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  • Digitale Medien  (5)
  • Duck  (3)
  • A cell  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Effect of insulin on glucagon secretion mediated via glucose metabolism of pancreatic a cells in ducks (1981)
    Springer
    Diabetologia 20 (1981), S. 72-77 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Glucose ; insulin ; glucagon ; glucose metabolism ; A cell ; 2-deoxyglucose ; subtotal pancreatectomy ; ducks
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A possible action of insulin via glucose metabolism on the pancreatic A cell response to glucose, was studied in ducks. 2-Deoxyglucose, a non metabolizable analogue of glucose was used. In normal ducks, the hyperglycaemia induced by 2-deoxyglucose (IV: 0.5g/kg) resulted in hyper glucagonaemia, while the same degree of hyper glycaemia, induced by glucose infusion (IV injection 25 mg/kg, and infusion 5 mg/kg/min) immediately suppressed glucagon secretion. In diabetic ducks, two days after subtotal pancreatectomy, glucose responsiveness of the A cell was abolished, but could be restored by insulin treatment before (IM 0.2 U/kg insulin + 8 μg/kg glucagon every 6 h) and during (IV 3.6 mU/kg + infusion 0.9 mU/kg/min) the glucose test (IV: 0.5 g /kg). The normal response of the A cell to glucose was not observed in diabetic insulintreated ducks after the administration of 2-deoxyglucose (IV: 0.5 g/kg). These data suggest an inhibitory effect of the metabolism of glucose on the release of glucagon. In addition, the action of insulin on the A cell may be mediated by its effect on glucose metabolism within the A cell.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00253821
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  • 2
    Digitale Medien
    Digitale Medien
    Somatostatin stimulates glucagon secretion in ducks (1980)
    Springer
    Diabetologia 18 (1980), S. 319-322 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Duck ; somatostatin ; glucagon-like immunoreactivity ; insulin growth hormone ; glucose
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In normal fasting ducks, a somatostatin infusion (800 ng/kg/min for 30 min) elicited a prompt inhibition of insulin secretion, plasma levels falling from 140±20 to 20±6 pg Eq/ml as observed in mammals. — However plasma glucagon-like-immunoreactivity shown to be decreased in mammals by somatostatin was sharply increased from a mean basal level of 1.46±0.13 ng Eq/ml to 6.61±0.77 ng Eq/ml. This effect was not mediated via inhibition of growth hormone secretion since it was also observed in hypophysectomised ducks. Despite the fall in plasma insulin and rise in GLI observed with somatostatin infusion in intact birds, plasma glucose concentrations were lower than with control saline infusion.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00251013
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  • 3
    Digitale Medien
    Digitale Medien
    Roles of insulin and glucose in the regulation of plasma FFA in the duck (1978)
    Springer
    Diabetologia 14 (1978), S. 185-190 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Duck ; adipose tissue ; FFA release ; glucagon ; insulin ; glucose uptake
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The present study was undertaken to determine how free fatty acid (FFA) release by adipose tissue can occur in the absence of pancreatic glucagon, the most potent lipolytic hormone in the duck. Two possible explanations have successively been investigated. Replacement therapy experiments showed that glucose uptake was implicated in the phenomenon; indeed, when pre-operative insulin and glucose levels were restored after total pancreatectomy, plasma FFA progressively fell to a level significantly lower than the pre-operative value. The same effect was observed when the ducks were kept in a continuous state of hyperglycaemia, whereas “normal” levels of insulin or glucose alone were shown to be ineffective. On the other hand a compensatory mechanism for the lack of glucagon, by other lipolytic agents [with the intestine or the anterior pituitary as possible sources] has been excluded by associating the removal of these two organs with pancreatectomy. These experiments suggest that the lack of pancreatic glucagon induced by total pancreatectomy is essentially masked by a failure in glucose uptake due to the operation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00429779
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  • 4
    Digitale Medien
    Digitale Medien
    Effect of insulin on glucagon secretion mediated via glucose metabolism of pancreatic A cells in ducks (1981)
    Springer
    Diabetologia 21 (1981), S. 72-77 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Glucose ; insulin ; glucagon ; glucose metabolism ; A cell ; 2-deoxyglucose ; subtotal pancreatectomy ; ducks
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A possible action of insulin via glucose metabolism on the pancreatic A cell response to glucose, was studied in ducks. 2-Deoxyglucose, a non-metabolizable analogue of glucose was used. In normal ducks, the hyperglycaemia induced by 2-deoxyglucose (IV: 0.5 g/kg) resulted in hyperglucagonaemia, while the same degree of hyperglycaemia, induced by glucose infusion (IV injection 25 mg/kg, and infusion 5 mg/kg/min) immediately suppressed glucagon secretion. In diabetic ducks, two days after subtotal pancreatectomy, glucose responsiveness of the A cell was abolished, but could be restored by insulin treatment before (IM 0.2 U/kg insulin+8 μg/kg glucagon every 6 h) and during (IV 3.6 mU/kg+infusion 0.9 mU/kg/min) the glucose test (IV: 0.5 g /kg). The normal response of the A cell to glucose was not observed in diabetic insulin-treated ducks after the administration of 2-deoxyglucose (IV: 0.5 g/kg). These data suggest an inhibitory effect of the metabolism of glucose on the release of glucagon. In addition, the action of insulin on the A cell may be mediated by its effect on glucose metabolism within the A cell.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01789118
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  • 5
    Digitale Medien
    Digitale Medien
    Insulin and the glucose-glucagon feedback mechanism in the duck (1976)
    Springer
    Diabetologia 12 (1976), S. 23-33 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Duck ; glucose-glucagon feedback mechanism ; glucagon ; insulin ; glucose
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The relationship between insulin and the glucose-glucagon feedback mechanism was studied by testing the effectiveness of various routes, doses and timing of insulin administration prior to and during a glucose tolerance test in Peking ducks made transiently diabetic by subtotal pancreatectomy. Insulin injections or infusions given either before, or only during the glucose load, did not restore the A-cell response to glucose. Yet, if given both before and during the glucose test, in conditions which mimic the physiological basal insulin level and its variations (with, initially, intramuscular injections of 0.2 IU/kg and 8 μg/kg glucagon, every six hours, and then an intravenous injection of 3.6 mU/kg plus an infusion of 0.9 mU/kg/ minute for one hour), the normal glucagon response to glucose was re-established. Insulin must therefore be present, both before and during glucose stimulation, for glucose to be effective as an A-cell suppressor.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01221961
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