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  • Electronic Resource  (18)
  • 1985-1989  (18)
  • 11
    Electronic Resource
    Electronic Resource
    The oliC3 gene of Aspergillus niger: isolation, sequence and use as a selectable marker for transformation (1988)
    Springer
    Current genetics 14 (1988), S. 37-42 
    Details
    ISSN: 1432-0983
    Keywords: Aspergillus niger ; oliC ; Oligomycin resistance ; Transformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The oliC3 gene of Aspergillus niger has been isolated and sequenced. This gene encodes an oligomycinresistant variant of the mitochondrial ATP synthase subunit 9. In transformation experiments the gene can serve as a semi-dominant selectable marker for A. niger. It was possible to recognize transformants in which oliC3 had integrated at the homologous oliC locus, as opposed to elsewhere in the genome, by observation of phenotypes on medium containing oligomycin. DNA sequencing has allowed comparison of the deduced amino acid sequence with subunit 9 proteins from other species and comparison of 5′ untranslated sequences with those from other fungi.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00405851
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    Paper (German National Licenses)
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  • 12
    Electronic Resource
    Electronic Resource
    Origin of the anomalous 40 Ar— 39 Ar age of Zaire cubic diamonds: excess 40 Ar in pristine mantle fluids (1989)
    [s.l.] : Nature Publishing Group
    Nature 337 (1989), S. 226-229 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Cubic diamonds from Zaire show excellent correlations between potassium content and 40Ar/36Ar ratio, and between 40Ar/36Ar and 39Ar/36Ar, which can be interpreted to yield an 'isochron' age of about 6 Gyr. Now ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/337226a0
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    Paper (German National Licenses)
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  • 13
    Electronic Resource
    Electronic Resource
    Studies on glomerular basement membrane in experimental diabetes using lectin histochemistry in Wistar rats (1986)
    Springer
    Diabetologia 29 (1986), S. 495-499 
    Details
    ISSN: 1432-0428
    Keywords: Diabetic rats ; wheat germ agglutinin ; N-acetyl glucosamine ; glomerular basement membrane ; lectin histochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study was designed to establish whether specific early changes in carbohydrate content of proteins in the glomerulus of the diabetic rat could be detected. Lectin staining of kidney sections from streptozotocin-induced diabetic rats were compared with similar sections from healthy and diabetic rats that were treated with insulin. Animal groups were killed 1 month, 3 months and 6 months after induction of diabetes. There were no differences in the staining of the glomerular basement membrane between control, insulin-treated and diabetic rats for the lectins concanavalin A, lotus tetragonolobus, soybean and kidney bean, with and without trypsinisation. Staining of the glomerulur basement membrane with wheat germ agglutinin after trypsinisation was significantly increased in the diabetic group when compared to both healthy and insulin-treated groups (p 〈 0.01). It was concluded that, in experimental diabetes mellitus in the rat, there is an accumulation of substances in the glomerular basement membrane and mesangium with an affinity for wheat germ agglutinin, most probably N-acetyl glucosamine, and this is partially prevented by insulin treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00453500
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    Paper (German National Licenses)
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  • 14
    Electronic Resource
    Electronic Resource
    Further segregation analysis of the fragile X syndrome with special reference to transmitting males (1985)
    Springer
    Human genetics 〈Berlin〉 69 (1985), S. 289-299 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A new series of 96 pedigrees with the fra(X) syndrome was analysed using complex segregation analysis with pointers, defining affection as any degree of mental impairment. These families were found to exhibit the same segregation pattern as the first series of 110 pedigrees (Sherman et al. 1984). The best estimate for penetrance of mental impairment in males was 79% and in females was 35% for the combined data. Again, there was little evidence for sporadic cases among affected males. Many more intellectually normal transmitting males have been observed since the existence of such males and the concomitant need to investigate the paternal side of pedigrees was recognized. On further investigation of all 206 pedigrees from the old and new data sets, the sibships of nonexpressing males appeared to be different from those of expressing males. Our analysis, using mental impairment as the phenotype, suggested that obligate carrier mothers and daughters of intellectually normal transmitting males are rarely, if ever, mentally impaired and that the sibs of transmitting males are much less likely to be retarded than the sibs of mentally impaired males. Though mothers and daughters of transmitting males are similar in phenotype, the expression of the gene in their offspring appears to be different: the penetrance of mental impairment is higher in offspring of intellectually normal daughters of transmitting males than in offspring of intellectually normal mothers of transmitting males. The implications of these observations for genetic counseling and for genetic models of the fra(X) syndrome are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291644
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  • 15
    Electronic Resource
    Electronic Resource
    Multilocus analysis of the fragile X syndrome (1988)
    Springer
    Human genetics 〈Berlin〉 78 (1988), S. 201-205 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A multilocus analysis of the fragile X (fra(X)) syndrome was conducted with 147 families. Two proximal loci, DXS51 and F9, and two distal loci, DXS52 and DXS15, were studied. Overall, the best multipoint distances were found to be DXS51-F9, 6.9%, F9-fra(X), 22.4%; fra(X)-DXS52, 12.7%; DXS52-DXS15, 2.2%. These distances can be used for multipoint mapping of new probes, carrier testing and counseling of fra(X) families. Consistent with several previous studies, the families as a whole showed genetic heterogeneity for linkage between F9 and fra(X).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291662
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    Paper (German National Licenses)
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  • 16
    Electronic Resource
    Electronic Resource
    Erratum (1985)
    Springer
    Human genetics 〈Berlin〉 71 (1985), S. 184-186 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00283381
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    Paper (German National Licenses)
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  • 17
    Electronic Resource
    Electronic Resource
    Gene cloning in Aspergillus nidulans: isolation of the isocitrate lyase gene (acuD) (1986)
    Springer
    Molecular genetics and genomics 202 (1986), S. 271-275 
    Details
    ISSN: 1617-4623
    Keywords: Aspergillus ; Isocitrate lyase ; Cloning ; Recombinant DNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary An Aspergillus nidulans gene library was constructed in a high-frequency transformation vector, pDJB3, based on the Neurospora crassa pyr4 gene. This gene library was used to isolate the structural gene for isocitrate lyase (acuD) by complementation of a deficiency mutation following transformation of A. nidulans. Plasmids rescued in Escherichia coli were able to transform five different A. nidulans acuD mutants. Transformation using plasmids containing the cloned fragment resulted in integration at the acuD locus in six of nine transformants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00331649
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  • 18
    Electronic Resource
    Electronic Resource
    The growth and metastasis of four commonly used tumour lines implanted into eight different sites: Evidence for site and tumour effects (1988)
    Springer
    Clinical & experimental metastasis 6 (1988), S. 233-244 
    Details
    ISSN: 1573-7276
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The growth and metastasis of four commonly used experimental tumour lines have been compared after the implantation of cells into a lobe of the liver, the spleen, the left kidney, the peritoneal cavity, the thorax, the right thigh muscle, subcutaneously into the dorsolumbar region and intravenously into the tail vein or the right femoral vein. This was done to assess the importance of site in affecting metastatic distribution, and to determine whether any general conclusions could be drawn as to the role of this factor. Tumours grew at variable rates in different sites, but this did not affect the extent or distribution of metastasis. Each line gave a characteristic pattern that could be considerably modified by site. For example, in the spleen, metastasis was always extensively to the liver; in the kidney, and to some extent in the muscle, metastasis was similar to that obtained for intravenously injected cells; in the peritoneal cavity or thorax, metastasis was usually lower than from other sites; and in the liver, the metastasis to other lobes of the liver and to the lungs was modified. Many of these findings could be explained by both specific and non-specific factors operating at each site. It is suggested that interactions at the primary site of tumour growth may be very important in affecting metastasis, and that in the future more attention should be given to this factor in order to make progress in understanding tumour spread.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01782483
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    Paper (German National Licenses)
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