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  • Electronic Resource  (16)
  • Serotonin  (9)
  • Electron microscopy  (4)
  • Serotonin fibers  (3)
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  • Electronic Resource  (16)
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  • 1
    Electronic Resource
    Electronic Resource
    Sexual differences in the topographical distribution of serotonergic fibers in the anterior column of rat lumbar spinal cord (1984)
    Springer
    Anatomy and embryology 170 (1984), S. 117-121 
    Details
    ISSN: 1432-0568
    Keywords: Sexual dimorphism ; Serotonin fibers ; Lumbar cord ; Cremaster ; Immunohistochemistry ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sexual dimorphism in the topographical organization of immunoreactive serotonergic fibers has been shown for the first time in the anterior column of the rat lumbar cord. A characteristic preferential arrangement of serotonergic fibers on the small cell column composed of anterior horn motoneurons, which have been proved to send their axons to the cremaster muscle, was demonstrated at the lumbar segments (L1–L2) of male rats, using the immunoperoxidase technique with antiserum against serotonin. A similar finding was also observed in female rats, but was less prominent than in males. Comparative analysis of the cell numbers and the size of neuronal somata of the aforementioned nucleus, done using retrograde transport of fluorescent dye (DAPI) via axonal fibers coursing down the genitofemoral nerve to the cremaster muscle, gave significantly larger values in males. The sexual difference in the serotonergic innervation pattern was, in consequence, surmised to be caused by the cytoarchitectonic contrast ascertained in the lumbar anterior column. Furthermore, there may be a striated muscle endowed with some active functions homologous to those of the male cremaster muscle in the female rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318995
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  • 2
    Electronic Resource
    Electronic Resource
    Immunohistochemical demonstration of serotonin nerve fibers in the corpus striatum of the rat, cat and monkey (1985)
    Springer
    Anatomy and embryology 173 (1985), S. 1-5 
    Details
    ISSN: 1432-0568
    Keywords: Serotonin ; Striatum ; Globus pallidus ; Mammals (rat, cat,Macaca fuscata) ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of serotonin-containing nerve fibers in the corpus striatum of the rat, cat and monkey was studied with modified peroxidase-antiperoxidase method using serotonin antiserum without any pretreatment. In the neostriatum (caudate nucleus and putamen) of all mammalian species investigated, the immunoreactive fibers were distinct varicose fibers in a fine network. The concentration of these fibers was high in the ventral, medial and caudal neostriatum. Especially in the area bounded by the globus pallidus, serotonin fibers were abundant and compactly arranged along the nucleus. In this area of the monkey, a few thick fibers (tract fibers) were intermingled; they ran along the lateral medullary lamina. Such tract fibers were also observed outside the medial medullary lamina and in the central portion of the medial pallidal segment. The paleostriatum (globus pallidus and entopeduncular nucleus) of the rat and cat as well as the medial pallidal segment of the monkey was diffusely innervated with serotonin fibers composed of numerous varicosities and fine intervaricose segments, while in the lateral pallidal segment of the monkey, the distribution of fibers was scantly and partial. Our results hint at the morphological basis of the serotonergic regulation of the extrapyramidal system in mammals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00707298
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  • 3
    Electronic Resource
    Electronic Resource
    Light and electron microscopic immunohistochemical studies of serotonin nerve fibers in the substantia nigra of the rat, cat and monkey (1987)
    Springer
    Anatomy and embryology 176 (1987), S. 13-18 
    Details
    ISSN: 1432-0568
    Keywords: Serotonin ; Substantia nigra ; Mammals (rat, cat, Macaca fuscata) ; Immunohistochemistry ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of serotonin-containing nerve fibers in the substantia nigra of the rat, cat and monkey was studied with a highly sensitive peroxidase-antiperoxidase immunohistochemical method. Serotonin fibers in the substantia nigra of all species consisted of fine varicose fibers and formed a fine network. In the zona compacta of all species, serotonin fibers were sparsely distributed. In the zone reticularis of the rat and cat, these fibers were densely distributed and their distributional pattern was almost uniform, while in the monkey such fibers were unevenly distributed and high and low dense areas were intermingled. In the pars lateralis of all species, serotonin fibers were diffusely distributed, and the distributional density was much higher in the cat and monkey than in the rat. Immunoelectron-microscopic studies further revealed that a majority of the labeled varicosities in the rat substantia nigra were in close apposition to peridendritic axon terminals and were also free in the neuropil; occasionally they exhibited symmetrical synapses of “en passant” type with non-immunoreactive dendrites or somata. Our results support a functional significance of serotonergic regulation of the substantia nigra in mammals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309747
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  • 4
    Electronic Resource
    Electronic Resource
    Immunohistochemical demonstration of serotonin nerve fibers in the neocortex of the monkey (Macaca fuscata) (1983)
    Springer
    Anatomy and embryology 166 (1983), S. 155-168 
    Details
    ISSN: 1432-0568
    Keywords: Serotonin ; Neocortex ; Visual cortex ; Monkey ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using a peroxidase-antiperoxidase immunohistochemical method, the distribution of serotonin nerve fibers was studied in the neocortex of the monkey (Macaca fuscata). All layers of the neocortex showed evidence of serotonin fibers, both fine and thick. Unlike the distribution in rodents, different patterns of distribution were noted in each neocortex of the primate. Among the cortical areas — area 4, 3-1-2, 17, 18, 41 and 42 — the primary visual cortex (area 17) contained the highest density of immunoreactive fibers, while the primary motor cortex (area 4) possessed the lowest concentration. The most outstanding finding was a dense and laminar distribution of serotonin fibers in area 17, particularly within the upper portion of layer IVc. In area 3-1-2, 18, 41 and 42, a fairly uniform density of immunoreactive fibers was observed across the six cortical layers, apart from a relatively dense plexus of fine serotonin fibers in layer IV.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305080
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  • 5
    Electronic Resource
    Electronic Resource
    Serotonin distribution in the circumventricular organs of the rat (1983)
    Springer
    Anatomy and embryology 167 (1983), S. 311-319 
    Details
    ISSN: 1432-0568
    Keywords: Serotonin ; Circumventricular organs ; Rat ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serotonin-immunoreactive structures in the circumventricular organs (organum vasculosum laminae terminalis, subfornical organ, subcommissural organ and area postrema) of the rat were demonstrated using a modified peroxidase-antiperoxidase immunohistochemical method. Various densities of serotonin fibers were demonstrated in all four circumventricular organs; however, serotonin-positive cells were evident in the area postrema only after nialamide treatment. Serotonergic supraepedymal fibers were observed on the surface of the organum vasculosum laminae terminalis and that of the subfornical organ, but not on the subcommissural organ and area postrema. The serotonergic plexus of the basal portion of the subcommisural organ was considered to be continuous with the supraependymal plexus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315669
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  • 6
    Electronic Resource
    Electronic Resource
    Serotonergic innervation on the motoneurons in the mammalian brainstem (1983)
    Springer
    Anatomy and embryology 167 (1983), S. 321-333 
    Details
    ISSN: 1432-0568
    Keywords: Serotonin ; Immunohistochemistry ; Brainstem ; Motoneuron ; Monkey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A comparative study of serotonergic innervation on motoneurons in the brainstem of various mammals (mouse, rat, guinea pig, dog, cat and monkey) was carried out using a sensitive immunohistochemical method. Except for the extraocular muscle nuclei, the motor nuclei of the cranial nerves received rich inputs from serotonin neurons, in all species examined — rodent, carnivore and primate. The motoneurons of the monkey were innervated by varicose serotonin fibers, in a manner different from that of other species, i.e. their cell bodies and proximal dendrites were tightly encircled by a large number of serotonin-containing varicose fibers. At the ultrastructural level, a predominant population of axosomatic contacts was confirmed in the cranial motor nuclei of the monkey, particularly in the nucleus ambiguus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315670
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  • 7
    Electronic Resource
    Electronic Resource
    Electron microscopy of the arcuate nucleus of normal and 5-hydroxydopamine treated cats (1975)
    Springer
    Cell & tissue research 160 (1975), S. 139-153 
    Details
    ISSN: 1432-0878
    Keywords: Arcuate nucleus, cat ; Dense-cored vesicles ; Dopamine ; 5-Hydroxydopamine treatment ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The arcuate nucleus of normal cats and of cats treated with 5-hydroxydopamine (5-OHDA) was investigated by electron microscopy. The neurons of the arcuate nucleus were classified into three types, clear, intermediate and dark, according to their fine structure. The clear type contained numerous dense-cored vesicles and well developed cell organelles. All three types were frequently seen to be partially surrounded by glial processes. Many axo-somatic and axo-dendritic synapses mostly small in diameter were also observed around the neurons. Synaptic contacts were demonstrated between axon endings and axonal processes which contained elementary granules. After administration of 5-OHDA small and large dense-cored vesicles appeared in the nerve endings surrounding the neurons. The relationship between the dense-cored vesicles in the perikarya and dopamine was briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220574
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  • 8
    Electronic Resource
    Electronic Resource
    The zinc iodide-osmium tetroxide (ZIO) reaction on nerve endings in the median eminence of the rat under normal and experimental conditions (1976)
    Springer
    Cell & tissue research 173 (1976), S. 279-286 
    Details
    ISSN: 1432-0878
    Keywords: Median eminence ; Rat ; Monoamine ; ZIO reaction ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The reaction of nerve endings in the median eminence of the rat to zinc iodide-osmium tetroxide (ZIO) staining was examined electron microscopically under normal and experimental conditions. The experimental condition of catecholamine exhaustion in the nerve endings was induced by the administration of H44/68 and reserpine. Vesicles in the terminals of catecholaminergic nerves reacted similarly to ZIO staining in both normal and experimental material. The majority of synaptic vesicles in various terminals gave a positive ZIO reaction. The neurosecretory elementary granules, however, failed to react with ZIO. On the other hand, some nerve terminals in the external layer of the median eminence showed a strong positive reaction in the cytoplasmic matrix, in mitochondria as well as in synaptic vesicles. These findings strongly suggest that the ZIO-positive substance in nerve terminals is not the transmitter itself, i.e. the monoamine, but rather represents a range of substances commonly found in various kinds of synaptic vesicles and is probably proteinaceous in nature. A brief discussion is also given on the difference in ZIO reactivity between neurosecretory elementary granules and small vesicles in the hypothalamo-hypophyseal tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220316
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  • 9
    Electronic Resource
    Electronic Resource
    The sympathetic innervation of the ciliary body and trabecular meshwork of the cat (1976)
    Springer
    Cell & tissue research 173 (1976), S. 261-269 
    Details
    ISSN: 1432-0878
    Keywords: Cat ; Ciliary body ; ‘False’ transmitters ; Fluorescence histochemistry ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The ciliary body of the cat was investigated by fluorescence histochemistry and electron microscopy in an attempt to clarify its sympathetic innervation. Subconjunctival doses of 5-hydroxydopamine (5-OHDA) or 6-hydroxydopamine (6-OHDA) were given to establish the precise location of the sympathetic nerve terminals. The distribution of noradrenergic fibers and terminals was shown by fluorescence histochemistry to be sparse in the trabecular meshwork and the anterior portion of the ciliary muscle, but dense in the subepithelial tissue. The small and large dense core vesicles which occur in many nerve endings of the subepithelial tissue adjacent to the pigmented epithelial layer increased in electron density following the administration of 5-OHDA. Many degenerating nerve endings were found in the same region of animals treated with 6-OHDA. In contrast, there were few noradrenergic terminals in the ciliary muscle except for a portion of the smooth muscle which was shown to be dually innervated. The noradrenergic fibers in the subepithelial region and the trabecular meshwork may play an important role in aqueous secretion and outflow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221379
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  • 10
    Electronic Resource
    Electronic Resource
    Immunohistochemical study on the morphology of enterochromaffin cells in the human fundic mucosa (1984)
    Springer
    Cell & tissue research 235 (1984), S. 703-705 
    Details
    ISSN: 1432-0878
    Keywords: Enterochromaffin cells ; Serotonin ; Immunohistochemistry ; Man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The morphology of enterochromaffin (EC) cells in the human fundic mucosa was investigated at the lightmicroscopic level by means of the unlabeled peroxidase anti-peroxidase method, with the use of a highly specific anti-serotonin serum. EC-cells in the human fundic mucosa were sparsely distributed below the neck portion of the gland, but were found to be rather numerous in its lower half. Immunohistochemistry revealed marked pleomorphic and seemingly polynuclear EC-cells or cells with long, sometimes multipolar cytoplasmic processes. In addition, luminal contacts and contiguity between EC-cells, or interglandular connections were also encountered. The present immunohistochemical procedure permits, for the first time, a clear-cut morphological visualization of the entire population of EC-cells, and reveals the distinctive morphological features of these cells in the human fundic mucosa. These morphological findings imply that EC-cells in the fundic mucosa may be crucial in gastric function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226973
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