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  • Electronic Resource  (2)
  • Insulin-dependent diabetes  (1)
  • Type 1 diabetes  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 18 (1980), S. 447-452 
    ISSN: 1432-0428
    Keywords: Haemoglobin A1c ; Insulin-dependent diabetes ; Blood glucose control ; Multiple insulin injections
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Haemoglobin A1c concentrations were measured in 102 insulin-treated diabetic outpatients. Only 19% had Hb A1c levels below three standard deviations above the normal mean value (5.23±0.05%). There were no correlations between Hb A1c levels, random C-peptide immunoreactivity or age. A significant correlation (r = 0.49; p〈 0.001) was, however, observed between HbA1c and random plasma glucose levels. The mean random plasma glucose value was normal (89±18 mg/ 100 ml; 5±1 mmol/l) in the patients on insulin three times a day who had received short acting insulin 160 ±6 min before the sampling. — A significant inverse correlation was found (r = -0.26; p〈0.01) between the number of daily insulin injections and the HbA1c concentration. — These results suggest that the use of multiple daily insulin injections improves diabetic control. It should however be emphasised that the patients receiving multiple insulin injections were younger than those on the single injection regime and had lower plasma insulin antibody titres, different social and psychological status and a shorter duration of the disease.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0428
    Keywords: Hypoglycaemia ; Type 1 diabetes ; diabetes management
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this study was to discover the frequency, severity and causes of hypoglycaemic reactions in Type 1 (insulin-dependent) diabetes. One hundred and seventy-two outpatients answered a questionnaire which also inquired about their feelings, opinions and fears with respect to insulin reactions. Hypoglycaemic reactions were common: a mild episode occurred at least once a month in 58% of patients, and at least one severe reaction (defined by the need of assistance) during the past year was described by 26%. Both were positively related to the duration of the disease. However, the occurrence of mild and severe attacks was not related. In addition, patients prone to mild hypoglycaemia seem to be somewhat different from patients prone to severe attacks in their attitudes towards the disease. For example, mild reactions are more frequent in patients devoted to ‘perfect’ control, whereas severe episodes were observed more frequently in those who did not think that controlling diabetes is a difficult task. The social consequences of any reaction, even mild, were important in 30% of the patients. Twenty-one percent of the patients said that the short-term risks of a hypoglycaemic reaction, even if correctly treated, were high and 6% said that the fear of having a reaction was unbearable. In addition to rational explanations, emotional factors were given as a cause of hypoglycaemia (14%), but 11% of cases felt that attacks occured without any obvious reason in spite of correct management.
    Type of Medium: Electronic Resource
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