Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Electronic Resource  (4)
  • Down's syndrome  (2)
  • Oligodendrocyte  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Microglial cells and amyloid β protein (Aβ) deposition: association with Aβ40-containing plaques (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 472-477 
    Details
    ISSN: 1432-0533
    Keywords: Key words Microglial cells ; Amyloid β protein ; Monoclonal antibodies ; Down's syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two distinct species of amyloid β protein (Aβ) with different carboxyl termini, Aβ40 and Aβ42(43), are deposited in plaques in the brains of patients with Alzheimer's disease and Down's syndrome. The relationship between these two forms of Aβ and microglial cells was investigated in 16 subjects with Down's syndrome ranging in age from 31 to 64 years. The amount of Aβ40 in plaques was low in persons under 50 years of age, even though high amounts of Aβ42(43) were present, but this former species increased after this age. Microglia were observed most commonly in plaques containing both Aβ40 and Aβ42(43) but less commonly in those with Aβ42(43) alone. The presence of microglial cells in plaques may be associated with the accumulation of Aβ40 and these cells may have a role in the production or processing of this particular molecular species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294808
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 129-136 
    Details
    ISSN: 1432-0533
    Keywords: Key words: Neurofibrillary tangle ; Tau ; Phosphorylation ; Astrocyte ; Oligodendrocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tau accumulating as paired helical filaments (PHF) in Alzheimer's disease brain is considered to be abnormally phosphorylated on distinct sites. To compare the phosphorylation state of tau-positive neuronal inclusions among diverse neurologic diseases, we have probed these lesions with three well-defined PHF/tau monoclonals, C5, M4 and tau 1, that most likely recognize three proline-directed phosphorylation sites in PHF-tau. In Alzheimer's disease brain all three monoclonals intensely immunostained intracellular neurofibrillary tangles, neuropil threads, senile plaque neurites, and “pretangle neurons” in a phosphorylation-dependent manner. They also stained, in the same manner, Pick bodies in Pick's disease, and neurofibrillary tangles and neuropil threads in various tangle-forming neurologic diseases. In most of these diseases (including Pick's disease, progressive supranuclear palsy, subacute sclerosing panencephalitis, and Alzheimer's disease) astrocytes and oligodendrocytes were found to contain tau-positive inclusions which showed the same immunocytochemical characteristics. Thus, the widely occurring tau-positive inclusions share common phosphorylation characteristics irrespective of underlying diseases or cell types.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294505
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Microglial cells and amyloid β protein (Aβ) deposition: association with Aβ40-plaques (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 472-477 
    Details
    ISSN: 1432-0533
    Keywords: Microglial cells ; Amyloid β protein ; Mohoclonal antibodies ; Down's syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two distinct species of amyloid β protein (Aβ) with different carboxyl termini, Aβ40 and Aβ42(43), are deposited in plaques in the brains of patients with Alzheimer's disease and Down's syndrome. The relationship between these two forms of Aβ and microglial cells was investigated in 16 subjects with Down's syndrome ranging in age from 31 to 64 years. The amount of Aβ40 in plaques was low in persons under 50 years of age, even though high amounts of Aβ42(43) were present, but this former species increased after this age. Microglia were observed most commonly in plaques containing both Aβ40 and Aβ42(43) but less commonly in those with Aβ42(43) alone. The presence of microglial cells in plaques may be associated with the accumulation of Aβ40 and these cells may have a role in the production or processing of this particular molecular species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294808
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 129-136 
    Details
    ISSN: 1432-0533
    Keywords: Neurofibrillary tangle ; Tau ; Phosphorylation ; Astrocyte ; Oligodendrocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tau accumulating as paired helical filaments (PHF) in Alzheimer's disease brain is considered to be abnormally phosphorylated on distinct sites. To compare the phosphorylation state of tau-positive neuronal inclusions among diverse neurologic diseases, we have probed these lesions with three well-defined PHF/tau monoclonals, C5, M4 and tau 1, that most likely recognize three proline-directed phosphorylation sites in PHF-tau. In Alzheimer's disease brain all three monoclonals intensely immunostained intracellular neurofibrillary tangles, neuropil threads, senile plaque neurites, and “pretangle neurons” in a phosphorylation-dependent manner. They also stained, in the same manner, Pick bodies in Pick's disease, and neurofibrillary tangles and neuropil threads in various tangle-forming neurologic diseases. In most of these diseases (including Pick's disease, progressive supranuclear palsy, subacute sclerosing panencephalitis, and Alzheimer's disease) astrocytes and oligodendrocytes were found to contain tau-positive inclusions which showed the same immunocytochemical characteristics. Thus, the widely occurring tau-positive inclusions share common phosphorylation characteristics irrespective of underlying diseases or cell types.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294505
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...