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  • Electronic Resource  (2)
  • Acenaphthene 1,2-imine  (1)
  • Femoral fractures  (1)
  • 1
    ISSN: 1433-044X
    Keywords: Schlüsselwörter Retrograde Femurmarknagelung ; Minimalinvasive Implantatentfernung ; Korrekturosteotomie ; Marknagel ; Keywords Retrograde femoral nailing ; Arthroscopic assisted implant removal ; Femoral fractures ; Supracondylar osteotomies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Recently, the retrograde femoral nailing has become a procedure with increasing acceptance. Indications for the retrograde femur nail are distal femoral fractures including dia- and transcondylar fractures, supracondylar osteotomies and distal periprosthetic femur fractures after total knee joint replacement. Controversial discussion is carried on about the implant removal, which is potentially afflicted with further damage to the knee joint. To minimise the operative damage due to the implant removal, an arthroscopic assisted procedure has been selected. The arthroscopic assisted implant removal was possible in all of our patients. Intraoperatively, 2/3 of the patients showed normal age-related findings of the chondral and meniscal structures. The arthroscopic assisted implant removal is a gentle procedure, which allows minimal invasive extraction of retrograde femur nails and prevents secondary damage to the knee joint due to the otherwise difficult localisation of the implant. The advantages of this procedure concerning gentleness and diagnostic capabilities are as convincing, that we indicate implant removal of retrograde femur nails in all younger patients (〈60 years), except in periprosthetic fractures.
    Notes: Zusammenfassung Die distale Femurmarknagelung ist in den letzten Jahren ein zunehmend gängiges Verfahren geworden. Die Hauptindikationsgebiete der retrograden Femurmarknagelung sind die distalen Femurfrakturen einschließlich der dia- und perkondylären Gelenkfrakturen des distalen Femur, Korrekturosteotomien und periprothetische distale Femurfrakturen nach Kniegelenkimplantation. In der Diskussion ist die Implantatentfernung, welche zu einem erneuten Schaden im Bereich des Kniegelenkes führt. Um den operativen Schaden der Implantatentfernung zu minimieren, wurde eine arthroskopisch gestützte Vorgehensweise gewählt. Die arthroskopisch unterstützte Metallentfernung war bei allen Patienten möglich. Intraoperativ konnten arthroskopisch bei 2/3 der Fälle unauffällige Gelenkverhältnisse gefunden werden. Die arthroskopisch gestützte Entfernung retrograder Marknägel ist eine schonende Vorgehensweise, welche die minimal-invasive Entfernung retrograder Marknägel ermöglicht und dabei mit Hilfe der arthroskopischen Sicht sekundäre Schäden im Bereich des Knies durch schwieriges Aufsuchen des Nageleintritts verhindert. Dieses Verfahren ist so schonend bei der Entfernung retrograder Marknägel des distalen Femur, dass wir die Metallentfernung – mit Ausnahme von periprothetischen Frakturen – bei jüngeren Patienten (〈60 Jahre) für indiziert halten.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0738
    Keywords: cis- and trans-stilbene imine ; cis- and trans-stilbene oxide ; Acenaphthene 1,2-imine ; Drug-metabolizing enzymes ; Mutagenicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract trans-Stilbene imine (trans-1,2-diphenylaziridine) is the nitrogen analog of trans-stilbene oxide, a potent inducer of several microsomal and cytosolic xenobiotic-metabolizing enzymes. Although the acute toxicity of cis- and trans-stilbene imines prevents their application at the usual dose for trans-stilbene oxide (400 mg/kg/day), it is apparent that the imines nevertheless potently induce several xenobiotic-metabolizing enzymes in rat liver. The IP administration of trans-stilbene imine resulted in statistically significant increases in the activities of aminopyrine N-demethylase, microsomal epoxide hydrolase, glutathione transferase (toward 1-chloro-2,4-dinitrobenzene, 1,2-dichloro-4-nitrobenzene and Δ5-androstene-3,17-dione) and UDP-glucuronosyltransferase (toward testoster-one). cis-Stilbene imine was less potent in inducing these activities. Although trans-stilbene imine (total dose = 400 mg/kg) was more potent than trans-stilbene oxide (total dose = 1200 mg/kg) in inducing the activities of glutathione transferase (toward 1-chloro-2,4-dinitrobenzene) and UDP-glucuronosyltransferase (toward testosterone), both compounds belong to the class of substances which are more potent inducers of conjugating (phase II) enzymes. Because of their structural similarity with K-region arene imines which are potent mutagens, cis-stilbene imine and trans-stilbene imine were investigated for mutagenicity (reversion of his − strains of Salmonella typhimurium). cis-Stilbene imine and trans-stilbene imine were direct mutagens in the strain TA100. This result, and the finding that acenaphthene 1,2-imine efficiently reverts various strains of Salmonella typhimurium, demonstrates that not only K-region arene imines, but also other aziridines substituted at the two carbons with aromatic moieties, are mutagenic.
    Type of Medium: Electronic Resource
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