA 15-3 resulted in a gain in specificity but marked loss of sensitivity. The combination of MCA and CEA results also in a loss of sensitivity whereas the combination of CA 15-3 and CEA showed an increased specificity and only a negligible loss of sensitivity. The combination of MCA with TPA is of little value in the follow-up of breast cancer, as is the combination of CA 15-3 with TPA. The combination of CA 15-3 with CEA can be still recommended for follow-up for early detection of metastases in breast cancer. Further investigations with MCA to determine the lead time of this new marker as well as its role as a possible monitor of the response to therapy are recommended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01725197
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  • 7
    Electronic Resource
    Electronic Resource
    Ergebnisse der Österreichischen Ovarialkarzinomstudie (Stadien III und IV) (1985)
    Springer
    Archives of gynecology and obstetrics 238 (1985), S. 628-629 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02430141
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  • 8
    Electronic Resource
    Electronic Resource
    Acute cardiac toxicity in patients after doxorubicin treatment and the effect of combined tocopherol and nifedipine pretreatment (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 143-147 
    Details
    ISSN: 1432-1335
    Keywords: Doxorubicin ; Acute cardiac toxicity ; Prevention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In two groups of female patients with metastatic breast cancer who had all been pretreated with doxorubicin (350 mg/m2), acute cardiac effects following i.v. doxorubicin bolus injection (60 mg/m2) were recorded on the basis of systolic time intervals (STI). In six patients who received doxorubicin only the ratio between the heart-beat-corrected preejection period and left ventricular ejection time (PEPI:LVETI) as well as the PEP index were found to be significantly increased with a peak at 6 h following drug infusion (P〈0.001). Another six patients received an identical chemotherapeutic regimen and, in addition, a combination of tocopherol (200 mg i.m. 6 h before treatment) and nifedipine (60 mg p.o. daily from 2 days before doxorubicin infusion). In the pretreatment group, the PEPI: LVETI ration and PEP index remained unchanged during the posttreatment period. Pharmacokinetic analysis of drug concentrations in the plasma revealed a significantly accelerated distribution and elimination of doxorubicin after combined tocopherol and nifedipine pretreatment, although no statistically significant differences could be found in calculated drug levels in the peripheral compartment between both treatment groups. Our results indicate that acute cardiac reactions reflected by changes in STI values can be prevented by combined tocopherol and nifedipine pretreatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00395393
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  • 9
    Electronic Resource
    Electronic Resource
    Noninvasive methods for the early detection of doxorubicin-induced cardiomyopathy (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 136-142 
    Details
    ISSN: 1432-1335
    Keywords: Doxorubicin cardiomyopathy ; Systolic time intervals ; Radionuclide angiography ; Therapeutic risk
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ninety-eight female patients (mean age 54 years) who underwent doxorubicin therapy because of metastatic breast cancer were submitted to radionuclide angiography at rest. Left ventricular ejection fractions (LVEFs) were found to decrease significantly with the increasing cumulative doxorubicin dosage. Patients with prior local radiotherapy showed lower LVEFs at the same dosage level than nonirradiated patients, but the difference was not statistically significant. In a further study, 52 patients (mean age 56 years) were followed up regularly for their history and systolic time intervals prior to each doxorubicin treatment course. Before starting treatment, LVEF values were normal in all cases. Fifteen of these patients complained of dyspnea at some time during the treatment period before the critical cumulative dosage level of 550 mg/m2 was reached. Nine of these 15 patients showed an increase of the PEPI:LVETI ratio (≧0.40) and 12 patients a decrease of the LVEF values at rest at the same time. The rest of the patients did not complain of cardiac symptoms and did not show any significant alterations in systolic-time-interval measurements until the borderline dosage level (550 mg/m2) was attained. To evaluate myocardial function with greater accuracy, these 15 patients were submitted to right-heart catheterization and radionuclide angiography at rest and during exercise. As a result, doxorubiciri treatment had to be discontinued in three of these patients because of heart failure of stage III or IV and treatment with methyl digoxin and nifedipine was started. In these three patients cardiotonic medication could produce more or less complete cardiac recompensation. We conclude from our findings that signs of stage-III heart failure in radionuclide angiography performed while the patient is at rest and exercising should be regarded as the upper limit of the therapeutic risk, where further doxorubicin treatment is contraindicated. Cardiotonic medication during cytostatic courses should be avoided, however, because the true functional condition of the myocardium could be masked during a potentially cardiotoxic therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00395392
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  • 10
    Electronic Resource
    Electronic Resource
    Erythrozytenstoffwechsel vor und nach Splenektomie bei hereditärer Sphärozytose (1968)
    Springer
    Annals of hematology 17 (1968), S. 294-299 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Erythrocyte metabolism studies in a case with hereditary spherocytosis only showed minimal deviations of the activity of the enzymes of glycolysis from the normal values. The formation of lactate was increased, the intracellular sodium concentration was increased and the intracellular potassium concentration was decreased. The methemoglobin level of the erythrocytes was increased. After splenectomy, which resulted in a good clinical and hematological remission, lactate formation and the abnormal electrolyte and methemoglobin level of the erythrocytes returned to normal.
    Notes: Zusammenfassung Untersuchungen des Stoffwechsels der Erythrozyten bei einem Fall von hereditärer Sphärozytose ergaben nur geringe Abweichungen der Aktivität der Fermente der Glykolyse von der Norm. Die Bildung von Laktat war gesteigert, der Gehalt an intrazellulärem Natrium vermehrt und an Kalium vermindert; der Methämoglobingehalt der Erythrozyten war vermehrt. Nach der Splenektomie, die zu einer guten klinischen und hämatologischen Remission führte, normalisierte sich die Laktatbildung und der abnorme Elektrolytund Methämoglobingehalt der Erythrozyten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01631949
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