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  • Electronic Resource  (2)
  • Erythrophagocytosis  (1)
  • HIV  (1)
  • 1
    Electronic Resource
    Electronic Resource
    La rate dans la leucémie à tricholeucocytes (1977)
    Springer
    Virchows Archiv 372 (1977), S. 325-336 
    Details
    ISSN: 1432-2307
    Keywords: Ultrastructure of the spleen ; Hairy cell leukemia ; Splenic macrophages ; Erythrophagocytosis ; Splenoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fifteen spleens with hairy cell leukemia are studied with immunofluorescent (7 cases), electron microscopic (5 cases), and usual histologic methods. The findings are: enlargment of the spleen (weight always superior to 400 g), diffuse red pulp infiltration by ambiguous cells with regular repartition of nuclei and clear spaces between them, hairy aspects of the cytoplasmic membrane which are especially observed on semi-thin and ultra-thin sections, presence of particular cytoplasmic inclusion bodies (polysome lamellae complex). The cellular infiltration is accompanied by some vascular modifications: pseudo angiomatosis lesions, nodular formations ressembling splenomas. An important hypertrophy of the splenic macrophages with erythrophagocytosis and siderosis is also observed. These two phenomena partly explain the anemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432407
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    HIV-related parotid lymphoepithelial cysts (1996)
    Springer
    Virchows Archiv 429 (1996), S. 139-147 
    Details
    ISSN: 1432-2307
    Keywords: HIV ; Parotid gland ; Lymphoepithelial cyst ; Lymphoepithelial lesion ; Sjögren disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Whether lymphoepithelial cysts in the parotid glands in HIV-infected patients develop from pre-existing salivary gland inclusions in intraparotid lymph nodes or from a lymphoepithelial lesion of salivary parenchyma is unclear. To examine their pathogenesis we performed a histological and immunohistochemical study of salivary specimens from 100 AIDS patients in different disease stages. There is a continuous morphological spectrum of changes within the salivary parenchyma, starting with lymphoid stroma infiltration and evolving to characteristic lymphoepithelial duct lesions with a immunohistochemically proven basal cell proliferation and to fully developed ductal cysts. Involvement of myoepithelial cells — postulated in comparable Sjögren-associated duct lesions — is excluded immunohistochemically. Computer-assisted 3-D reconstructions confirm an association of the cysts with the intralobular duct system. Our study disproves the prevailing hypothesis, which suggests that the lymphoid cell compartment of HIV-associated lymphoepithelial cysts stems from pre-existing intraparotid lymph nodes. The results demonstrate that a secondary lymphatic infiltration of salivary parenchyma provokes a lymphoepithelial lesion of striated ducts with basal cell hyperplasia. The frequent progression to a multifocal cystic lymphoepithelial lesion may be supported by ductal compression through a high degree of lymphofollicular hyperplasia in early disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00192436
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    Paper (German National Licenses)
    Fulltext
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