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  • Electronic Resource  (21)
  • 1985-1989  (15)
  • 1970-1974  (6)
  • 11
    Electronic Resource
    Electronic Resource
    A comparison of the haemodynamic effects of nifedipine, nisoldipine and nitrendipine in man (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 393-397 
    Details
    ISSN: 1432-1041
    Keywords: nifedipine ; nisoldipine ; nitrendipine ; haemodynamics ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Nifedipine (10 mg), nisoldipine (10 mg) and nitrendipine (20 mg) were given orally to 8 normal volunteers in a placebo controlled, double blind, crossover study. Blood pressure (BP), pulse (P) and systolic time intervals (STI) were recorded at time 0, 30, 60, 90, 120 min after drug administration. Adverse effects were also recorded. There was a fall in BP, pre-ejection time (PEP), PEP/LVET (left ventricular ejection time) and electro-mechanical systole index (QS2 index), and a rise in LVET index in response to the three active drugs compared with placebo. All active drugs, but not placebo, were associated with adverse effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607950
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  • 12
    Electronic Resource
    Electronic Resource
    Class experiment in clinical pharmacology with benzilonium bromide, an anticholinergic drug (1974)
    Springer
    European journal of clinical pharmacology 7 (1974), S. 141-143 
    Details
    ISSN: 1432-1041
    Keywords: Benzilonium bromide ; anticholinergic ; clinical pharmacology ; class experiment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a class experiment in clinical pharmacology, 12 pharmacy students demonstrated on themselves the anticholinergic effects of benzilonium bromide. Changes in salivary volume and heart rate showed differences in duration of action between two formulations of the drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561329
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  • 13
    Electronic Resource
    Electronic Resource
    A study of the influence of pH on the buccal absorption and renal excretion of procainamide (1974)
    Springer
    European journal of clinical pharmacology 7 (1974), S. 287-289 
    Details
    ISSN: 1432-1041
    Keywords: Procainamide ; buccal absorption ; renal excretion ; urine ; pH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The buccal absorption of procainamide was studied in 4 normal, male volunteers over a pH range of 5–11. In another investigation the same 4 volunteers collected their urine for 24 h after taking 250 mg of procainamide hydrochloride orally on 3 separate occasions, during which urine pH was uncontrolled, acidified by ammonium chloride ingestion or alkalinised by sodium bicarbonate ingestion. The procainamide remaining after buccal absorption and present in the urine samples was determined spectrophotometrically. It was found that neither the buccal absorption nor the renal excretion of procainamide was substantially altered by changes in pH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00560346
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  • 14
    Electronic Resource
    Electronic Resource
    The relationship between theophylline clearance and age in adult life (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 29-34 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; asthma ; clearance ; age ; adults ; elderly ; normal subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Fifty three subjects (31 normal volunteers and 22 patients with asthma) between the ages of 20 and 87 years had their theophylline clearance measured. Volume of distribution (V) and terminal elimination half-life (t1/2) were also calculated in the volunteers who received i.v. theophylline. Although patients tended to have higher clearance values than volunteers, in both groups the oldest third had the lowest clearances. For the combined group (corrected for the patient effect) the oldest third (mean age 70 years) had a mean clearance of 0.53 versus 0.72 for the middle third (mean age 47 years) and 0.73 ml/min/kg CBW for the youngest third (mean age 26 years). There was no statistically significant age related change in V/kg CBW but t1/2 did rise with increasing age. Thus, although clearance does not fall with increasing age during younger adult life, there is a fall during late adult life becoming apparent in the seventh, eighth and ninth decades.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561019
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  • 15
    Electronic Resource
    Electronic Resource
    Effect of captopril on skin blood flow following intradermal bradykinin measured by laser Doppler flowmetry (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 471-475 
    Details
    ISSN: 1432-1041
    Keywords: bradykinin ; captopril ; laser Doppler flowmetry ; weal ; flare ; skin blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of captopril on skin response to intradermal injection of bradykinin was investigated by laser Doppler flowmetry (LDF) and weal and flare measurements in this randomised, double-blind, placebo-controlled, cross-over balanced study. Intradermal injections of 1 and 2.5 µg of bradykinin and normal saline were made into the forearm skin of six healthy volunteers between 1 and 2 h (t1) and between 3 and 4 h (t2) after either 25 mg captopril or placebo. Skin blood flow outside the induced weal was monitored continuously by LDF for 15 min and the mean LDF values over the last 15 s were used for analysis. Weal and flare sizes were measured at 15 min. On the placebo days, the mean LDF output, weal volume and flare area increased with incremental bradykinin dose. Pre-treatment with captopril significantly increased LDF output following intradermal bradykinin at t1 but not at t2. At both t1 and t2, captopril significantly increased weal volume. There was no significant difference between treatments in flare areas. Skin response following intradermal normal saline, measured by the above parameters, was not affected by captopril. This study showed that captopril potentiated the effects of intradermal bradykinin both with respect to blood flow changes and weal formation. The non-invasive technique of LDF can be used to detect the skin blood flow changes induced by intradermal bradykinin and the potentiation of this effect by captopril. It appears to be a useful and more objective method of quantifying local cutaneous blood flow changes than measurement of flare area.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558126
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  • 16
    Electronic Resource
    Electronic Resource
    Flupirtine maleate and antipyrine half-life (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 437-437 
    Details
    ISSN: 1432-1041
    Keywords: Flupirtine maleate ; antipyrine ; half-life ; pharmaco kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637646
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  • 17
    Electronic Resource
    Electronic Resource
    Root squaring using level-index arithmetic (1989)
    Springer
    Computing 43 (1989), S. 171-185 
    Details
    ISSN: 1436-5057
    Keywords: 65G99 ; 65H05 ; Level-index ; symmetric level-index ; root-squaring ; polynomial equations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Das “symmetrische Höhenindexsystem” (sli) zur Zahlendarstellung vereinfacht die Überwachung der Rechengenauigkeit und vermeidet overflow—oder underflow—Probleme. In dieser Arbeit werden die praktischen Vorzüge des Systems am Beispiel des Graeffeverfahrens vorgeführt.
    Notes: Abstract The symmetric level-index,sli, system for representing numbers eases the monitoring of precision while avoiding the problems associated with overflow and underflow. In this paper the practical benefits of the system are displayed, using the root-squaring method of Graeffe as a vehicle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02241860
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  • 18
    Electronic Resource
    Electronic Resource
    Some rotifers from Republic of Korea (1986)
    Springer
    Hydrobiologia 137 (1986), S. 3-7 
    Details
    ISSN: 1573-5117
    Keywords: rotifers ; geographic distribution ; Republic of Korea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The author gives account of rotifers found at ten locations in the Republic of Korea, and elaborates some detail of specimens encountered with remarks and drawings. Thirty-seven different rotifer species were found, mostly belonging to the Order Monogononta. Twenty-two are new to the species list compiled by Yamamoto (1953). Keratella hiemalis was found for the first time in Asia. To date, one-hundred and two species of rotifers have been found in Korea.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00004166
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  • 19
    Electronic Resource
    Electronic Resource
    A new rotifer from a coastal lake in Southeastern Brazil: Hexarthra longicornicula n. sp. (1987)
    Springer
    Hydrobiologia 153 (1987), S. 169-174 
    Details
    ISSN: 1573-5117
    Keywords: rotifers ; taxonomy ; new species ; Neotropis ; Brazil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A new rotifer is described from among samples taken from coastal lakes in southeastern Brazil. Comparisons to related rotifers are made. This new animal belongs to the Hexarthra mira-intermedia species group by way of its general morphological configuration, the number of teeth in the trophi (5), and the two club-shaped caudal appendages (CSCA's). An extremely long dorsal antenna and very long setae extending from the bend in the ventro-lateral arm characterize this animal's speciation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00006648
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  • 20
    Electronic Resource
    Electronic Resource
    Quality factor of polycrystalline Nb between 0.4 and 10 K (1985)
    Springer
    Journal of low temperature physics 58 (1985), S. 37-45 
    Details
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The audiofrequency mechanical quality factor of niobium has been measured in the temperature regime 0.4–10 K. The results show that below 2 K the acoustic lossQ −1 reduces exponentially asT −1 → ∞. The data imply that the activation energy for thermally activated relaxation losses is finite atT=0 and that arbitrarily highQ factors may be achievable at very low temperatures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00682565
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