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  • Digitale Medien  (9)
  • Rats  (5)
  • Annonaceae  (4)
  • 1
    Digitale Medien
    Digitale Medien
    Central pharmacological control of corticosterone secretion in the intact rat. demonstration of cholinergic and serotoninergic facilitatory and α-adrenergic inhibitory mechanisms (1980)
    Springer
    Psychopharmacology 71 (1980), S. 213-217 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Corticosterone ; Muscarinic agonists ; Serotoninergic agonists ; α-Adrenoceptor agonists ; Rats
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A method is described for demonstrating the hypothalamic control of corticosterone in the intact rat. Oxotremorine 0.01–0.05 mg/kg IP and 5-hydroxy-l-tryptophan 1–50 mg/kg IP raise plasma corticosterone levels in dose-related fashion. The oxotremorine response is blocked by atropine 1 mg/kg SC and the 5-hydroxy-l-tryptophan response by mianserin 10 mg/kg IP. α-Methylparatyrosine methyl ester 400 mg/kg IP raises plasma corticosterone levels 14–16 h later. This rise can be suppressed by clonidine 0.01–0.05 mg/kg IP and this suppression is antogonized by piperoxane 5–50 mg/kg IP. Apomorphine 5 mg/kg IP does not lower plasma corticosterone levels in rats pre-treated with α-methylparatyrosine. The response to oxotremorine cannot be blocked by atropine methylbromide or by mianserin. The response to 5-hydroxy-l-tryptophan is unaffected by benserazide or atropine sulphate. These data suggest separate cholinergic and serotoninergic facilitation of corticosterone release in the intact rat. The stimulating drugs used appear to be acting centrally. The data also support the presence of a noradrenergic inhibitory system mediated by α-adrenoceptors. Dopaminergic receptors appear to play no part in the central control of corticosterone secretion after pre-treatment with α-methylparatyrosine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00433054
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  • 2
    Digitale Medien
    Digitale Medien
    Leucocyte values in rats and mice following carbon dioxide euthanasia (1991)
    Springer
    Comparative clinical pathology 1 (1991), S. 233-235 
    Details
    ISSN: 1433-2981
    Schlagwort(e): Carbon dioxide ; Euthanasia ; Leucocytes ; Mice ; Rats
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Leucocyte counts obtained from Wistar rats and CD1 mice following euthanasia with carbon dioxide were compared to leucocyte values obtained using other agents for anaesthesia or euthanasia. In rats, following euthanasia with carbon dioxide, lymphocyte and neutrophil counts in samples taken from the heart were significantly raised compared with sodium barbiturate euthanasia. In mice, following carbon dioxide, total leucocyte counts from brachial plexus were significantly lower than other collection sites. Lymphocyte counts from vena cava and brachial plexus were also significantly lower than other sites.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00235378
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  • 3
    Digitale Medien
    Digitale Medien
    Preliminary studies with an SLS method for haemoglobin determination in three species (1992)
    Springer
    Comparative clinical pathology 2 (1992), S. 101-102 
    Details
    ISSN: 1433-2981
    Schlagwort(e): Haemoglobinometry ; Sodium lauryl sulphate ; Rats ; Dogs ; Mice
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A commercially available sodium lauryl sulphate reagent was used to determine haemoglobin values in three species, and these values were compared with results obtained by a cyanmethaemoglobin method with the same haematology analyser. Correlation of the two methods was satisfactory for samples obtained from healthy rats and dogs. For mouse samples, the correlation between methods was poorer than for the other two species.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00186269
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  • 4
    Digitale Medien
    Digitale Medien
    Gigantecin: A novel antimitotic and cytotoxic acetogenin, with nonadjacent tetrahydrofuran rings, fromGoniothalamus giganteus (Annonaceae) (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 539-541 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Gigantecin ; acetogenins ; Goniothalamus giganteus ; Annonaceae ; brine shrimp ; antimitotic ; cytotoxic ; crown gall tumors ; potato disc assay ; 9 ASK
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Gigantecin (I), a novel tetrahydroxy-di-tetrahydrofuran fatty acid γ-lactone (acetogenin), was isolated from an ethanolic extract of the stem bark ofGoniothalamus giganteus Hook. f., Thomas (Annonaceae), by means of activity-directed fractionation (brine shrimp lethality test). This new compound is extremely cytotoxic to human tumor cells, inhibits crown gall tumors on potato discs, and is active in an assay designed to detect antimitotic agents (9 ASK).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01954260
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  • 5
    Digitale Medien
    Digitale Medien
    Goniothalamicin and annonacin: Bioactive acetogenins fromGoniothalamus giganteus (Annonaceae) (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 83-85 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Goniothalamicin ; annonacin ; acetogenins ; Goniothalamus giganteus ; Annonaceae ; brine shrimp ; insecticidal ; cytotoxic ; antileukemic activity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Using brine shrimp lethality for activity-directed fractionation, goniothalamicin (I), a new tetrahydroxy-mono-tetrahydrofuran fatty acid γ-lactone (acetogenin), has been isolated from ethanolic extracts of the stem bark ofGoniothalamus giganteus Hook. f., Thomas (Annonaceae). This novel compound was found to be cytotoxic and insecticidal and inhibited the formation of crown gall tumors on potato discs. Annonacin (II), the only other reported mono-tetrahydrofuran acetogenin, was also isolated; the previously reported 9ASK (astrocytoma reversal) activity ofII was confirmed, andII is now also found to be weakly active against 3PS murine leukemia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01960258
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  • 6
    Digitale Medien
    Digitale Medien
    Sylvaticin: A new cytotoxic and insecticidal acetogenin fromRollinia sylvatica (Annonaceae) (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 324-327 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Sylvaticin ; acetogenin ; Rollinia sylvatica ; Annonaceae ; brine shrimp ; cytotoxicity ; insecticidal ; striped cucumber beetle ; European corn borer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Sylvaticin (I), a new tetrahydroxy annonaceous acetogenin with nonadjacent tetrahydrofuran rings, has been isolated from the dried fruits ofRollinia sylvatica St. Hil. (Annonaceae). This compound is extremely cytotoxic to human tumor cells and shows promising insect control properties.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01951779
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  • 7
    Digitale Medien
    Digitale Medien
    Annonacin, a novel, biologically active polyketide fromAnnona densicoma (1987)
    Springer
    Cellular and molecular life sciences 43 (1987), S. 947-949 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Annonacin ; polyketide ; Annona densicoma ; Annonaceae ; biological activity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary A new linear polyketide, Annonacin (I), has been isolated from active extracts of the stembark ofAnnona densicoma Mart. Annonacin (I) is highly cytotoxic and is active in an assay designed to detect antimitotic agents. The structure of (I) was determined by analysis of spectroscopic data.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01951681
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  • 8
    Digitale Medien
    Digitale Medien
    The effect of repeated electroconvulsive shocks on growth hormone secretion and growth hormone responses to clonidine in the intact rat (1982)
    Springer
    Psychopharmacology 76 (1982), S. 98-100 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Electroconvulsive shock ; Growth hormone ; Clonidine ; Rats
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effect of repeated electroconvulsive shocks (ECS) on growth hormone (GH) secretion was studied in rats. Male Sprague-Dawley animals were given one ECS daily for 10 days under halothane anaesthesia. Control animals were anaesthetised only. GH secretion was studied 24 h after the last ECS or sham procedure. Background GH secretion was significantly greater in ECS-treated than in sham-treated animals (P〈0.001). The GH response to IV clonidine (0.01–0.1 mg/kg) did not differ between the two groups. The size of the GH response was not directly related to the basal GH secretion and could not be explained in terms of it.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00430767
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  • 9
    Digitale Medien
    Digitale Medien
    The effect of repeated electroconvulsive shock on corticosterone responses to centrally acting pharmacological stimuli in the male rat (1980)
    Springer
    Psychopharmacology 71 (1980), S. 205-212 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Electroconvulsive shock ; Corticosterone ; Muscarinic agonists ; Serotoninergic agonists ; α-Adrenoceptor agonists ; Rats
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effect of repeated and single electroconvulsive shocks (ECS) on the corticosterone response to pharmacological stimuli has been studied in male rats. Plasma corticosterone concentrations are elevated by oxotremorine, a muscarinic agonist, and by 5-hydroxy-l-tryptophan, a precursor of serotonin. Both these agonists probably stimulate corticotrophinreleasing-factor release from the hypothalamus. The log dose-response curves of the corticosterone response to oxotremorine and to 5-hydroxy-l-tryptophan are shifted to the left after a single ECS given daily for 10 days compared with sham-shocked controls. Plasma corticosterone concentrations are elevated by treatment with α-methyl-p-tyrosine methyl ester (400 mg/kg IP). This rise is suppressed by clonidine. The log dose-response curve for the corticosterone response to clonidine after α-methyl-p-tyrosine methyl ester is also shifted to the left by repeated ECS, compared with controls. There is no difference in the corticosterone response of ECS and sham-treated groups given vasopressin, which is thought to act directly on the pituitary to release ACTH. A single ECS produces a slight enhancement of the response to 5-hydroxy-l-tryptophan, a slight decrease in the response to oxotremorine and no change in the response to clonidine after α-methyl-p-tyrosine. The disappearance of the difference in response between ECS and sham-treated animals was also studied 1,3, and 6 days after a series of ten ECS or sham procedures. Significant differences in the corticosterone responses to oxotremorine, 5-hydroxy-l-tryptophan and clonidine after α-methyl-p-tyrosine between ECS and sham-treated animas were found 24 h after the last ECS or sham shock. These differences were in decline 3 days after the last procedure and had completely disappeared by day 6. The decline was largely due to an increase in plasma corticosterone responsiveness to pharmacological stimuli of the shamshocked controls. Responses in the ECS-treated groups remained constant. It is apparent that the anaesthetic procedure suppresses the effect of oxotremorine, 5-hydroxy-l-tryptophan and clonidine after α-methyl-p-tyrosine on corticosterone concentrations in plasma. This effect is spontaneously reversible. Repeated ECS reverses the effect of the anaesthetic procedure but produces no reversible enhancement of its own.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00433053
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