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  • 1
    Electronic Resource
    Electronic Resource
    The influence of imipramine on dopamine-induced ganglionic inhibition and neurogenic vasodilatation in the dog (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 286 (1975), S. 429-436 
    Details
    ISSN: 1432-1912
    Keywords: Dopamine ; Ganglionic Inhibition ; Neurogenic Vasodilatation ; Imipramine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Imipramine potentiates the dopamine-induced inhibition in the paravertebral lumbar ganglia of the dog. Potentiation by imipramine of the dopamine-induced neurogenic vasodilatation in the isolated perfused gracilis muscle, is seen in cross-circulation preparations only, where imipramine cannot reach the perfused vasculature. On the other hand, when imipramine is injected into the perfusion circuit of an isolated perfused gracilis muscle, it antagonizes the dopamine-induced neurogenic vasodilatation. When imipramine is injected intravenously into a dog with an autoperfused gracilis muscle, the peripheral antagonism masks the potentiating effect at the ganglionic level, and the dopamine-induced neurogenic vasodilatation is abolished.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00506656
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  • 2
    Electronic Resource
    Electronic Resource
    Plasma protein binding of phenylbutazone during recovery from acute renal failure (1975)
    Springer
    European journal of clinical pharmacology 9 (1975), S. 69-71 
    Details
    ISSN: 1432-1041
    Keywords: plasma protein binding ; phenylbutazone ; renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma protein binding capacity for phenylbutazone has been studied in 4 patients with acute renal failure. There was an initial important decrease in binding capacity, which gradually returned to normal with improvement of renal function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613431
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Plasma theophylline level and effect on lung function after oral and rectal administration of aminophylline (1979)
    Springer
    European journal of clinical pharmacology 15 (1979), S. 401-406 
    Details
    ISSN: 1432-1041
    Keywords: aminophylline ; bronchodilatation ; lung function ; plasma concentrations ; theophylline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twelve patients with partly reversible, chronic airway obstruction, according to a double blind randomized cross-over design, received on three consecutive days oral aminophylline 500 mg, a 500 mg aminophylline suppository and a placebo. The effects on ventilatory function were studied and the plasma concentration of theophylline was measured. After rectal administration, the plasma concentration of theophylline rose to 5 to 10 µg/ml, and after oral ingestion the plasma level in most patients exceeded 10 µg/ml. Administration of the aminophylline suppository resulted in moderate improvement in ventilatory function, and although the improvement was less pronounced than after oral administration, the use of a suppository in the treatment of patients with chronic obstructive lung disease should not be rejected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561738
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of acute renal failure on the protein binding of drugs in animals and in man (1977)
    Springer
    European journal of clinical pharmacology 11 (1977), S. 27-32 
    Details
    ISSN: 1432-1041
    Keywords: Protein binding ; acute renal failure ; phenylbutazone ; warfarin ; papaverine ; quinidine ; digitoxin ; comparative study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Serum protein binding of phenylbutazone has been measured in the rat, guinea pig, cat, rabbit and dog, and the influence on it of renal failure induced by uranyl nitrate injection has been studied. In all species a clearcut decrease in binding was observed after the occurrence of renal failure; the time course of the fall in binding correlated well with development of renal failure. In further experiments, serum protein binding of two acidic drugs (phenylbutazone, warfarin), two basic drugs (papaverine, quinidine) and one neutral drug (digitoxin) was studied in rabbits with experimental renal failure, and the results compared with those obtained in patients with acute renal failure. In the rabbits, a decrease in the binding of phenylbutazone, warfarin, papaverine and quinidine was found, whereas protein binding of digitoxin was unchanged. In man, there was a definite fall in protein binding of phenylbutazone and digitoxin, a small decrease for warfarin and papaverine, and a slight increase for quinidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561784
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of beta-adrenergic blockade on blood pressure variation in patients with moderate hypertension (1977)
    Springer
    European journal of clinical pharmacology 11 (1977), S. 325-327 
    Details
    ISSN: 1432-1041
    Keywords: Hypertension ; Variability ; Beta-blockade ; Atenolol ; Arteriosonde
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of beta-adrenergic blockade on blood pressure variation was studied in ten patients with moderate hypertension. Supine systolic and diastolic blood pressures were measured every 5 min during six hours sessions, using an ultrasonic method. Systolic and diastolic variation in each six hour session was defined as the standard deviation of the mean of systolic and diastolic readings made in that period. After 3 weeks of single-blind placebo, a 12 week double-blind randomized crossover study was initiated with placebo (6 weeks) and atenolol (100 mg b. i. d. for 3 weeks and 200 mg b. i. d. for 3 weeks). Systolic and diastolic blood pressure and heart rate decreased significantly (p〈0.01) during atenolol treatment. Diastolic variation did not change significantly, whereas systolic variation decreased slightly but significantly (p〈0.05) when expressed in absolute values, but not when expressed as a percentage of systolic blood pressure. It is concluded that beta-adrenergic blockade decreases blood pressure and heart rate without causing significant changes in spontaneous systolic or diastolic variation
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00566528
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  • 6
    Electronic Resource
    Electronic Resource
    Dopamine-induced neurogenic vasodilatation in isolated perfused muscle preparation of the dog (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 286 (1975), S. 413-428 
    Details
    ISSN: 1432-1912
    Keywords: Dopamine ; (-)-Noradrenaline ; Neurogenic Vasodilatation ; Ganglionic Inhibition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Dopamine, injected into the lumbar aorta of the dog in doses which produce a reversible inhibition of synaptic transmission in the lumbar paravertebral ganglia (0.5–64×10−8 moles), produces a neurogenic vasodilatation in the isolated perfused hindleg or gracilis muscle. This was abolished by acute preganglionic decentralization and by administration into the perfused preparation of α-adrenoceptor blocking agents, but not of atropine or diphenhydramine. After decentralization, preganglionic electrical stimulation restored the dopamine-induced indirect vasodilatation. The neurogenic vasodilatation was also seen with intra-aortic injections of epinine (2–32×10−8 moles) and apomorphine (1.2–19.2×10−8 moles) and was preferentially blocked by haloperidol (0.26×10−6 moles). (-)-Noradrenaline, injected into the lumbar aorta in baroreceptor-denervated dogs, was found to be equipotent with dopamine in eliciting the neurogenic vasodilatation; this (-)-noradrenaline-induced effect was preferentially blocked by phentolamine (8×10−6 moles). The possibility that the neurogenic vasodilatation, which occurs upon intra-aortic injection of dopamine in the dog, is due to its ganglionic-inhibitory effect is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00506655
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  • 7
    Electronic Resource
    Electronic Resource
    Quantitative GLC determination of the cis- and trans-isomers of doxepin and desmethyldoxepin in human plasma (1978)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 290 (1978), S. 158-158 
    Details
    ISSN: 1618-2650
    Keywords: Best. von Doxepin, Desmethyldoxepin in Plasma ; Chromatographie, Gas ; cis-trans-Isomere
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00482315
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